Protein: DHRS6
Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1)

Gene: DHRS6, BDH2
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q9BUT1

Gene Ontology (top 5):
GO:0003858 - 3-hydroxybutyrate dehydrogenase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006635 - fatty acid beta-oxidation
GO:0016617 - 4-oxoproline reductase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1414697

DHRS6
Dehydrogenase/reductase SDR family member 6

2

16

High-throughput

0.785

High

1413842

DHRS4
Dehydrogenase/reductase SDR family member 4

1

16

High-throughput

0.691

High

1414703

WWOX
WW domain-containing oxidoreductase

1

16

High-throughput

0.691

High

564318

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.541

High

791679

SYUA
Alpha-synuclein

2

0

Small-scale

0.539

High

1022784

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

High-throughput

0.536

High

1363538

TRIB2
Tribbles homolog 2

1

1

High-throughput

0.536

High

126004

RB27B
Ras-related protein Rab-27B

1

0

High-throughput

0.513

High

377042

NEU2
Vasopressin-neurophysin 2-copeptin

1

0

High-throughput

0.513

High

1099768

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1122767

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.513

High

1241181

MET2B
tRNA N(3)-cytidine methyltransferase METTL2B

1

0

High-throughput

0.513

High

1270409

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.513

High

1279123

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.513

High

1405090

VAT1
Synaptic vesicle membrane protein VAT-1 homolog

1

0

High-throughput

0.513

High

1405411

T22D3
TSC22 domain family protein 3

1

0

High-throughput

0.513

High

1408434

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.513

High

1414699

CYREN
Cell cycle regulator of non-homologous end joining

1

0

High-throughput

0.513

High

1414700

CDCA4
Cell division cycle-associated protein 4

1

0

High-throughput

0.513

High

1414704

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

0

High-throughput

0.513

High

1414706

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

0

High-throughput

0.513

High

1327379

ZCHC9
Zinc finger CCHC domain-containing protein 9

1

1

High-throughput

0.489

High

537818

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

1255332

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

515731

TPC2B
Trafficking protein particle complex subunit 2B

1

0

High-throughput

0.458

High

1164318

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

1

0

Small-scale

0.458

High

589573

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

696383

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769052

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1119606

NFYC
Nuclear transcription factor Y subunit gamma

2

0

High-throughput

0.316

High

709050

NEC1
Neuroendocrine convertase 1

1

0

High-throughput

0.279

Low

753929

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

0

High-throughput

0.279

Low

1023973

EM55
55 kDa erythrocyte membrane protein

1

0

High-throughput

0.279

Low

1150946

TRIPB
Thyroid receptor-interacting protein 11

1

0

High-throughput

0.279

Low

1325483

FNBP4
Formin-binding protein 4

1

0

High-throughput

0.279

Low

1391368

CFA36
Cilia- and flagella-associated protein 36

1

0

High-throughput

0.279

Low

1414698

DCC1
Sister chromatid cohesion protein DCC1

1

0

High-throughput

0.279

Low

1414701

TX13A
Testis-expressed protein 13A

1

0

High-throughput

0.279

Low

1414702

TMOD3
Tropomodulin-3

1

0

High-throughput

0.279

Low

1414705

EID1
EP300-interacting inhibitor of differentiation 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025