Protein: MFSD8
Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7)

Gene: MFSD8
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q8NHS3

Gene Ontology (top 5):
GO:0005254 - chloride channel activity
GO:0005739 - mitochondrion
GO:0005765 - lysosomal membrane
GO:0006096 - glycolytic process
GO:0006664 - glycolipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1291751

S22AG
Solute carrier family 22 member 16

2

11

High-throughput

0.726

High

1308903

S22A9
Organic anion transporter 7

2

11

High-throughput

0.726

High

1340563

S22A4
Solute carrier family 22 member 4

1

6

High-throughput

0.691

High

1340579

NB5R1
NADH-cytochrome b5 reductase 1

3

2

High-throughput

0.662

High

380460

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

3

8

High-throughput

0.656

High

669035

FPR2
N-formyl peptide receptor 2

2

11

High-throughput

0.628

High

1053033

VMAT2
Synaptic vesicular amine transporter

1

9

High-throughput

0.618

High

455991

ASGR2
Asialoglycoprotein receptor 2

3

3

High-throughput

0.609

High

1192263

ZACN
Ligand-gated cation channel ZACN

3

2

High-throughput

0.609

High

1340546

LPAR1
Lysophosphatidic acid receptor 1

3

6

High-throughput

0.609

High

1340565

P2Y12
P2Y purinoceptor 12

3

10

High-throughput

0.609

High

1340549

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

2

0

High-throughput

0.576

High

749364

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

1

High-throughput

0.574

High

845525

PI2R
Prostacyclin receptor

2

3

High-throughput

0.574

High

878061

AGRE5
Adhesion G protein-coupled receptor E5

2

4

High-throughput

0.574

High

1159085

C3AR
C3a anaphylatoxin chemotactic receptor

2

8

High-throughput

0.574

High

1164055

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

2

6

High-throughput

0.574

High

1316329

AGRG5
Adhesion G-protein coupled receptor G5

2

4

High-throughput

0.574

High

1340555

GPR21
Probable G-protein coupled receptor 21

2

4

High-throughput

0.574

High

1233369

LTOR1
Ragulator complex protein LAMTOR1

2

1

High-throughput

0.571

High

1053817

KDSR
3-ketodihydrosphingosine reductase

2

4

High-throughput

0.549

High

905759

CAV2
Caveolin-2

1

2

High-throughput

0.536

High

1340544

SPP2B
Signal peptide peptidase-like 2B

1

1

High-throughput

0.536

High

901956

RAB9A
Ras-related protein Rab-9A

2

5

High-throughput

0.521

High

820695

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.517

High

333499

MPZL1
Myelin protein zero-like protein 1

1

2

High-throughput

0.514

High

1333864

MFSD9
Major facilitator superfamily domain-containing protein 9

1

18

High-throughput

0.514

High

599215

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.513

High

322044

ENDD1
Endonuclease domain-containing 1 protein

1

1

High-throughput

0.489

High

326440

S1PR2
Sphingosine 1-phosphate receptor 2

1

6

High-throughput

0.489

High

349495

TSN15
Tetraspanin-15

1

3

High-throughput

0.489

High

622081

CD53
Leukocyte surface antigen CD53

1

3

High-throughput

0.489

High

640423

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

11

High-throughput

0.489

High

702811

5HT2C
5-hydroxytryptamine receptor 2C

1

3

High-throughput

0.489

High

711576

NK3R
Neuromedin-K receptor

1

4

High-throughput

0.489

High

719816

V2R
Vasopressin V2 receptor

1

6

High-throughput

0.489

High

722545

CTR1
High affinity cationic amino acid transporter 1

1

5

High-throughput

0.489

High

832432

OPRX
Nociceptin receptor

1

9

High-throughput

0.489

High

907036

CCR6
C-C chemokine receptor type 6

1

5

High-throughput

0.489

High

956946

CXCR4
C-X-C chemokine receptor type 4

1

7

High-throughput

0.489

High

1101596

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

9

High-throughput

0.489

High

1126243

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

1

High-throughput

0.489

High

1340550

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

1

High-throughput

0.489

High

1340577

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

High-throughput

0.489

High

1340581

FZD10
Frizzled-10

1

2

High-throughput

0.489

High

562247

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

956408

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.479

High

1340583

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

97111

E9PMV2
Major histocompatibility complex, class II, DQ alpha 1

1

8

High-throughput

0.445

High

189723

STX7
Syntaxin-7

1

6

High-throughput

0.445

High

420823

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

1

High-throughput

0.445

High

445978

ENOA
Alpha-enolase

1

1

High-throughput

0.445

High

447812

TPM3
Tropomyosin alpha-3 chain

1

2

High-throughput

0.445

High

463664

LYN
Tyrosine-protein kinase Lyn

1

2

High-throughput

0.445

High

604112

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.445

High

690311

STOM
Stomatin

1

2

High-throughput

0.445

High

773230

MYH10
Myosin-10

1

1

High-throughput

0.445

High

774509

BASI
Basigin

1

1

High-throughput

0.445

High

931411

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

1

High-throughput

0.445

High

989856

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

6

High-throughput

0.445

High

1147387

EPHA7
Ephrin type-A receptor 7

1

8

High-throughput

0.445

High

1205002

RABL3
Rab-like protein 3

1

4

High-throughput

0.445

High

1278039

MAVS
Mitochondrial antiviral-signaling protein

1

1

High-throughput

0.445

High

1308167

PLD3
5'-3' exonuclease PLD3

1

3

High-throughput

0.445

High

1333101

AT11C
Phospholipid-transporting ATPase IG

1

3

High-throughput

0.445

High

1340547

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

2

High-throughput

0.445

High

1340554

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

High-throughput

0.445

High

1340556

ABCA3
Phospholipid-transporting ATPase ABCA3

1

1

High-throughput

0.445

High

1340558

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

2

High-throughput

0.445

High

1340559

VAMP8
Vesicle-associated membrane protein 8

1

4

High-throughput

0.445

High

1340560

TMM59
Transmembrane protein 59

1

2

High-throughput

0.445

High

1340568

ABCB6
ATP-binding cassette sub-family B member 6

1

2

High-throughput

0.445

High

1340570

ITM2C
Integral membrane protein 2C

1

7

High-throughput

0.445

High

1340580

COR1C
Coronin-1C

1

1

High-throughput

0.445

High

1340582

MYO6
Unconventional myosin-VI

1

4

High-throughput

0.445

High

1340586

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

2

High-throughput

0.445

High

403204

APOB
Apolipoprotein B-100

1

0

High-throughput

0.426

High

536273

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.426

High

553244

KCRB
Creatine kinase B-type

1

0

High-throughput

0.426

High

800537

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.426

High

828228

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.426

High

1228762

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

High-throughput

0.426

High

1241096

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

0

High-throughput

0.426

High

1340557

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.426

High

1340564

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.426

High

1340572

T106B
Transmembrane protein 106B

1

0

High-throughput

0.426

High

1340584

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

High-throughput

0.426

High

125768

STXB3
Syntaxin-binding protein 3

1

2

High-throughput

0.407

High

130178

PGRC1
Membrane-associated progesterone receptor component 1

1

6

High-throughput

0.407

High

193712

TPSN
Tapasin

1

5

High-throughput

0.407

High

212453

SPIT2
Kunitz-type protease inhibitor 2

1

10

High-throughput

0.407

High

231507

ORC4
Origin recognition complex subunit 4

1

1

High-throughput

0.407

High

316534

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

1

High-throughput

0.407

High

331900

GOSR1
Golgi SNAP receptor complex member 1

1

1

High-throughput

0.407

High

409457

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.407

High

418708

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

6

High-throughput

0.407

High

463167

YES
Tyrosine-protein kinase Yes

1

2

High-throughput

0.407

High

467281

MDR1
ATP-dependent translocase ABCB1

1

1

High-throughput

0.407

High

482932

TPM1
Tropomyosin alpha-1 chain

1

2

High-throughput

0.407

High

609753

LEG3
Galectin-3

1

2

High-throughput

0.407

High

693412

CERS1
Ceramide synthase 1

1

3

High-throughput

0.407

High

867285

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.407

High

962290

RHOA
Transforming protein RhoA

1

7

High-throughput

0.407

High

986582

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.407

High

989362

VAMP2
Vesicle-associated membrane protein 2

1

2

High-throughput

0.407

High

1041185

CAV1
Caveolin-1

1

2

High-throughput

0.407

High

1087200

STX4
Syntaxin-4

1

6

High-throughput

0.407

High

1089983

LMAN2
Vesicular integral-membrane protein VIP36

1

3

High-throughput

0.407

High

1120771

DSG2
Desmoglein-2

1

3

High-throughput

0.407

High

1150599

TRAM1
Translocating chain-associated membrane protein 1

1

3

High-throughput

0.407

High

1154060

MSMO1
Methylsterol monooxygenase 1

1

3

High-throughput

0.407

High

1154683

VAMP3
Vesicle-associated membrane protein 3

1

2

High-throughput

0.407

High

1158777

SYPL1
Synaptophysin-like protein 1

1

1

High-throughput

0.407

High

1160692

DREB
Drebrin

1

2

High-throughput

0.407

High

1218790

BROX
BRO1 domain-containing protein BROX

1

1

High-throughput

0.407

High

1219238

SYPL2
Synaptophysin-like protein 2

1

1

High-throughput

0.407

High

1250739

MPRIP
Myosin phosphatase Rho-interacting protein

1

3

High-throughput

0.407

High

1270380

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.407

High

1278292

LRP10
Low-density lipoprotein receptor-related protein 10

1

3

High-throughput

0.407

High

1313622

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

1

1

High-throughput

0.407

High

1315816

AN13A
Ankyrin repeat domain-containing protein 13A

1

3

High-throughput

0.407

High

1334470

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.407

High

1340543

GOGA5
Golgin subfamily A member 5

1

3

High-throughput

0.407

High

1340545

PDC6I
Programmed cell death 6-interacting protein

1

3

High-throughput

0.407

High

1340548

PKHB2
Pleckstrin homology domain-containing family B member 2

1

2

High-throughput

0.407

High

1340551

CERS2
Ceramide synthase 2

1

3

High-throughput

0.407

High

1340553

CREL1
Protein disulfide isomerase CRELD1

1

6

High-throughput

0.407

High

1340567

SEC12
Guanine nucleotide-exchange factor SEC12

1

1

High-throughput

0.407

High

1340569

CD320
CD320 antigen

1

2

High-throughput

0.407

High

1340571

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.407

High

1340573

CC50A
Cell cycle control protein 50A

1

1

High-throughput

0.407

High

1340576

CNIH4
Protein cornichon homolog 4

1

3

High-throughput

0.407

High

1340578

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.407

High

1340585

RAP2C
Ras-related protein Rap-2c

1

3

High-throughput

0.407

High

1340587

RN114
E3 ubiquitin-protein ligase RNF114

1

3

High-throughput

0.407

High

450258

HYEP
Epoxide hydrolase 1

3

0

High-throughput

0.345

High

1292012

TPRA1
Transmembrane protein adipocyte-associated 1

2

0

High-throughput

0.328

High

1340561

YIPF3
Protein YIPF3

2

0

High-throughput

0.328

High

1340566

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.328

High

1331176

F241A
Uncharacterized protein FAM241A

2

0

High-throughput

0.313

High

230712

NKG2F
NKG2-F type II integral membrane protein

1

0

High-throughput

0.279

Low

1055131

CCG1
Voltage-dependent calcium channel gamma-1 subunit

1

0

High-throughput

0.279

Low

1142891

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.279

Low

1200364

KCP3
Keratinocyte-associated protein 3

1

0

High-throughput

0.279

Low

1333411

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.279

Low

1340552

BSCL2
Seipin

1

0

High-throughput

0.279

Low

1340562

GPR88
G protein-coupled receptor 88

1

0

High-throughput

0.279

Low

219336

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.232

Low

226442

SNG2
Synaptogyrin-2

1

0

High-throughput

0.232

Low

341447

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.232

Low

420628

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.232

Low

577827

PLAK
Junction plakoglobin

1

0

High-throughput

0.232

Low

616209

PGAM1
Phosphoglycerate mutase 1

1

0

High-throughput

0.232

Low

618200

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

0

High-throughput

0.232

Low

906325

GPC3
Glypican-3

1

0

High-throughput

0.232

Low

1329502

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

0

High-throughput

0.232

Low

1340574

T161A
Transmembrane protein 161A

1

0

High-throughput

0.232

Low

1340575

TMOD3
Tropomodulin-3

1

0

High-throughput

0.232

Low

1340588

BACE2
Beta-secretase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025