HitPredict

Interactor 1: BHE40 (O14503)
Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)
Gene: BHLHE40

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 197
+	Hs
		980671 HEY1_HUMAN (17-323): 9.56e-64: 208: 18.67		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980604 HES1_HUMAN (31-298): 9.29e-46: 160: 17.73		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980948 HES6_HUMAN (48-273): 1.11e-37: 137: 19.91		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		980638 HES6_HUMAN (48-273): 1.11e-37: 137: 19.91		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980840 HES6_HUMAN (48-273): 1.11e-37: 137: 19.91		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		62468 HELT_HUMAN (43-320): 1.9e-46: 161: 18.60		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Mm
		1143960 HES6_MOUSE (37-275): 4.65e-39: 141: 21.16		TLE1_MOUSE (2-197): 2.15e-101: 310: 63.00
+	Hs
		421 A0A087WSW0_HUMAN (16-320): 7.81e-43: 154: 17.28		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		993640 MLX_HUMAN (20-185): 1.47e-37: 139: 15.79		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		993550 HES6_HUMAN (48-273): 1.11e-37: 137: 19.91		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		980686 HES1_HUMAN (31-298): 9.29e-46: 160: 17.73		TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62
+	Dm
		558369 ESM3_DROME (43-265): 7.39e-51: 172: 20.61		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558377 DPN_DROME (16-268): 1.07e-48: 172: 18.01		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558371 ESMC_DROME (39-244): 5.68e-47: 161: 22.64		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		525718 ESM7_DROME (45-199): 5.43e-44: 153: 23.87		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558370 ESMB_DROME (44-238): 6.81e-44: 153: 24.37		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558372 ESMD_DROME (42-218): 7.46e-44: 152: 22.91		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		525743 ESM8_DROME (43-235): 6.74e-41: 145: 17.86		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558399 Q9VJ16_DROME (20-301): 1.7e-36: 141: 20.00		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		525705 ESM5_DROME (35-236): 8.67e-37: 133: 16.83		GROU_DROME (2-163): 3.54e-59: 198: 54.44