Protein: MUS81
Structure-specific endonuclease subunit MUS81 (EC 3.1.22.-) (Crossover junction endonuclease MUS81) (MUS81 endonuclease homolog)

Gene: MUS81
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q96NY9

Gene Ontology (top 5):
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000727 - double-strand break repair via break-induced replication
GO:0003677 - DNA binding
GO:0004519 - endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1383747

EME1
Structure-specific endonuclease subunit EME1

18

3

Small-scale

0.987

High

1369958

XPF
DNA repair endonuclease XPF

3

1

High-throughput

0.855

High

464390

ERCC1
DNA excision repair protein ERCC-1

3

0

Small-scale

0.796

High

1314369

SLX4
Structure-specific endonuclease subunit SLX4

24

2

Small-scale

0.768

High

62403

EME2
Structure-specific endonuclease subunit EME2

1

4

Small-scale

0.681

High

1399305

SLX1
Structure-specific endonuclease subunit SLX1

3

0

Small-scale

0.645

High

1399311

RRP44
Exosome complex exonuclease RRP44

2

1

High-throughput

0.628

High

964420

SUMO2
Small ubiquitin-related modifier 2

2

0

Small-scale

0.577

High

355020

CHK2
Serine/threonine-protein kinase Chk2

1

4

Small-scale

0.561

High

1399303

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

1

Small-scale

0.561

High

316309

RECQ5
ATP-dependent DNA helicase Q5

1

0

Small-scale

0.537

High

1157873

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.537

High

667993

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.536

High

783645

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

814563

FEN1
Flap endonuclease 1

1

1

Small-scale

0.536

High

1151178

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

191758

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.513

High

603338

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.513

High

693914

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

859029

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

1027674

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.513

High

1053724

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

0

High-throughput

0.513

High

1125916

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

0

High-throughput

0.513

High

1316965

FAM9B
Protein FAM9B

1

0

High-throughput

0.513

High

1399302

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

997955

CSK21
Casein kinase II subunit alpha

1

1

Small-scale

0.501

High

447328

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

920207

PLK1
Serine/threonine-protein kinase PLK1

1

1

Small-scale

0.479

High

980165

H4
Histone H4

1

1

High-throughput

0.479

High

129342

MEN1
Menin

1

0

High-throughput

0.458

High

343019

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

719033

WEE1
Wee1-like protein kinase

1

0

Small-scale

0.458

High

799405

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

981024

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1045660

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1088976

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1149967

TERF2
Telomeric repeat-binding factor 2

1

0

Small-scale

0.458

High

1338568

SYNE1
Nesprin-1

1

0

High-throughput

0.458

High

1352696

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1357520

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1368571

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

1399306

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1399307

DCR1B
5' exonuclease Apollo

1

0

Small-scale

0.458

High

1399308

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1399309

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1399310

FBXL5
F-box/LRR-repeat protein 5

1

0

Small-scale

0.458

High

1399312

DCAF1
DDB1- and CUL4-associated factor 1

1

0

Small-scale

0.458

High

1399313

PIAS3
E3 SUMO-protein ligase PIAS3

1

0

Small-scale

0.458

High

1399304

SORT
Sortilin

1

1

High-throughput

0.437

High

601814

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.426

High

809792

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.426

High

391415

FRIL
Ferritin light chain

1

0

High-throughput

0.279

Low

692784

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

706269

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

967230

RRAS2
Ras-related protein R-Ras2

1

0

High-throughput

0.279

Low

1154714

VAMP3
Vesicle-associated membrane protein 3

1

0

High-throughput

0.279

Low

1219463

SLX4I
Protein SLX4IP

1

0

Small-scale

0.249

Low

211942

SPIT1
Kunitz-type protease inhibitor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025