Protein: PROF
Profilin (Protein chickadee)

Gene: PROF, chic
Organism: Drosophila melanogaster
Interactions: 200
UniProt ID: P25843

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0000902 - cell morphogenesis
GO:0000915 - actomyosin contractile ring assembly
GO:0003785 - actin monomer binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

682769

ENA
Protein enabled

3

11

Small-scale

0.670

High

682708

ARP3
Actin-related protein 3

1

17

High-throughput

0.656

High

682828

Q9VPX6
Adenylyl cyclase-associated protein

3

2

Small-scale

0.633

High

578036

ENO
Enolase

2

1

High-throughput

0.571

High

649003

ANX10
Annexin B10

2

2

High-throughput

0.571

High

682709

UCHL
Ubiquitin carboxyl-terminal hydrolase

2

2

High-throughput

0.571

High

682714

MOEH
Moesin/ezrin/radixin homolog 1

2

2

High-throughput

0.571

High

682719

PDI
Protein disulfide-isomerase

2

3

High-throughput

0.571

High

682738

NLP
Nucleoplasmin-like protein

2

2

High-throughput

0.571

High

682781

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

2

1

High-throughput

0.571

High

682827

Q9VPN5
Stress-induced-phosphoprotein 1

2

2

High-throughput

0.571

High

195001

O16043
Anon1A4

2

0

High-throughput

0.547

High

357465

INO1
Inositol-3-phosphate synthase

2

0

High-throughput

0.547

High

682764

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

2

0

High-throughput

0.547

High

682770

NACA
Nascent polypeptide-associated complex subunit alpha

2

0

High-throughput

0.547

High

682778

IF5A
Eukaryotic translation initiation factor 5A

2

0

High-throughput

0.547

High

682804

TCTP
Translationally-controlled tumor protein homolog

2

0

High-throughput

0.547

High

682733

CAPU
Protein cappuccino

2

18

Small-scale

0.545

High

682741

Q7JQL5
Autophagy-related protein 9

1

0

Small-scale

0.529

High

356298

O97102
Small ubiquitin-related modifier

2

2

High-throughput

0.521

High

682706

CALR
Calreticulin

2

1

High-throughput

0.521

High

682726

PGK
Phosphoglycerate kinase

2

1

High-throughput

0.521

High

682745

Q7JX87
1-Cys peroxiredoxin

2

3

High-throughput

0.521

High

682783

Q9V3V2
peptidylprolyl isomerase

2

3

High-throughput

0.521

High

682802

Q9VGK3
peptidylprolyl isomerase

2

4

High-throughput

0.521

High

682837

Q9VTY2
Uncharacterized protein, isoform A

2

4

High-throughput

0.521

High

682838

Q9VU35
10 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.521

High

682712

RAC1
Ras-related protein Rac1

1

4

Small-scale

0.515

High

682794

Q9VAT0
RE12101p

1

5

High-throughput

0.508

High

682722

ACT6
Actin, indirect flight muscle

1

18

High-throughput

0.492

High

120746

M9PE30
Transgelin

1

3

High-throughput

0.479

High

682717

DIA
Protein diaphanous

1

20

Small-scale

0.479

High

682735

DIAP1
Death-associated inhibitor of apoptosis 1

1

3

Small-scale

0.479

High

682761

Q8IRS7
Ciboulot, isoform C

1

1

High-throughput

0.479

High

682762

Q8IRY0
Dishevelled associated activator of morphogenesis, isoform B

1

20

Small-scale

0.479

High

57521

A1ZB71
Glutathione S transferase E6

1

1

High-throughput

0.445

High

234540

VINC
Vinculin

1

1

High-throughput

0.445

High

357254

O97428
Ciboulot, isoform A

1

1

High-throughput

0.445

High

556637

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.445

High

561763

MODU
DNA-binding protein modulo

1

1

High-throughput

0.445

High

611463

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.445

High

648856

ANXB9
Annexin B9

1

2

High-throughput

0.445

High

682707

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

682715

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

1

4

High-throughput

0.445

High

682721

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.445

High

682724

TRXR1
Thioredoxin reductase 1, mitochondrial

1

3

High-throughput

0.445

High

682730

GRAP
Growth factor receptor-bound protein 2

1

2

High-throughput

0.445

High

682752

TERA
Transitional endoplasmic reticulum ATPase TER94

1

3

High-throughput

0.445

High

682758

Q8IQZ7
FI19014p1

1

2

High-throughput

0.445

High

682765

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.445

High

682788

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

3

High-throughput

0.445

High

682792

Q9VAC4
GEO09167p1

1

2

High-throughput

0.445

High

682799

Q9VEB1
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

682813

Q9VJ30
non-specific serine/threonine protein kinase

1

8

High-throughput

0.445

High

682815

Q9VKB0
threonine--tRNA ligase

1

1

High-throughput

0.445

High

682820

FKB59
FK506-binding protein 59

1

2

High-throughput

0.445

High

682822

AK200
A-kinase anchor protein 200

1

6

High-throughput

0.445

High

682823

SYAC
Alanine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.445

High

682824

Q9VLS7
LD21067p

1

3

High-throughput

0.445

High

682825

Q9VMH3
LD04103p

1

2

High-throughput

0.445

High

682831

Q9VQL1
serine--tRNA ligase

1

2

High-throughput

0.445

High

682832

Q9VRD6
NTF2-related export protein

1

1

High-throughput

0.445

High

682836

Q9VSL2
Glutathione S transferase O3

1

1

High-throughput

0.445

High

682840

Q9VUC1
Hsc70Cb, isoform A

1

4

High-throughput

0.445

High

682851

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.445

High

682852

Q9VZI1
Transgelin

1

3

High-throughput

0.445

High

682854

Q9W0H8
Reticulocalbin-3

1

1

High-throughput

0.445

High

682858

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.445

High

682865

Q9XYZ9
Glutathione S transferase E12, isoform A

1

1

High-throughput

0.445

High

69245

A8JUU3
Secretory 16, isoform D

1

5

High-throughput

0.439

High

682774

Q95RY2
LD01461p

1

1

High-throughput

0.439

High

682760

Q8IRH7
Supercoiling factor variant B

1

1

High-throughput

0.437

High

682803

Q9VGM2
Fatty acid-binding protein, muscle

1

3

High-throughput

0.437

High

682847

Q9VWJ6
FI03615p

1

1

High-throughput

0.437

High

57743

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.426

High

121615

M9PFR6
Multiprotein bridging factor 1, isoform E

1

0

High-throughput

0.426

High

197306

O18335
Rab11

1

0

High-throughput

0.426

High

305632

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.426

High

609359

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.426

High

632938

GLNA1
Glutamine synthetase 1, mitochondrial

1

0

High-throughput

0.426

High

682729

ROP
Protein ROP

1

0

High-throughput

0.426

High

682740

Q76NR6
Regucalcin

1

0

High-throughput

0.426

High

682747

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

682754

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.426

High

682755

Q7KTW5
Inositol-1-monophosphatase

1

0

High-throughput

0.426

High

682768

Q8T0L3
E1 ubiquitin-activating enzyme

1

0

High-throughput

0.426

High

682773

FAXC
Failed axon connections

1

0

High-throughput

0.426

High

682776

Q960M4
Peroxiredoxin-5

1

0

High-throughput

0.426

High

682780

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.426

High

682782

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.426

High

682809

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.426

High

682812

Q9VII9
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.426

High

682839

WDR1
Actin-interacting protein 1

1

0

High-throughput

0.426

High

682841

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.426

High

682843

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.426

High

682856

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.426

High

682859

Q9W2M4
Farnesoic acid O-methyl transferase domain-containing protein

1

0

High-throughput

0.426

High

682861

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.426

High

682863

Q9W457
Serine hydroxymethyltransferase

1

0

High-throughput

0.426

High

682864

NSUN2
tRNA

1

0

High-throughput

0.426

High

682866

Q9XZ57
Eb1, isoform E

1

0

High-throughput

0.426

High

682868

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.426

High

682842

Q9VUQ1
RE70822p

1

1

High-throughput

0.417

High

53971

A1Z892
1-Cys peroxiredoxin

1

3

High-throughput

0.407

High

121181

ALDR
Aldo-keto reductase 1B

1

4

High-throughput

0.407

High

652721

PSA71
Proteasome subunit alpha type-7-1

1

1

High-throughput

0.407

High

682710

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.407

High

682711

PSB1
Proteasome subunit beta type-1

1

1

High-throughput

0.407

High

682718

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

1

High-throughput

0.407

High

682728

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.407

High

682731

Q0E8X8
ATP synthase F1 subunit epsilon

1

1

High-throughput

0.407

High

682737

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

2

High-throughput

0.407

High

682744

Q7JVH6
LD24696p

1

4

High-throughput

0.407

High

682749

Q7K3J0
T-complex protein 1 subunit theta

1

1

High-throughput

0.407

High

682751

Q7KKI0
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.407

High

682753

Q7KN85
ATP-citrate synthase

1

2

High-throughput

0.407

High

682757

Q8INK3
Fatty acid-binding protein, muscle

1

3

High-throughput

0.407

High

682767

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.407

High

682771

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

2

High-throughput

0.407

High

682772

VDAC
Voltage-dependent anion-selective channel

1

1

High-throughput

0.407

High

682785

THIO2
Thioredoxin-2

1

3

High-throughput

0.407

High

682786

PDIA6
Protein disulfide-isomerase A6 homolog

1

3

High-throughput

0.407

High

682787

PSA3
Proteasome subunit alpha type-3

1

3

High-throughput

0.407

High

682789

Q9V9U3
LD45254p

1

1

High-throughput

0.407

High

682793

Q9VAN7
Phosphoglycerate mutase

1

1

High-throughput

0.407

High

682797

Q9VD02
GH14779p

1

1

High-throughput

0.407

High

682798

Q9VD29
small monomeric GTPase

1

1

High-throughput

0.407

High

682800

FLNA
Filamin-A

1

4

High-throughput

0.407

High

682808

Q9VHN7
transketolase

1

1

High-throughput

0.407

High

682810

Q9VHX4
LD24679p

1

4

High-throughput

0.407

High

682814

Q9VJD4
LD24721p

1

3

High-throughput

0.407

High

682818

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

1

High-throughput

0.407

High

682821

Q9VLB7
Rab GDP dissociation inhibitor

1

1

High-throughput

0.407

High

682826

PSB4
Proteasome subunit beta type-4

1

4

High-throughput

0.407

High

682833

Q9VRL1
GEO06356p1

1

1

High-throughput

0.407

High

682844

Q9VVL7
Dihydrolipoyl dehydrogenase

1

3

High-throughput

0.407

High

682853

Q9VZY0
LD45195p

1

1

High-throughput

0.407

High

682862

CISY
Probable citrate synthase, mitochondrial

1

1

High-throughput

0.407

High

682867

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.407

High

682869

Q9Y112
BcDNA.GH10614

1

4

High-throughput

0.407

High

197730

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

2

0

High-throughput

0.298

High

476905

NDKA
Nucleoside diphosphate kinase

2

0

High-throughput

0.298

High

682727

HMGD
High mobility group protein D

2

0

High-throughput

0.298

High

682759

Q8IRD3
Glutathione peroxidase

2

0

High-throughput

0.298

High

682779

JUPIT
Microtubule-associated protein Jupiter

2

0

High-throughput

0.298

High

682805

TEBPH
Cytosolic Prostaglandin E synthase

2

0

High-throughput

0.298

High

682819

Q9VL70
HL08109p

2

0

High-throughput

0.298

High

682830

BACC
Bacchus

2

0

High-throughput

0.298

High

682795

MOC2B
Molybdopterin synthase catalytic subunit

1

0

Small-scale

0.279

Low

56305

A1ZA28
FI21960p1

1

0

High-throughput

0.265

Low

356223

O97061
Ccp84Ad

1

0

High-throughput

0.265

Low

682756

TINC
Protein tincar

1

0

High-throughput

0.265

Low

682766

Q8SY52
Elastin-like, isoform A

1

0

High-throughput

0.265

Low

682857

Q9W1H7
Putative homeodomain protein

1

0

High-throughput

0.249

Low

86456

B9EQV3
Endoplasmic reticulum transmembrane protein

1

0

High-throughput

0.232

Low

304595

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.232

Low

426626

HP1
Heterochromatin protein 1

1

0

High-throughput

0.232

Low

458080

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

0

High-throughput

0.232

Low

459989

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.232

Low

614886

SYB
Synaptobrevin

1

0

High-throughput

0.232

Low

626983

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

631722

JANA
Sex-regulated protein janus-A

1

0

High-throughput

0.232

Low

663947

PHB1
Prohibitin 1

1

0

High-throughput

0.232

Low

682713

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.232

Low

682716

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.232

Low

682720

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

682723

CYC2
Cytochrome c-2

1

0

High-throughput

0.232

Low

682725

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.232

Low

682732

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.232

Low

682734

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.232

Low

682736

ATPO
ATP synthase subunit O, mitochondrial

1

0

High-throughput

0.232

Low

682739

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.232

Low

682742

Q7JR58
Probable enoyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.232

Low

682743

Q7JR83
Hormone-sensitive lipase, isoform A

1

0

High-throughput

0.232

Low

682746

SEELE
Protein seele

1

0

High-throughput

0.232

Low

682748

Q7K148
Proteasome subunit beta

1

0

High-throughput

0.232

Low

682750

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.232

Low

682763

Q8MT58
Carnosine dipeptidase 2, isoform A

1

0

High-throughput

0.232

Low

682775

Q960C7
NADP-retinol dehydrogenase

1

0

High-throughput

0.232

Low

682777

Q961C8
LD22649p

1

0

High-throughput

0.232

Low

682784

Q9V3V9
Endonuclease G inhibitor, isoform A

1

0

High-throughput

0.232

Low

682790

Q9VA42
Niemann-Pick type C-2g, isoform A

1

0

High-throughput

0.232

Low

682791

Q9VAC1
GM14349p

1

0

High-throughput

0.232

Low

682796

Q9VCK6
LD34157p

1

0

High-throughput

0.232

Low

682801

Q9VG31
Malic enzyme

1

0

High-throughput

0.232

Low

682806

ADAL
Adenosine deaminase-like protein

1

0

High-throughput

0.232

Low

682807

Q9VHL2
T-complex protein 1 subunit eta

1

0

High-throughput

0.232

Low

682811

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.232

Low

682816

Q9VKW5
Prolyl endopeptidase

1

0

High-throughput

0.232

Low

682817

EF1D
Probable elongation factor 1-delta

1

0

High-throughput

0.232

Low

682829

Q9VQ61
Aspartate aminotransferase

1

0

High-throughput

0.232

Low

682834

Q9VRP2
Uncharacterized protein, isoform A

1

0

High-throughput

0.232

Low

682835

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.232

Low

682845

Q9VW59
Rho GDP-dissociation inhibitor 3

1

0

High-throughput

0.232

Low

682846

Q9VW70
FI21813p1

1

0

High-throughput

0.232

Low

682848

Q9VWQ7
Coactosin-like protein

1

0

High-throughput

0.232

Low

682849

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.232

Low

682850

SUN
Protein stunted

1

0

High-throughput

0.232

Low

682855

GALE
UDP-glucose 4-epimerase

1

0

High-throughput

0.232

Low

682860

Q9W3X6
fumarate hydratase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025