HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: PRLR (P16471)
Prolactin receptor (PRL-R)
Gene: PRLR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11713228
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 622
+	Hs
		147383 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IL2RB_HUMAN (34-531): 2.89e-67: 231: 14.45
+	Hs
		147382 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		GHR_HUMAN (31-566): 5.33e-64: 224: 22.45
+	Hs
		433265 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EPHB2_HUMAN (28-330): 2.18e-53: 199: 12.58
+	Hs
		147442 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		CSF3R_HUMAN (14-240): 2.73e-53: 197: 22.08
+	Mm
		763386 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		EPHA4_MOUSE (27-330): 6.21e-53: 197: 12.38
+	Hs
		442875 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		CSF3R_HUMAN (14-240): 2.73e-53: 197: 22.08
+	Hs
		411991 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		IL7RA_HUMAN (108-440): 8.92e-55: 194: 19.73
+	Mm
		193372 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		EPOR_MOUSE (32-412): 5.9e-49: 180: 19.24
+	Hs
		147386 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		EPOR_HUMAN (31-449): 3.13e-49: 180: 18.59
+	Hs
		147443 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I12R2_HUMAN (20-240): 3.09e-42: 165: 22.61
+	Hs
		147398 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IL6RB_HUMAN (46-322): 9.4e-28: 121: 14.80
+	Mm
		193384 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		IL6RB_MOUSE (46-322): 1.06e-25: 114: 15.11
+	Mm
		56907 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		PTPRF_MOUSE (20-257): 2.48e-28: 123: 18.41
+	Hs
		411959 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRF_HUMAN (22-257): 4.3e-28: 122: 18.14
+	Hs
		442787 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		IL6RB_HUMAN (46-322): 9.4e-28: 121: 14.80
+	Hs
		147403 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LEPR_HUMAN (33-285): 8.05e-20: 96.5: 19.64
+	Mm
		193379 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		LEPR_MOUSE (33-275): 2.47e-18: 91.5: 19.03
+	Mm
		817307 SOCS7_MOUSE (13-221): 4.57e-51: 175: 24.17		LEPR_MOUSE (33-275): 2.47e-18: 91.5: 19.03
+	Mm
		817309 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LEPR_MOUSE (33-275): 2.47e-18: 91.5: 19.03
+	Hs
		412016 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRD_HUMAN (24-491): 1.02e-17: 89.7: 11.74