Protein: VAMP4
Vesicle-associated membrane protein 4 (VAMP-4)

Gene: VAMP4
Organism: Homo sapiens
Interactions: 144
UniProt ID: O75379

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005764 - lysosome
GO:0005768 - endosome
GO:0005794 - Golgi apparatus
GO:0005802 - trans-Golgi network

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

278494

STX4
Syntaxin-4

6

20

High-throughput

0.957

High

189346

STX7
Syntaxin-7

6

20

Small-scale

0.950

High

278485

SNAA
Alpha-soluble NSF attachment protein

6

19

High-throughput

0.950

High

225882

STX6
Syntaxin-6

6

20

Small-scale

0.947

High

278526

STX12
Syntaxin-12

5

20

Small-scale

0.929

High

278580

STX8
Syntaxin-8

4

20

Small-scale

0.909

High

278542

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

4

19

Small-scale

0.903

High

278577

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

4

20

Small-scale

0.903

High

160854

STX16
Syntaxin-16

4

20

Small-scale

0.894

High

249803

STX10
Syntaxin-10

3

20

High-throughput

0.871

High

278496

STX5
Syntaxin-5

3

20

High-throughput

0.871

High

278497

STX3
Syntaxin-3

3

20

High-throughput

0.861

High

278549

SNAG
Gamma-soluble NSF attachment protein

3

19

High-throughput

0.861

High

160228

GOSR2
Golgi SNAP receptor complex member 2

2

19

High-throughput

0.811

High

278459

STX11
Syntaxin-11

2

20

High-throughput

0.811

High

278539

SCFD1
Sec1 family domain-containing protein 1

2

12

High-throughput

0.811

High

278559

SNAB
Beta-soluble NSF attachment protein

2

19

High-throughput

0.811

High

278566

VPS45
Vacuolar protein sorting-associated protein 45

2

12

High-throughput

0.811

High

278462

GOSR1
Golgi SNAP receptor complex member 1

2

5

High-throughput

0.789

High

278503

STX1A
Syntaxin-1A

2

20

High-throughput

0.783

High

278523

CPLX4
Complexin-4

2

0

High-throughput

0.742

High

278463

SNP29
Synaptosomal-associated protein 29

3

20

High-throughput

0.683

High

278538

SCFD2
Sec1 family domain-containing protein 2

2

0

High-throughput

0.679

High

278575

STX18
Syntaxin-18

3

4

High-throughput

0.667

High

278513

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

3

0

High-throughput

0.634

High

278480

NSF
Vesicle-fusing ATPase

2

6

High-throughput

0.628

High

278495

SEC20
Vesicle transport protein SEC20

2

2

High-throughput

0.628

High

278572

USE1
Vesicle transport protein USE1

2

3

High-throughput

0.628

High

278573

ANFY1
Rabankyrin-5

1

2

High-throughput

0.618

High

278510

SNP47
Synaptosomal-associated protein 47

2

3

Small-scale

0.611

High

278477

STOM
Stomatin

2

1

High-throughput

0.606

High

278504

SOAT
Sodium-dependent organic anion transporter

2

3

High-throughput

0.606

High

278532

SYT2
Synaptotagmin-2

2

4

High-throughput

0.606

High

278535

GP152
Probable G-protein coupled receptor 152

2

2

High-throughput

0.606

High

278582

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

7

High-throughput

0.606

High

278500

EPN4
Clathrin interactor 1

2

0

High-throughput

0.602

High

278509

CL12A
C-type lectin domain family 12 member A

2

0

High-throughput

0.585

High

278466

RASK
GTPase KRas

2

20

High-throughput

0.584

High

278478

EVI2B
Protein EVI2B

2

0

High-throughput

0.580

High

96843

E9PCW1
Golgi SNAP receptor complex member 1

1

5

High-throughput

0.575

High

278553

AP1M1
AP-1 complex subunit mu-1

1

3

Small-scale

0.573

High

107312

F8VWT9
HECT domain E3 ubiquitin protein ligase 4

2

3

High-throughput

0.558

High

278467

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

3

High-throughput

0.554

High

161351

PTGES
Prostaglandin E synthase

2

1

High-throughput

0.553

High

166825

MGST3
Glutathione S-transferase 3, mitochondrial

2

2

High-throughput

0.553

High

278464

NB5R3
NADH-cytochrome b5 reductase 3

2

1

High-throughput

0.553

High

278499

AQP6
Aquaporin-6

2

8

High-throughput

0.553

High

278501

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

3

High-throughput

0.553

High

278505

AR13B
ADP-ribosylation factor-like protein 13B

2

15

High-throughput

0.553

High

278508

F209A
Protein FAM209A

2

1

High-throughput

0.553

High

278524

RETR3
Reticulophagy regulator 3

2

2

High-throughput

0.553

High

278530

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

1

High-throughput

0.553

High

278536

GPX8
Probable glutathione peroxidase 8

2

2

High-throughput

0.553

High

278544

T4S19
Transmembrane 4 L6 family member 19

2

2

High-throughput

0.553

High

278546

F210B
Protein FAM210B, mitochondrial

2

2

High-throughput

0.553

High

278554

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

1

High-throughput

0.553

High

278556

ELOV4
Very long chain fatty acid elongase 4

2

6

High-throughput

0.553

High

278562

REEP4
Receptor expression-enhancing protein 4

2

1

High-throughput

0.553

High

278565

SAR1A
Small COPII coat GTPase SAR1A

2

12

High-throughput

0.553

High

278583

TMX2
Thioredoxin-related transmembrane protein 2

2

3

High-throughput

0.553

High

278472

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.541

High

60698

F234B
Protein FAM234B

1

1

High-throughput

0.536

High

123951

SNP23
Synaptosomal-associated protein 23

1

20

High-throughput

0.536

High

164886

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

2

High-throughput

0.536

High

278460

SLIK3
SLIT and NTRK-like protein 3

1

1

High-throughput

0.536

High

278520

UBE3B
Ubiquitin-protein ligase E3B

1

3

High-throughput

0.536

High

278558

F234A
Protein FAM234A

1

1

High-throughput

0.536

High

278531

KASH5
Protein KASH5

1

3

High-throughput

0.523

High

278551

B2L13
Bcl-2-like protein 13

1

1

High-throughput

0.523

High

278522

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

278534

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.513

High

278547

H6ST2
Heparan-sulfate 6-O-sulfotransferase 2

1

0

High-throughput

0.513

High

278552

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

278491

CSK21
Casein kinase II subunit alpha

1

1

Small-scale

0.501

High

278561

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.501

High

278545

VPS50
Syndetin

1

2

Small-scale

0.500

High

278484

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.489

High

278507

RABL3
Rab-like protein 3

1

16

High-throughput

0.489

High

278516

RINT1
RAD50-interacting protein 1

1

1

High-throughput

0.489

High

278470

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

1

High-throughput

0.481

High

278570

SCN3B
Sodium channel regulatory subunit beta-3

1

5

High-throughput

0.481

High

139779

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

2

High-throughput

0.479

High

217609

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

278461

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.479

High

278465

RASN
GTPase NRas

1

20

High-throughput

0.479

High

278468

CLCA
Clathrin light chain A

1

1

High-throughput

0.479

High

278469

LAMP1
Lysosome-associated membrane glycoprotein 1

1

14

High-throughput

0.479

High

278471

LAMP2
Lysosome-associated membrane glycoprotein 2

1

14

High-throughput

0.479

High

278474

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

278475

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.479

High

278476

RAB5A
Ras-related protein Rab-5A

1

20

High-throughput

0.479

High

278479

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.479

High

278482

RAB5C
Ras-related protein Rab-5C

1

20

High-throughput

0.479

High

278483

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

278486

RAB2A
Ras-related protein Rab-2A

1

20

High-throughput

0.479

High

278487

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

278488

RB11A
Ras-related protein Rab-11A

1

11

High-throughput

0.479

High

278489

AP2B1
AP-2 complex subunit beta

1

2

High-throughput

0.479

High

278493

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

278502

RAB35
Ras-related protein Rab-35

1

11

High-throughput

0.479

High

278515

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

278519

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.479

High

278528

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.479

High

278529

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

1

Small-scale

0.479

High

278541

GOGA1
Golgin subfamily A member 1

1

1

High-throughput

0.479

High

278548

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

7

High-throughput

0.479

High

278574

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

3

High-throughput

0.479

High

278581

LAMP3
Lysosome-associated membrane glycoprotein 3

1

14

High-throughput

0.479

High

278564

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.460

High

278512

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

Small-scale

0.458

High

278518

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

Small-scale

0.458

High

278579

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

1

Small-scale

0.457

High

90696

WASH3
Putative WAS protein family homolog 3

1

2

High-throughput

0.445

High

278533

SCAM5
Secretory carrier-associated membrane protein 5

1

10

Small-scale

0.445

High

278576

S53A1
Solute carrier family 53 member 1

1

5

High-throughput

0.445

High

278498

BIK
Bcl-2-interacting killer

1

1

High-throughput

0.439

High

278521

DHB13
17-beta-hydroxysteroid dehydrogenase 13

1

6

High-throughput

0.439

High

278555

TRI54
Tripartite motif-containing protein 54

1

3

High-throughput

0.439

High

278525

TMM17
Transmembrane protein 17

1

4

High-throughput

0.437

High

278563

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.437

High

278571

ELOV5
Very long chain fatty acid elongase 5

1

6

High-throughput

0.437

High

278584

HECD4
Probable E3 ubiquitin-protein ligase HECTD4

1

3

High-throughput

0.407

High

60272

NBAS
NBAS subunit of NRZ tethering complex

2

0

High-throughput

0.328

High

211697

ZW10
Centromere/kinetochore protein zw10 homolog

2

0

High-throughput

0.328

High

278473

CX6B1
Cytochrome c oxidase subunit 6B1

2

0

High-throughput

0.328

High

278550

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

2

0

High-throughput

0.328

High

71829

LEUTX
Paired-like homeodomain transcription factor LEUTX

2

0

High-throughput

0.316

High

278511

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

2

0

High-throughput

0.316

High

278514

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

2

0

High-throughput

0.316

High

278517

TM205
Transmembrane protein 205

2

0

High-throughput

0.316

High

278540

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.316

High

278557

MFF
Mitochondrial fission factor

2

0

High-throughput

0.316

High

278560

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

278567

TMM51
Transmembrane protein 51

2

0

High-throughput

0.316

High

278481

SPB8
Serpin B8

1

0

High-throughput

0.279

Low

278527

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.279

Low

278537

ZN526
Zinc finger protein 526

1

0

High-throughput

0.279

Low

278543

GALM
Galactose mutarotase

1

0

High-throughput

0.279

Low

278568

OXSM
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

1

0

High-throughput

0.279

Low

278569

CZIB
CXXC motif containing zinc binding protein

1

0

High-throughput

0.279

Low

278578

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.279

Low

278492

TOP2B
DNA topoisomerase 2-beta

1

0

High-throughput

0.269

Low

278506

GLE1
mRNA export factor GLE1

1

0

High-throughput

0.268

Low

278490

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025