Protein: CAN1
Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)

Gene: CAN1, CAPN1
Organism: Homo sapiens
Interactions: 150
UniProt ID: P07384

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

457042

ICAL
Calpastatin

6

5

Small-scale

0.943

High

457123

CPNS2
Calpain small subunit 2

4

14

High-throughput

0.892

High

65512

CAN8
Calpain-8

2

14

High-throughput

0.811

High

457037

CAN2
Calpain-2 catalytic subunit

2

14

High-throughput

0.811

High

412917

CPNS1
Calpain small subunit 1

7

14

Small-scale

0.747

High

457124

KCTD7
BTB/POZ domain-containing protein KCTD7

1

10

Small-scale

0.724

High

370395

KNG1
Kininogen-1

4

2

High-throughput

0.691

High

457039

LEG3
Galectin-3

3

1

High-throughput

0.667

High

457062

FNTB
Protein farnesyltransferase subunit beta

3

3

High-throughput

0.667

High

457106

CD109
CD109 antigen

3

1

High-throughput

0.662

High

457109

KTN1
Kinectin

3

2

High-throughput

0.662

High

457027

CAN1
Calpain-1 catalytic subunit

1

13

Small-scale

0.647

High

457087

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

7

Small-scale

0.647

High

457040

PTN1
Tyrosine-protein phosphatase non-receptor type 1

3

1

Small-scale

0.643

High

457114

C99L2
CD99 antigen-like protein 2

3

0

High-throughput

0.634

High

457061

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

2

1

High-throughput

0.628

High

457093

TRIPC
E3 ubiquitin-protein ligase TRIP12

2

11

High-throughput

0.628

High

457046

MAP4
Microtubule-associated protein 4

2

8

High-throughput

0.621

High

457055

ACTN2
Alpha-actinin-2

1

2

Small-scale

0.621

High

457028

VIME
Vimentin

2

6

Small-scale

0.614

High

457029

TAU
Microtubule-associated protein tau

2

7

Small-scale

0.585

High

240512

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

451309

NFM
Neurofilament medium polypeptide

2

7

High-throughput

0.574

High

457098

AINX
Alpha-internexin

2

6

High-throughput

0.574

High

457135

TB22B
TBC1 domain family member 22B

2

7

High-throughput

0.574

High

457056

STAT3
Signal transducer and activator of transcription 3

1

3

High-throughput

0.573

High

457041

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

457081

CAV1
Caveolin-1

2

2

High-throughput

0.571

High

238354

RAD21
Double-strand-break repair protein rad21 homolog

2

0

Small-scale

0.569

High

457030

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.554

High

457064

PSN2
Presenilin-2

1

2

Small-scale

0.552

High

457128

ATG5
Autophagy protein 5

1

2

Small-scale

0.550

High

457125

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

2

3

High-throughput

0.549

High

282442

KTNA1
Katanin p60 ATPase-containing subunit A1

1

3

High-throughput

0.536

High

325265

OR2A4
Olfactory receptor 2A4

1

1

High-throughput

0.536

High

457053

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

457060

NEST
Nestin

1

8

High-throughput

0.536

High

457077

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.536

High

457078

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.536

High

457097

ZIC1
Zinc finger protein ZIC 1

1

3

High-throughput

0.536

High

457105

MPRIP
Myosin phosphatase Rho-interacting protein

1

4

High-throughput

0.536

High

457120

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

1

High-throughput

0.536

High

457133

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

1

High-throughput

0.536

High

457141

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

2

High-throughput

0.536

High

457144

PRC2C
Protein PRRC2C

1

6

High-throughput

0.536

High

185142

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.529

High

187444

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.529

High

457050

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.515

High

421318

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

457121

OPTN
Optineurin

1

3

High-throughput

0.515

High

274078

ANR17
Ankyrin repeat domain-containing protein 17

1

0

High-throughput

0.513

High

457072

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

457090

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.513

High

457112

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.513

High

457130

SYCM
Probable cysteine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

457044

IKBA
NF-kappa-B inhibitor alpha

1

3

Small-scale

0.501

High

457068

ATX3
Ataxin-3

1

2

Small-scale

0.501

High

457049

KCY
UMP-CMP kinase

1

0

High-throughput

0.493

High

457119

BAD
Bcl2-associated agonist of cell death

1

0

High-throughput

0.493

High

457095

SAFB1
Scaffold attachment factor B1

1

5

High-throughput

0.489

High

457126

WDR33
pre-mRNA 3' end processing protein WDR33

1

3

High-throughput

0.489

High

457104

CLC4G
C-type lectin domain family 4 member G

1

0

High-throughput

0.486

High

270513

SLIT3
Slit homolog 3 protein

1

1

Small-scale

0.481

High

457038

DESM
Desmin

1

6

Small-scale

0.481

High

457043

ALAT1
Alanine aminotransferase 1

1

1

Small-scale

0.481

High

457048

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

Small-scale

0.481

High

457066

CATC
Dipeptidyl peptidase 1

1

1

Small-scale

0.481

High

457075

ACTC
Actin, alpha cardiac muscle 1

1

1

Small-scale

0.481

High

457088

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

High-throughput

0.481

High

457091

FHL2
Four and a half LIM domains protein 2

1

2

Small-scale

0.481

High

457092

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

1

Small-scale

0.481

High

457094

MYPC3
Myosin-binding protein C, cardiac-type

1

5

Small-scale

0.481

High

457127

TINAL
Tubulointerstitial nephritis antigen-like

1

1

Small-scale

0.481

High

230683

GAS2
Growth arrest-specific protein 2

1

10

Small-scale

0.479

High

352857

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

370946

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

388907

FINC
Fibronectin

1

4

High-throughput

0.479

High

411196

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

413025

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

457031

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

457045

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

457051

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

1

Small-scale

0.479

High

457058

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

457059

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

457063

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

457065

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

457074

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

457076

H31
Histone H3.1

1

1

High-throughput

0.479

High

457079

FANCC
Fanconi anemia group C protein

1

1

Small-scale

0.479

High

457080

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

3

High-throughput

0.479

High

457083

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

457086

CUL3
Cullin-3

1

7

Small-scale

0.479

High

457089

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

457099

RBBP7
Histone-binding protein RBBP7

1

1

High-throughput

0.479

High

457100

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.479

High

457102

FBW10
F-box/WD repeat-containing protein 10

1

2

High-throughput

0.479

High

457107

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

457108

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

457111

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

457117

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

457118

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

457129

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

457131

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

457132

ANLN
Anillin

1

2

High-throughput

0.479

High

457137

FXL12
F-box/LRR-repeat protein 12

1

1

Small-scale

0.479

High

457138

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.479

High

457139

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

457140

XPO7
Exportin-7

1

2

High-throughput

0.479

High

457142

CE164
Centrosomal protein of 164 kDa

1

6

High-throughput

0.479

High

457143

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

162437

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.460

High

183999

S22A1
Solute carrier family 22 member 1

1

0

Small-scale

0.460

High

289209

CREG1
Protein CREG1

1

0

Small-scale

0.460

High

384085

CO1A1
Collagen alpha-1(I) chain

1

0

Small-scale

0.460

High

457036

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

Small-scale

0.460

High

457057

PTGDS
Prostaglandin-H2 D-isomerase

1

0

Small-scale

0.460

High

457070

SH3BG
SH3 domain-binding glutamic acid-rich protein

1

0

Small-scale

0.460

High

293075

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

345270

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

347472

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

376670

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

457047

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

457052

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.458

High

457096

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

457116

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

457134

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

457136

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

334143

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

2

High-throughput

0.445

High

457032

CD99
CD99 antigen

1

1

High-throughput

0.445

High

457034

EZRI
Ezrin

1

2

Small-scale

0.445

High

457067

RCAN1
Calcipressin-1

1

2

Small-scale

0.445

High

457069

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

457071

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.445

High

457101

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

457103

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

105141

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

259319

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

457035

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

457054

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

457085

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.437

High

126964

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

457033

IDE
Insulin-degrading enzyme

1

0

High-throughput

0.426

High

457073

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

Small-scale

0.426

High

457122

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.426

High

457113

RP9
Retinitis pigmentosa 9 protein

2

0

High-throughput

0.328

High

457115

COG1
Conserved oligomeric Golgi complex subunit 1

1

0

High-throughput

0.279

Low

457082

TLE5
TLE family member 5

1

0

Small-scale

0.251

Low

457084

SRSF6
Serine/arginine-rich splicing factor 6

1

0

High-throughput

0.249

Low

457110

PALB2
Partner and localizer of BRCA2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025