HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: GHR (P10912)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Gene: GHR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10585430
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005829 - cytosol GO:0045597 - positive regulation of cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 638
+	Hs
		147385 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02
+	Hs
		411991 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		IL7RA_HUMAN (127-483): 2.97e-70: 236: 21.82
+	Mm
		193372 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		EPOR_MOUSE (6-470): 4.46e-64: 221: 14.86
+	Mm
		540265 LYN_MOUSE (14-223): 3.04e-46: 161: 16.53		EPOR_MOUSE (6-470): 4.46e-64: 221: 14.86
+	Hs
		147386 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84
+	Hs
		412029 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		CNTFR_HUMAN (2-260): 9.56e-52: 184: 18.49
+	Hs
		147442 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		CSF3R_HUMAN (28-468): 1.54e-42: 166: 11.62
+	Hs
		442875 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		CSF3R_HUMAN (28-468): 1.54e-42: 166: 11.62
+	Hs
		147443 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I12R2_HUMAN (24-265): 3.34e-35: 144: 19.11
+	Hs
		412028 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		IL3RA_HUMAN (41-316): 3.09e-40: 153: 13.73
+	Hs
		147383 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IL2RB_HUMAN (53-474): 1.34e-35: 143: 13.44
+	Mm
		435879 HCK_MOUSE (14-223): 4.94e-46: 161: 15.04		CSF3R_MOUSE (32-357): 3.72e-39: 156: 12.87
+	Hs
		147403 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LEPR_HUMAN (53-315): 1.77e-30: 130: 17.87
+	Mm
		193379 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		LEPR_MOUSE (21-315): 5.43e-27: 119: 17.14
+	Mm
		817307 SOCS7_MOUSE (13-221): 4.57e-51: 175: 24.17		LEPR_MOUSE (21-315): 5.43e-27: 119: 17.14
+	Mm
		817309 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LEPR_MOUSE (21-315): 5.43e-27: 119: 17.14
+	Mm
		193384 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		IL6RB_MOUSE (68-468): 3.99e-11: 68.5: 15.25
+	Hs
		147398 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IL6RB_HUMAN (68-374): 2.53e-11: 68.8: 14.94
+	Hs
		412051 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		IL3RB_HUMAN (1-252): 1.76e-11: 69.6: 14.23
+	Hs
		442787 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		IL6RB_HUMAN (68-374): 2.53e-11: 68.8: 14.94