HitPredict

Interactor 1: DHB14 (Q9BPX1)
L-fucose dehydrogenase (EC 1.1.1.122) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1)
Gene: HSD17B14

Interactor 2: DHB14 (Q9BPX1)
L-fucose dehydrogenase (EC 1.1.1.122) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1)
Gene: HSD17B14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.952

Property	Details
Experiments	25416956, 16189514, 27107012, 32296183, 31515488, unassigned1304
Identification Methods	two hybrid, two hybrid array, barcode fusion genetics two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	adh_short_C2~adh_short_C2
Common GO terms	GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0005829 - cytosol GO:0006706 - steroid catabolic process GO:0042355 - L-fucose catabolic process GO:0047834 - D-threo-aldose 1-dehydrogenase activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 270 Hs			1 270
+	Hs
		1413839 DHRS4_HUMAN (1-249): 5.28e-88: 264: 26.67		DHRS4_HUMAN (1-249): 5.28e-88: 264: 26.67
+	Dm
		1343559 Q8SX57_DROME (4-255): 1.03e-87: 263: 33.33		Q8SX57_DROME (4-255): 1.03e-87: 263: 33.33
+	Dm
		1304688 Q8SX57_DROME (4-255): 1.03e-87: 263: 33.33		Q8IPP8_DROME (5-255): 1.74e-85: 257: 32.69
+	Dm
		1343561 Q8SX57_DROME (4-255): 1.03e-87: 263: 33.33		Q9VNF3_DROME (4-255): 1.3e-85: 257: 32.95
+	Dm
		1304689 Q8IPP8_DROME (5-255): 1.74e-85: 257: 32.69		Q9VNF3_DROME (4-255): 1.3e-85: 257: 32.95
+	Hs
		1409639 DHRS4_HUMAN (1-249): 5.28e-88: 264: 26.67		DHB14_HUMAN (18-270): 4.23e-81: 246: 100.00
+	Ce
		1445092 Q9N5G3_CAEEL (4-259): 2.77e-82: 250: 29.41		Q9N5G3_CAEEL (4-259): 2.77e-82: 250: 29.41
+	Ss
		1355736 DHRS4_PIG (3-249): 2.34e-81: 247: 26.88		DHRS4_PIG (3-249): 2.34e-81: 247: 26.88
+	Mm
		1408815 DHRS4_MOUSE (1-249): 2.95e-80: 245: 25.88		DHRS4_MOUSE (1-249): 2.95e-80: 245: 25.88
+	At
		1441465 TRNHF_ARATH (2-252): 4.4e-82: 248: 29.07		SAG13_ARATH (2-252): 1.71e-79: 242: 28.68
+	At
		1441466 TRNHF_ARATH (2-252): 4.4e-82: 248: 29.07		TRNHC_ARATH (4-257): 9.88e-79: 240: 28.63
+	Ce
		234203 Q19774_CAEEL (4-259): 3.4e-80: 244: 25.56		O45709_CAEEL (4-259): 1.47e-78: 240: 24.82
+	At
		1441464 TRNHF_ARATH (2-252): 4.4e-82: 248: 29.07		TRNHA_ARATH (1-257): 7.89e-75: 230: 28.68
+	At
		1342066 SAG13_ARATH (2-252): 1.71e-79: 242: 28.68		TRNH2_ARATH (3-257): 6.16e-74: 228: 28.90
+	Hs
		1413842 DHRS4_HUMAN (1-249): 5.28e-88: 264: 26.67		DHRS6_HUMAN (6-251): 2.58e-25: 102: 32.27