HitPredict

Interactor 1: MYO3 (O14157)
Myosin type-2 heavy chain 2 (Myosin type II heavy chain 2)
Gene: MYO3

Interactor 2: MLR4 (Q09196)
Myosin regulatory light chain cdc4
Gene: cdc4

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.800

Property	Details
Experiments	10769212, 11069761
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head, EF-hand_7~Myosin_N
Common GO terms	GO:0005737 - cytoplasm GO:0016460 - myosin II complex GO:0032153 - cell division site GO:0110085 - mitotic actomyosin contractile ring GO:1903475 - mitotic actomyosin contractile ring assembly
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2104 Sp			1 141
+	Dm
		906697 MYO7A_DROME (35-961): 0: 951: 30.62		CALM_DROME (2-140): 2.2e-47: 151: 38.19
+	Dm
		870146 MYO7A_DROME (35-961): 0: 951: 30.62		MLC2_DROME (2-140): 7.73e-45: 145: 34.75
+	Sp
		998275 MYO2_SCHPO (15-1198): 0: 862: 44.04		MLR4_SCHPO (1-141): 2.34e-44: 143: 100.00
+	Hs
		538680 MYH14_HUMAN (37-1069): 0: 628: 39.74		MYL6B_HUMAN (3-140): 2.39e-42: 140: 38.89
+	Hs
		891551 MYH14_HUMAN (37-1069): 0: 628: 39.74		MYL6_HUMAN (2-140): 5.07e-43: 140: 37.24
+	Sc
		446196 MYO1_YEAST (40-1164): 0: 619: 38.21		MLC1_YEAST (9-139): 6.57e-28: 102: 43.57
+	Ce
		104561 G5EBY3_CAEEL (9-1920): 0: 607: 28.48		CALM_CAEEL (73-140): 1.66e-12: 62.5: 28.99
+	Hs
		538643 MYH10_HUMAN (1099-2101): 5.38e-40: 166: 13.88		MYL6B_HUMAN (3-140): 2.39e-42: 140: 38.89
+	Hs
		725124 MYH10_HUMAN (1099-2101): 5.38e-40: 166: 13.88		MYL6_HUMAN (2-140): 5.07e-43: 140: 37.24
+	Hs
		648467 MYH9_HUMAN (1134-2099): 2.19e-36: 154: 13.01		CALL3_HUMAN (2-140): 3.03e-45: 146: 38.19
+	Dm
		870145 MYSN_DROME (1217-2088): 3.73e-36: 153: 14.42		MLC2_DROME (2-140): 7.73e-45: 145: 34.75
+	Hs
		538642 MYH9_HUMAN (1134-2099): 2.19e-36: 154: 13.01		MYL6B_HUMAN (3-140): 2.39e-42: 140: 38.89
+	Hs
		724737 MYH9_HUMAN (1134-2099): 2.19e-36: 154: 13.01		MYL6_HUMAN (2-140): 5.07e-43: 140: 37.24
+	Hs
		409452 MYH10_HUMAN (1099-2101): 5.38e-40: 166: 13.88		MYL1_HUMAN (8-140): 1.9e-25: 97.1: 38.13
+	Hs
		728458 MYH11_HUMAN (847-1534): 8.22e-26: 119: 13.41		MYL6_HUMAN (2-140): 5.07e-43: 140: 37.24
+	Gg
		361265 MYH11_CHICK (830-1327): 5.53e-23: 109: 13.22		MYL6_CHICK (2-140): 4.86e-43: 140: 35.86
+	Hs
		484218 MYO5B_HUMAN (1297-1975): 4.32e-17: 90.6: 8.78		CALM3_HUMAN (2-140): 7.28e-48: 152: 39.58