HitPredict

Interactor 1: MKNK1 (O08605)
MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1)
Gene: MKNK1

Interactor 2: MK01 (P63085)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: Mapk1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.57 1.00 0.757

The method score is based on:

Property Details
Experiments 9155017, 15102471
Identification Methods in-gel kinase assay, two hybrid
Interaction Type phosphorylation reaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0035556 - intracellular signal transduction
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 427
Mm

1 358
+ Mm
+ Hs
+ Hs
+ Mm
+ Dm
+ Hs
+ Mm
+ Hs
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ Hs
+ Hs

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Last updated: 15 Jul 2024