HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 543
+	Hs
		146668 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		YES_HUMAN (1-543): 0: 617: 100.00
+	Hs
		433215 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		YES_HUMAN (1-543): 0: 617: 100.00
+	Hs
		433231 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		SRC_HUMAN (1-543): 0: 601: 74.22
+	Hs
		454794 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		SRC_HUMAN (1-543): 0: 601: 74.22
+	Hs
		411946 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FYN_HUMAN (1-543): 0: 582: 72.16
+	Hs
		433222 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGR_HUMAN (1-542): 0: 562: 67.10
+	Hs
		454787 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		FGR_HUMAN (1-542): 0: 562: 67.10
+	Mm
		536205 FGR_MOUSE (35-223): 1.31e-48: 168: 14.55		FGR_MOUSE (1-542): 0: 561: 66.61
+	Hs
		147374 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		411552 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LCK_HUMAN (83-541): 0: 540: 60.78
+	Mm
		411932 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LCK_MOUSE (83-541): 0: 542: 60.78
+	Hs
		433216 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		433535 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		147406 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		BLK_HUMAN (66-538): 5.05e-174: 502: 59.07
+	Hs
		147369 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10
+	Hs
		147402 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		TXK_HUMAN (87-532): 3.37e-165: 480: 37.09
+	Hs
		337315 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10
+	Hs
		147422 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		PTK6_HUMAN (88-536): 9.35e-164: 474: 42.73
+	Mm
		763386 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		EPHA4_MOUSE (4-542): 1.69e-156: 473: 25.00