HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: PTK6 (Q13882)
Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK)
Gene: PTK6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22547065
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 451
+	Hs
		146668 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		YES_HUMAN (10-450): 0: 519: 42.86
+	Hs
		411946 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FYN_HUMAN (10-450): 0: 521: 42.35
+	Hs
		433231 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		SRC_HUMAN (3-450): 0: 521: 43.30
+	Hs
		147377 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		YES_HUMAN (10-450): 0: 519: 42.86
+	Hs
		433215 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		YES_HUMAN (10-450): 0: 519: 42.86
+	Hs
		147374 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LCK_HUMAN (3-449): 0: 517: 39.07
+	Hs
		411552 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LCK_HUMAN (3-449): 0: 517: 39.07
+	Hs
		454794 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		SRC_HUMAN (3-450): 0: 521: 43.30
+	Mm
		411932 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LCK_MOUSE (2-449): 0: 519: 38.99
+	Hs
		147369 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ABL1_HUMAN (1-449): 2.48e-170: 509: 35.17
+	Hs
		411559 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		LCK_HUMAN (3-449): 0: 517: 39.07
+	Hs
		433222 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGR_HUMAN (10-450): 3.32e-177: 508: 42.41
+	Hs
		433216 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LYN_HUMAN (3-449): 5.02e-177: 506: 38.19
+	Hs
		454787 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		FGR_HUMAN (10-450): 3.32e-177: 508: 42.41
+	Hs
		337315 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		ABL1_HUMAN (1-449): 2.48e-170: 509: 35.17
+	Mm
		536205 FGR_MOUSE (35-223): 1.31e-48: 168: 14.55		FGR_MOUSE (10-450): 7.33e-177: 506: 42.63
+	Hs
		433535 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		LYN_HUMAN (3-449): 5.02e-177: 506: 38.19
+	Hs
		147406 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		BLK_HUMAN (7-449): 2e-169: 487: 39.51
+	Hs
		147402 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		TXK_HUMAN (7-448): 6.88e-159: 461: 32.53