HitPredict - High confidence protein-protein interactions

Interactor 1: PCFT (Q96NT5)
Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
Gene: SLC46A1

Interactor 2: PCFT (Q96NT5)
Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
Gene: SLC46A1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	23601781
Identification Methods	cross-linking study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	MFS_1~MFS_1
Common GO terms	GO:0005542 - folic acid binding GO:0005737 - cytoplasm GO:0005768 - endosome GO:0005886 - plasma membrane GO:0006879 - intracellular iron ion homeostasis and 21 others more... GO:0008517 - folic acid transmembrane transporter activity GO:0009986 - cell surface GO:0010008 - endosome membrane GO:0015078 - proton transmembrane transporter activity GO:0015232 - heme transmembrane transporter activity GO:0015293 - symporter activity GO:0015350 - methotrexate transmembrane transporter activity GO:0015884 - folic acid transport GO:0016323 - basolateral plasma membrane GO:0016324 - apical plasma membrane GO:0022857 - transmembrane transporter activity GO:0031526 - brush border membrane GO:0042168 - heme metabolic process GO:0046654 - tetrahydrofolate biosynthetic process GO:0046655 - folic acid metabolic process GO:0055085 - transmembrane transport GO:0098829 - intestinal folate absorption GO:0098838 - folate transmembrane transport GO:0140211 - folic acid:proton symporter activity GO:1902600 - proton transmembrane transport GO:1904447 - folate import across plasma membrane
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	459
Hs

1	459

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Last updated: 11Aug2025