Protein: VAMP2
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)

Gene: VAMP2
Organism: Homo sapiens
Interactions: 162
UniProt ID: P63027

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0005484 - SNAP receptor activity
GO:0005516 - calmodulin binding
GO:0005543 - phospholipid binding
GO:0005802 - trans-Golgi network

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

989324

STX4
Syntaxin-4

10

20

Small-scale

0.973

High

989336

STX1A
Syntaxin-1A

10

20

Small-scale

0.971

High

989325

STX3
Syntaxin-3

6

20

Small-scale

0.942

High

189501

STX7
Syntaxin-7

5

20

High-throughput

0.922

High

989352

STX12
Syntaxin-12

4

20

High-throughput

0.892

High

746190

STX2
Syntaxin-2

4

20

Small-scale

0.885

High

286642

STX11
Syntaxin-11

3

20

Small-scale

0.866

High

932991

SNAA
Alpha-soluble NSF attachment protein

3

20

Small-scale

0.866

High

989356

STX19
Syntaxin-19

3

20

High-throughput

0.861

High

989333

VAMP3
Vesicle-associated membrane protein 3

3

18

Small-scale

0.853

High

960339

STX1B
Syntaxin-1B

3

20

Small-scale

0.845

High

662337

VAMP1
Vesicle-associated membrane protein 1

3

18

High-throughput

0.827

High

225988

STX6
Syntaxin-6

2

20

High-throughput

0.789

High

954385

SNP25
Synaptosomal-associated protein 25

6

20

Small-scale

0.721

High

791270

SYUA
Alpha-synuclein

4

1

Small-scale

0.702

High

124037

SNP23
Synaptosomal-associated protein 23

4

20

Small-scale

0.698

High

989376

SNAG
Gamma-soluble NSF attachment protein

1

20

High-throughput

0.691

High

989398

STX8
Syntaxin-8

1

20

High-throughput

0.691

High

989335

SYPL1
Synaptophysin-like protein 1

3

6

High-throughput

0.675

High

989353

WDFY1
WD repeat and FYVE domain-containing protein 1

3

5

High-throughput

0.675

High

125732

STXB3
Syntaxin-binding protein 3

1

17

Small-scale

0.647

High

989378

VAMP8
Vesicle-associated membrane protein 8

1

15

Small-scale

0.647

High

343353

SNP29
Synaptosomal-associated protein 29

2

20

High-throughput

0.644

High

989363

TPC2
Two pore channel protein 2

2

2

High-throughput

0.628

High

934428

TERA
Transitional endoplasmic reticulum ATPase

3

0

Small-scale

0.620

High

989392

ANFY1
Rabankyrin-5

1

3

High-throughput

0.618

High

390531

TFR1
Transferrin receptor protein 1

2

4

High-throughput

0.611

High

989331

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

3

High-throughput

0.606

High

989340

AR13B
ADP-ribosylation factor-like protein 13B

2

17

High-throughput

0.606

High

989348

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

8

High-throughput

0.606

High

989354

ZNT8
Proton-coupled zinc antiporter SLC30A8

2

6

High-throughput

0.606

High

989357

JAGN1
Protein jagunal homolog 1

2

1

High-throughput

0.606

High

989358

TM86B
Lysoplasmalogenase TMEM86B

2

2

High-throughput

0.606

High

989364

S7A14
Solute carrier family 7 member 14

2

1

High-throughput

0.606

High

989370

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

1

High-throughput

0.606

High

989372

TM101
Transmembrane protein 101

2

1

High-throughput

0.606

High

989388

SCN3B
Sodium channel regulatory subunit beta-3

2

6

High-throughput

0.606

High

989401

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

11

High-throughput

0.606

High

507802

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

6

High-throughput

0.595

High

374513

RASH
GTPase HRas

2

20

High-throughput

0.584

High

375379

RASK
GTPase KRas

2

20

High-throughput

0.584

High

540395

LAMP1
Lysosome-associated membrane glycoprotein 1

2

17

High-throughput

0.584

High

727554

SC6A4
Sodium-dependent serotonin transporter

1

3

Small-scale

0.578

High

165140

CPLX1
Complexin-1

1

3

Small-scale

0.575

High

317409

KPCD3
Serine/threonine-protein kinase D3

1

1

Small-scale

0.573

High

529569

TAU
Microtubule-associated protein tau

2

6

High-throughput

0.571

High

845590

MUC18
Cell surface glycoprotein MUC18

2

4

High-throughput

0.571

High

728854

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

2

1

High-throughput

0.553

High

989327

AQP6
Aquaporin-6

2

9

High-throughput

0.553

High

989343

MARH8
E3 ubiquitin-protein ligase MARCHF8

2

6

High-throughput

0.553

High

989359

KASH5
Protein KASH5

2

3

High-throughput

0.553

High

989385

AT132
Polyamine-transporting ATPase 13A2

1

12

Small-scale

0.541

High

212766

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

1

High-throughput

0.536

High

302049

SEGN
Secretagogin

1

4

High-throughput

0.536

High

469474

SYPH
Synaptophysin

1

6

High-throughput

0.536

High

590269

MUC1
Mucin-1

1

2

High-throughput

0.536

High

609648

LEG3
Galectin-3

1

1

High-throughput

0.536

High

857082

NSF
Vesicle-fusing ATPase

1

9

High-throughput

0.536

High

989326

UT1
Urea transporter 1

1

1

High-throughput

0.536

High

989334

RB11B
Ras-related protein Rab-11B

1

20

High-throughput

0.536

High

989387

CENPM
Centromere protein M

1

2

High-throughput

0.536

High

989396

PRAF1
Prenylated Rab acceptor protein 1

1

1

Small-scale

0.527

High

679127

DNJB1
DnaJ homolog subfamily B member 1

1

0

High-throughput

0.513

High

989330

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

989361

T185A
Transmembrane protein 185A

1

0

High-throughput

0.513

High

989402

NTNG1
Netrin-G1

1

0

High-throughput

0.513

High

252853

EXOC3
Exocyst complex component 3

1

1

Small-scale

0.501

High

332960

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

9

Small-scale

0.501

High

856633

BAG6
Large proline-rich protein BAG6

1

3

Small-scale

0.501

High

903871

BAP31
B-cell receptor-associated protein 31

1

2

Small-scale

0.501

High

989381

DNJC5
DnaJ homolog subfamily C member 5

1

6

High-throughput

0.501

High

989390

VAPA
Vesicle-associated membrane protein-associated protein A

1

9

Small-scale

0.501

High

385634

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

High-throughput

0.481

High

989342

TMM31
Transmembrane protein 31

1

2

High-throughput

0.481

High

139840

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.479

High

165564

SCAM3
Secretory carrier-associated membrane protein 3

1

12

High-throughput

0.479

High

169500

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

10

Small-scale

0.479

High

173898

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

12

High-throughput

0.479

High

218041

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

299141

FLOT1
Flotillin-1

1

3

High-throughput

0.479

High

327217

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.479

High

341017

DIRA3
GTP-binding protein Di-Ras3

1

16

High-throughput

0.479

High

373869

RASN
GTPase NRas

1

20

High-throughput

0.479

High

463443

LYN
Tyrosine-protein kinase Lyn

1

2

High-throughput

0.479

High

466196

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

560357

IFM1
Interferon-induced transmembrane protein 1

1

7

High-throughput

0.479

High

561985

LAMP2
Lysosome-associated membrane glycoprotein 2

1

17

High-throughput

0.479

High

580979

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

603920

CXA1
Gap junction alpha-1 protein

1

8

High-throughput

0.479

High

630490

RAB3B
Ras-related protein Rab-3B

1

17

High-throughput

0.479

High

630761

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.479

High

631157

RAB5A
Ras-related protein Rab-5A

1

20

High-throughput

0.479

High

633906

ATP4A
Potassium-transporting ATPase alpha chain 1

1

13

Small-scale

0.479

High

639117

SYT1
Synaptotagmin-1

1

4

Small-scale

0.479

High

692917

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

715527

MARCS
Myristoylated alanine-rich C-kinase substrate

1

6

High-throughput

0.479

High

900764

RAB5C
Ras-related protein Rab-5C

1

20

High-throughput

0.479

High

901175

RAB7A
Ras-related protein Rab-7a

1

20

High-throughput

0.479

High

901760

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

955038

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

956242

RAB2A
Ras-related protein Rab-2A

1

20

High-throughput

0.479

High

961934

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

974971

ARF6
ADP-ribosylation factor 6

1

8

High-throughput

0.479

High

976192

RB11A
Ras-related protein Rab-11A

1

14

High-throughput

0.479

High

977918

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

988256

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

989320

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.479

High

989321

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

989322

IFM3
Interferon-induced transmembrane protein 3

1

7

High-throughput

0.479

High

989323

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

989329

RB39A
Ras-related protein Rab-39A

1

20

High-throughput

0.479

High

989332

RAB35
Ras-related protein Rab-35

1

14

High-throughput

0.479

High

989337

OCLN
Occludin

1

2

High-throughput

0.479

High

989344

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.479

High

989349

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

989350

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

989355

CXD3
Gap junction delta-3 protein

1

8

High-throughput

0.479

High

989360

DHB11
Estradiol 17-beta-dehydrogenase 11

1

8

High-throughput

0.479

High

989366

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

989367

GOGA1
Golgin subfamily A member 1

1

1

High-throughput

0.479

High

989368

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

11

High-throughput

0.479

High

989374

FMNL2
Formin-like protein 2

1

3

High-throughput

0.479

High

989375

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

989382

TMT1A
Thiol S-methyltransferase TMT1A

1

3

High-throughput

0.479

High

989386

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

989389

ELOV5
Very long chain fatty acid elongase 5

1

8

High-throughput

0.479

High

989391

TM216
Transmembrane protein 216

1

2

High-throughput

0.479

High

989393

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

4

High-throughput

0.479

High

989400

LAMP3
Lysosome-associated membrane glycoprotein 3

1

17

High-throughput

0.479

High

612965

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

873202

COPD
Coatomer subunit delta

1

0

High-throughput

0.458

High

989338

DGUOK
Deoxyguanosine kinase, mitochondrial

1

0

High-throughput

0.458

High

989365

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.458

High

223994

GET3
ATPase GET3

1

1

Small-scale

0.457

High

90703

WASH3
Putative WAS protein family homolog 3

1

2

High-throughput

0.445

High

254942

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.445

High

538835

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

4

High-throughput

0.445

High

834953

S19A1
Reduced folate transporter

1

3

High-throughput

0.445

High

989345

ZNT10
Calcium/manganese antiporter SLC30A10

1

6

High-throughput

0.445

High

989379

S19A3
Thiamine transporter 2

1

3

High-throughput

0.445

High

989384

SO1B3
Solute carrier organic anion transporter family member 1B3

1

2

High-throughput

0.445

High

989399

FLVC2
Choline/ethanolamine transporter FLVCR2

1

1

High-throughput

0.445

High

519091

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

2

High-throughput

0.437

High

989339

C19L2
CWF19-like protein 2

1

2

High-throughput

0.437

High

989346

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

989347

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

4

High-throughput

0.437

High

989351

TMM17
Transmembrane protein 17

1

5

High-throughput

0.437

High

989369

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

989371

TECT2
Tectonic-2

1

3

High-throughput

0.437

High

989380

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

3

High-throughput

0.437

High

989397

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.437

High

989328

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

989373

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

989394

RHCG
Ammonium transporter Rh type C

1

0

High-throughput

0.426

High

989362

MFSD8
Major facilitator superfamily domain-containing protein 8

1

2

High-throughput

0.407

High

989341

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

2

0

High-throughput

0.316

High

989383

CERS4
Ceramide synthase 4

2

0

High-throughput

0.316

High

989403

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

689890

FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

1

0

Small-scale

0.261

Low

606593

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

989395

NUFP1
FMR1-interacting protein NUFIP1

1

0

High-throughput

0.249

Low

989377

S35A5
UDP-sugar transporter protein SLC35A5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025