Protein: CAN2
Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)

Gene: CAN2, CAPN2
Organism: Homo sapiens
Interactions: 124
UniProt ID: P17655

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001666 - response to hypoxia
GO:0001824 - blastocyst development
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

457037

CAN1
Calpain-1 catalytic subunit

2

14

High-throughput

0.811

High

605965

ICAL
Calpastatin

2

5

Small-scale

0.789

High

606024

KCTD7
BTB/POZ domain-containing protein KCTD7

1

10

Small-scale

0.724

High

412927

CPNS1
Calpain small subunit 1

4

14

Small-scale

0.686

High

563143

CFTR
Cystic fibrosis transmembrane conductance regulator

3

2

High-throughput

0.662

High

529027

TAU
Microtubule-associated protein tau

2

6

Small-scale

0.619

High

605981

ATX3
Ataxin-3

2

3

Small-scale

0.602

High

605969

LSP1
Lymphocyte-specific protein 1

2

0

High-throughput

0.602

High

73993

MYO9A
Unconventional myosin-IXa

2

10

High-throughput

0.601

High

606032

AFG2B
ATPase family gene 2 protein homolog B

2

2

High-throughput

0.601

High

240687

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

606000

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

1

High-throughput

0.584

High

606014

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.582

High

605995

CAV1
Caveolin-1

2

2

High-throughput

0.571

High

606043

FXL12
F-box/LRR-repeat protein 12

2

1

Small-scale

0.571

High

606022

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

Small-scale

0.561

High

606031

ZFY21
Zinc finger FYVE domain-containing protein 21

1

1

Small-scale

0.561

High

605964

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

1

Small-scale

0.552

High

605967

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.550

High

606036

ATG5
Autophagy protein 5

1

2

Small-scale

0.550

High

228895

CF410
Cilia- and flagella-associated protein 410

1

2

High-throughput

0.536

High

605972

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.536

High

605974

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

1

High-throughput

0.536

High

605975

FNTB
Protein farnesyltransferase subunit beta

1

3

High-throughput

0.536

High

605978

JAK3
Tyrosine-protein kinase JAK3

1

1

High-throughput

0.536

High

605979

STAT2
Signal transducer and activator of transcription 2

1

3

High-throughput

0.536

High

605982

PMS1
PMS1 protein homolog 1

1

1

High-throughput

0.536

High

605992

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.536

High

605996

DMWD
Dystrophia myotonica WD repeat-containing protein

1

2

High-throughput

0.536

High

606009

CD109
CD109 antigen

1

1

High-throughput

0.536

High

606016

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

2

High-throughput

0.536

High

606025

DOCK7
Dedicator of cytokinesis protein 7

1

4

High-throughput

0.536

High

606041

DIAP3
Protein diaphanous homolog 3

1

4

High-throughput

0.536

High

606045

FMN2
Formin-2

1

1

High-throughput

0.536

High

606048

E2AK4
eIF-2-alpha kinase GCN2

1

6

High-throughput

0.536

High

606052

MCM8
DNA helicase MCM8

1

1

High-throughput

0.536

High

606057

WDR37
WD repeat-containing protein 37

1

1

High-throughput

0.536

High

605971

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

606059

LOXL2
Lysyl oxidase homolog 2

1

1

Small-scale

0.515

High

452158

PDIA1
Protein disulfide-isomerase

1

1

High-throughput

0.515

High

561884

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

605983

CASP6
Caspase-6

1

2

High-throughput

0.515

High

605987

RAN
GTP-binding nuclear protein Ran

1

3

High-throughput

0.515

High

522041

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.513

High

135882

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

0

High-throughput

0.513

High

165003

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.513

High

213563

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.513

High

289921

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.513

High

542323

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

584950

GNS
N-acetylglucosamine-6-sulfatase

1

0

High-throughput

0.513

High

605963

EGLN
Endoglin

1

0

High-throughput

0.513

High

605988

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

606003

ERC6L
DNA excision repair protein ERCC-6-like

1

0

High-throughput

0.513

High

606006

TUT4
Terminal uridylyltransferase 4

1

0

High-throughput

0.513

High

606011

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.513

High

606012

TEDC1
Tubulin epsilon and delta complex protein 1

1

0

High-throughput

0.513

High

606017

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.513

High

606030

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

0

High-throughput

0.513

High

606042

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.513

High

606058

MTO1
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial

1

0

High-throughput

0.513

High

606002

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

2

Small-scale

0.501

High

606049

DUX4
Double homeobox protein 4

1

0

High-throughput

0.494

High

247657

NUPR1
Nuclear protein 1

1

0

High-throughput

0.493

High

605985

MYPR
Myelin proteolipid protein

1

0

High-throughput

0.493

High

606005

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

1

High-throughput

0.489

High

606056

PSG8
Pregnancy-specific beta-1-glycoprotein 8

1

2

High-throughput

0.489

High

605984

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.480

High

132822

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

1

High-throughput

0.479

High

259402

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

371099

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

411312

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

484900

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

536450

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

605966

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

605968

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

1

Small-scale

0.479

High

605976

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

Small-scale

0.479

High

605977

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

605980

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.479

High

605986

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

605997

TP4A2
Protein tyrosine phosphatase type IVA 2

1

1

High-throughput

0.479

High

605999

CUL3
Cullin-3

1

7

Small-scale

0.479

High

606001

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

606008

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

606010

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

606019

DUS19
Dual specificity protein phosphatase 19

1

2

High-throughput

0.479

High

606021

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.479

High

606027

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

606037

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

606038

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

606050

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

606054

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.479

High

280492

PR40A
Pre-mRNA-processing factor 40 homolog A

1

7

High-throughput

0.470

High

486934

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

605989

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

605990

SUMO1
Small ubiquitin-related modifier 1

1

0

Small-scale

0.458

High

605991

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.458

High

605993

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

606013

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

606020

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.458

High

606046

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

161281

ENC1
Ectoderm-neural cortex protein 1

1

1

High-throughput

0.445

High

606007

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

606026

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

606055

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.445

High

105285

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

605970

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

606004

DUS28
Dual specificity phosphatase 28

1

2

High-throughput

0.437

High

606028

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

605973

FAS
Fatty acid synthase

1

0

High-throughput

0.426

High

606029

METH
Methionine synthase

1

0

High-throughput

0.426

High

606033

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.426

High

606035

TSYL1
Testis-specific Y-encoded-like protein 1

1

0

High-throughput

0.426

High

606039

TENS1
Tensin-1

1

0

Small-scale

0.426

High

606044

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

3

0

High-throughput

0.347

High

605994

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

2

0

High-throughput

0.313

High

605998

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

606015

FAM9C
Protein FAM9C

1

0

High-throughput

0.279

Low

606018

WDR36
WD repeat-containing protein 36

1

0

High-throughput

0.279

Low

606034

CSTFT
Cleavage stimulation factor subunit 2 tau variant

1

0

High-throughput

0.279

Low

606051

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.279

Low

606053

TASOR
Protein TASOR

1

0

High-throughput

0.279

Low

606047

Q9P1I4
PRO0786

1

0

High-throughput

0.268

Low

606023

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low

606040

XAGE1
X antigen family member 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025