Protein: CAN3
Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1)

Gene: CAN3, CAPN3
Organism: Homo sapiens
Interactions: 53
UniProt ID: P20807

Gene Ontology (top 5):
GO:0003824 - catalytic activity
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

635060

CAN3
Calpain-3

3

14

Small-scale

0.849

High

635090

TITIN
Titin

4

6

Small-scale

0.684

High

635093

NTAQ1
Protein N-terminal glutamine amidohydrolase

3

0

High-throughput

0.646

High

635081

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

2

High-throughput

0.606

High

635083

C102B
Coiled-coil domain-containing protein 102B

2

3

High-throughput

0.606

High

635084

RUFY3
Protein RUFY3

2

4

High-throughput

0.606

High

635092

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

2

1

High-throughput

0.606

High

635085

NECA2
N-terminal EF-hand calcium-binding protein 2

1

0

High-throughput

0.589

High

635087

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.580

High

635095

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

2

0

High-throughput

0.580

High

635091

TRI63
E3 ubiquitin-protein ligase TRIM63

1

8

High-throughput

0.568

High

384624

CRYAB
Alpha-crystallin B chain

1

2

High-throughput

0.541

High

469661

MMP2
72 kDa type IV collagenase

1

3

High-throughput

0.541

High

610225

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.541

High

635064

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

635068

MYPC1
Myosin-binding protein C, slow-type

1

4

High-throughput

0.541

High

635069

UBE3A
Ubiquitin-protein ligase E3A

1

6

High-throughput

0.541

High

635071

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.541

High

635072

MYBPH
Myosin-binding protein H

1

4

High-throughput

0.541

High

635078

AMOT
Angiomotin

1

3

High-throughput

0.541

High

635088

CMYA5
Cardiomyopathy-associated protein 5

1

10

High-throughput

0.541

High

635098

RN167
E3 ubiquitin-protein ligase RNF167

1

1

High-throughput

0.541

High

635077

PPCEL
Prolyl endopeptidase-like

1

0

High-throughput

0.518

High

635094

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.518

High

635101

POMP
Proteasome maturation protein

1

0

High-throughput

0.518

High

635076

H31T
Histone H3.1t

1

2

High-throughput

0.515

High

442230

GELS
Gelsolin

1

1

High-throughput

0.515

High

561892

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

635061

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.515

High

635066

CASP6
Caspase-6

1

4

High-throughput

0.515

High

635067

RAN
GTP-binding nuclear protein Ran

1

3

High-throughput

0.515

High

635070

ECHP
Peroxisomal bifunctional enzyme

1

1

High-throughput

0.515

High

635100

UBQL1
Ubiquilin-1

1

4

High-throughput

0.515

High

635102

SHLB1
Endophilin-B1

1

5

High-throughput

0.515

High

635075

FLNC
Filamin-C

1

10

Small-scale

0.501

High

635079

FND3B
Fibronectin type III domain-containing protein 3B

1

5

High-throughput

0.494

High

635063

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

635073

BYST
Bystin

1

0

High-throughput

0.493

High

635074

VEZF1
Vascular endothelial zinc finger 1

1

0

High-throughput

0.493

High

635086

ZN410
Zinc finger protein 410

1

0

High-throughput

0.493

High

635089

CEP76
Centrosomal protein of 76 kDa

1

1

High-throughput

0.481

High

635097

TRI55
Tripartite motif-containing protein 55

1

9

High-throughput

0.481

High

400269

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

536483

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

635062

PSA3
Proteasome subunit alpha type-3

1

1

Small-scale

0.479

High

635096

TRI54
Tripartite motif-containing protein 54

1

8

High-throughput

0.479

High

280501

PR40A
Pre-mRNA-processing factor 40 homolog A

1

7

High-throughput

0.470

High

635065

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.458

High

635082

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

635099

OSGI1
Oxidative stress-induced growth inhibitor 1

2

0

High-throughput

0.327

High

505798

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

0

High-throughput

0.282

High

635080

ENPLL
Putative endoplasmin-like protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025