HitPredict

Interactor 1: CLOCK (O08785)
Circadian locomoter output cycles protein kaput (mCLOCK) (EC 2.3.1.48)
Gene: CLOCK

Interactor 2: BMAL1 (Q9WTL8)
Basic helix-loop-helix ARNT-like protein 1 (Arnt3) (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Brain and muscle ARNT-like 1)
Gene: BMAL1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 14701732, 30683868, 16717091, 9704006, 18662546, 16606840, 24737000, 18075593, 25961797, 16777965, 21113167, 26323038, 26562092, 18662547, 28388406, 20211142, 20832105, 20840750, 23555304, 17347670 and 2 others

more...
Identification Methods affinity chromatography technology, two hybrid, bimolecular fluorescence complementation, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid array, x-ray crystallography
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH, HLH~PAS, PAS~PAS, PAS~PAS_11, PAS_11~PAS_11
Common GO terms GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
and 24 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 855
Mm

1 632
+ Hs
+ Dr
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024