HitPredict - High confidence protein-protein interactions

Interactor 1: DERL1 (Q9BUN8)
Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)
Gene: DERL1

Interactor 2: DERL1 (Q9BUN8)
Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)
Gene: DERL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17453418
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DER1~DER1
Common GO terms	GO:0002020 - protease binding GO:0005047 - signal recognition particle binding GO:0005769 - early endosome GO:0005770 - late endosome GO:0005783 - endoplasmic reticulum and 20 others more... GO:0005789 - endoplasmic reticulum membrane GO:0006986 - response to unfolded protein GO:0016020 - membrane GO:0030968 - endoplasmic reticulum unfolded protein response GO:0030970 - retrograde protein transport, ER to cytosol GO:0031398 - positive regulation of protein ubiquitination GO:0031625 - ubiquitin protein ligase binding GO:0031648 - protein destabilization GO:0036502 - Derlin-1-VIMP complex GO:0036503 - ERAD pathway GO:0036513 - Derlin-1 retrotranslocation complex GO:0038023 - signaling receptor activity GO:0042288 - MHC class I protein binding GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0044322 - endoplasmic reticulum quality control compartment GO:0044877 - protein-containing complex binding GO:0045184 - establishment of protein localization GO:0051117 - ATPase binding GO:0071218 - cellular response to misfolded protein GO:1990381 - ubiquitin-specific protease binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1	251
Hs

1	251

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Last updated: 11Aug2025