HitPredict

Interactor 1: PRP19 (O14011)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Complexed with cdc5 protein 8) (RING-type E3 ubiquitin transferase PRP19)
Gene: PRP19

Interactor 2: CWC2 (P87126)
Pre-mRNA-splicing factor cwf2 (Complexed with cdc5 protein 2) (Pre-mRNA-processing protein 3)
Gene: cwf2

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.626

Property	Details
Experiments	12088152, 21386897
Identification Methods	two hybrid, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000974 - Prp19 complex GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0071006 - U2-type catalytic step 1 spliceosome GO:0071014 - post-mRNA release spliceosomal complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 488 Sp			1 388
+	Hs
		1347097 PRP19_HUMAN (1-487): 1.28e-115: 351: 25.69		RBM22_HUMAN (84-275): 9.1e-72: 232: 22.82
+	Sc
		692372 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		CWC2_YEAST (46-295): 4.28e-58: 194: 36.86
+	Hs
		1288340 SNR40_HUMAN (148-398): 1.71e-49: 175: 9.24		RBM22_HUMAN (84-275): 9.1e-72: 232: 22.82
+	Sc
		692337 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		NAM8_YEAST (33-248): 7.51e-24: 104: 12.22
+	Hs
		903196 WDR5_HUMAN (130-360): 3.43e-35: 135: 8.47		PABP4_HUMAN (2-292): 2.87e-49: 177: 14.62
+	Hs
		516438 WDR5_HUMAN (130-360): 3.43e-35: 135: 8.47		PABP1_HUMAN (2-307): 5.91e-49: 176: 12.93