HitPredict

Interactor 1: TOR1 (O14356)
Serine/threonine-protein kinase tor1 (EC 2.7.11.1) (Phosphatidylinositol kinase homolog tor1) (Target of rapamycin kinase 1)
Gene: TOR1

Interactor 2: SIN1 (Q9P7Y9)
Target of rapamycin complex 2 subunit sin1 (TORC2 subunit sin1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1)
Gene: SIN1

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	28264193, 27206859, 25590601, 18076573, 17261596, 22645648
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CRIM~FRB_dom, CRIM~PI3_PI4_kinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle GO:0031932 - TORC2 complex GO:0038203 - TORC2 signaling and 1 others more... GO:0051321 - meiotic cell cycle
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 2335 Sp			1 665
+	Sp
		1350879 TOR2_SCHPO (1-2335): 0: 1803: 51.84		SIN1_SCHPO (1-665): 0: 956: 100.00
+	Hs
		787554 MTOR_HUMAN (2-2335): 0: 1603: 39.63		SIN1_HUMAN (163-660): 1.19e-123: 378: 21.86
+	Mm
		1206836 MTOR_MOUSE (2-2335): 0: 1596: 39.39		SIN1_MOUSE (163-660): 2.88e-121: 372: 21.29
+	Sc
		696538 TOR2_YEAST (4-2335): 0: 1719: 44.44		AVO1_YEAST (523-662): 2.93e-39: 157: 32.87
+	Dm
		1360205 TOR_DROME (2-2335): 0: 1596: 38.57		SIN1_DROME (192-385): 1.14e-64: 225: 19.51
+	Hs
		944396 PRKDC_HUMAN (4-2334): 0: 762: 14.96		SIN1_HUMAN (163-660): 1.19e-123: 378: 21.86