HitPredict

Interactor 1: BIN1 (O08539)
Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Bridging integrator 1) (SH3 domain-containing protein 9)
Gene: BIN1

Interactor 2: SH3G2 (Q62420)
Endophilin-A1 (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) (SH3p4)
Gene: Sh3gl2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12456676
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BAR~BAR
Common GO terms	GO:0045202 - synapse GO:0048488 - synaptic vesicle endocytosis GO:0060988 - lipid tube assembly GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 588 Mm			1 352
+	Mm
		139038 BIN1_MOUSE (1-588): 7.74e-167: 489: 100.00		SH3G3_MOUSE (1-351): 1.51e-90: 276: 64.67
+	Mm
		139046 BIN1_MOUSE (1-588): 7.74e-167: 489: 100.00		SHLB1_MOUSE (10-347): 1.46e-72: 231: 24.79
+	Mm
		1143922 AMPH_MOUSE (9-588): 1.79e-93: 303: 35.71		SH3G2_MOUSE (1-352): 6.2e-93: 283: 100.00
+	Rn
		139969 AMPH_RAT (9-547): 1.99e-92: 300: 44.86		SH3G2_RAT (1-352): 7.14e-93: 283: 99.43
+	Mm
		1143928 AMPH_MOUSE (9-588): 1.79e-93: 303: 35.71		SH3G3_MOUSE (1-351): 1.51e-90: 276: 64.67
+	Mm
		1186721 AMPH_MOUSE (9-588): 1.79e-93: 303: 35.71		SHLB1_MOUSE (10-347): 1.46e-72: 231: 24.79
+	Hs
		131230 BIN1_HUMAN (1-587): 1.67e-155: 460: 94.60		GRB2_HUMAN (295-351): 1.18e-12: 68.2: 43.10
+	Hs
		1148372 DNMBP_HUMAN (17-584): 1.07e-76: 267: 14.14		RHG17_HUMAN (6-251): 1.62e-34: 136: 20.83
+	Hs
		827760 AMPH_HUMAN (84-588): 8.64e-21: 98.7: 18.98		SH3G2_HUMAN (1-352): 3.65e-93: 283: 98.86
+	Hs
		1052365 CABIN_HUMAN (271-535): 1.17e-24: 111: 13.76		SRC8_HUMAN (46-348): 5.2e-46: 166: 14.10
+	Hs
		1052249 ABI1_HUMAN (279-587): 1.86e-23: 105: 14.51		SRC8_HUMAN (46-348): 5.2e-46: 166: 14.10
+	Hs
		581024 ABI1_HUMAN (279-587): 1.86e-23: 105: 14.51		PLCG1_HUMAN (14-346): 7.06e-37: 143: 13.20
+	Hs
		1348439 ABI2_HUMAN (280-587): 2.27e-21: 99.8: 14.68		3BP1_HUMAN (6-260): 5.67e-39: 148: 17.83
+	Hs
		596228 ABI1_HUMAN (279-587): 1.86e-23: 105: 14.51		NEBU_HUMAN (7-347): 2.98e-36: 141: 16.99
+	Mm
		1208107 ABI1_MOUSE (279-587): 2.4e-21: 99.4: 14.84		PACN2_MOUSE (16-348): 1.22e-38: 145: 16.62
+	Hs
		1224639 ABI1_HUMAN (279-587): 1.86e-23: 105: 14.51		SRBS1_HUMAN (170-347): 6.16e-16: 81.1: 21.11
+	Hs
		924696 ABI1_HUMAN (279-587): 1.86e-23: 105: 14.51		GRB2_HUMAN (295-351): 1.18e-12: 68.2: 43.10
+	Hs
		827747 AMPH_HUMAN (84-588): 8.64e-21: 98.7: 18.98		ITSN1_HUMAN (239-346): 9.71e-13: 71.5: 20.87
+	Hs
		298987 ABI1_HUMAN (279-587): 1.86e-23: 105: 14.51		SRBS2_HUMAN (296-347): 5.15e-10: 62.8: 51.92
+	Dm
		993202 Q9VDF4_DROME (260-587): 4.99e-23: 105: 13.10		GRAP_DROME (296-344): 1.72e-10: 62: 51.02