HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: CSF1R (P07333)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12133942
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 972
+	Hs
		426975 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		CSF1R_HUMAN (1-972): 0: 747: 100.00
+	Hs
		411943 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		CSF1R_HUMAN (1-972): 0: 747: 100.00
+	Mm
		452181 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		CSF1R_MOUSE (1-972): 0: 726: 74.57
+	Hs
		499278 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		147381 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		433226 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		454791 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		256847 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		442765 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		433221 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		PGFRB_HUMAN (22-967): 5.22e-180: 553: 31.31
+	Hs
		433274 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Hs
		454802 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Mm
		404012 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		PGFRB_MOUSE (22-967): 1.54e-176: 544: 31.64
+	Hs
		442785 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Mm
		959810 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		FLT3_MOUSE (13-953): 2.07e-173: 533: 31.11
+	Hs
		147391 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FGFR3_HUMAN (13-300): 6.13e-55: 207: 15.92
+	Hs
		433247 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		VGFR1_HUMAN (21-507): 3.44e-46: 182: 15.58
+	Hs
		433229 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGFR1_HUMAN (32-209): 4.95e-24: 110: 14.56
+	Hs
		147395 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		UFO_HUMAN (1-308): 2.37e-23: 108: 14.49
+	Mm
		403545 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		KIT_MOUSE (9-293): 5.75e-23: 107: 13.08