Protein: MPDZ
Multiple PDZ domain protein (Multi-PDZ domain protein 1)

Gene: MPDZ
Organism: Homo sapiens
Interactions: 96
UniProt ID: O75970

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0005923 - bicellular tight junction
GO:0014069 - postsynaptic density
GO:0016324 - apical plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

299772

PALS1
Protein PALS1

3

17

High-throughput

0.871

High

299801

LIN7C
Protein lin-7 homolog C

3

20

High-throughput

0.861

High

167672

LIN7A
Protein lin-7 homolog A

2

20

High-throughput

0.811

High

299765

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

2

20

Small-scale

0.776

High

299791

LIN7B
Protein lin-7 homolog B

2

20

High-throughput

0.776

High

299749

YAP1
Transcriptional coactivator YAP1

6

20

Small-scale

0.735

High

299764

AMOT
Angiomotin

5

20

Small-scale

0.720

High

299723

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

4

High-throughput

0.691

High

299748

CRK
Adapter molecule crk

1

14

High-throughput

0.691

High

299775

PARD3
Partitioning defective 3 homolog

1

19

High-throughput

0.691

High

299788

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

4

High-throughput

0.691

High

299739

5HT2C
5-hydroxytryptamine receptor 2C

3

20

Small-scale

0.672

High

299793

PKHA2
Pleckstrin homology domain-containing family A member 2

3

20

Small-scale

0.672

High

299782

RN166
E3 ubiquitin-protein ligase RNF166

3

20

High-throughput

0.667

High

299794

PKHA1
Pleckstrin homology domain-containing family A member 1

2

20

Small-scale

0.643

High

299806

AMOL2
Angiomotin-like protein 2

2

20

High-throughput

0.628

High

299766

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

299795

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

299763

KIF14
Kinesin-like protein KIF14

2

20

High-throughput

0.611

High

299769

KIBRA
Protein KIBRA

2

20

Small-scale

0.611

High

281701

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.578

High

299787

O2AG1
Olfactory receptor 2AG1

1

2

Small-scale

0.578

High

299741

SSR3
Somatostatin receptor type 3

1

20

Small-scale

0.573

High

299726

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

299804

DAPLE
Protein Daple

1

12

Small-scale

0.561

High

249541

SNX3
Sorting nexin-3

1

1

High-throughput

0.536

High

299722

PKHG5
Pleckstrin homology domain-containing family G member 5

1

20

High-throughput

0.536

High

299733

VINC
Vinculin

1

7

High-throughput

0.536

High

299735

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.536

High

299747

MK09
Mitogen-activated protein kinase 9

1

14

High-throughput

0.536

High

299760

ASPP2
Apoptosis-stimulating of p53 protein 2

1

17

High-throughput

0.536

High

299761

KIF22
Kinesin-like protein KIF22

1

20

High-throughput

0.536

High

299770

AMOL1
Angiomotin-like protein 1

1

20

High-throughput

0.536

High

299784

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.536

High

299785

LZTS2
Leucine zipper putative tumor suppressor 2

1

18

High-throughput

0.536

High

299799

KIF15
Kinesin-like protein KIF15

1

18

High-throughput

0.536

High

299802

ABI2
Abl interactor 2

1

16

High-throughput

0.536

High

299808

TACC3
Transforming acidic coiled-coil-containing protein 3

1

10

High-throughput

0.536

High

299731

KIT
Mast/stem cell growth factor receptor Kit

1

7

Small-scale

0.527

High

299797

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.515

High

299732

XRCC5
X-ray repair cross-complementing protein 5

1

0

High-throughput

0.513

High

299767

SAPC2
Suppressor APC domain-containing protein 2

1

0

High-throughput

0.513

High

299777

OSCP1
Protein OSCP1

1

0

High-throughput

0.513

High

299790

WDR54
WD repeat-containing protein 54

1

0

High-throughput

0.513

High

299751

MTR1A
Melatonin receptor type 1A

1

20

High-throughput

0.508

High

299738

5HT2A
5-hydroxytryptamine receptor 2A

1

20

Small-scale

0.501

High

299742

OR1D2
Olfactory receptor 1D2

1

1

Small-scale

0.501

High

299743

CRFR1
Corticotropin-releasing factor receptor 1

1

20

Small-scale

0.501

High

299746

5HT2B
5-hydroxytryptamine receptor 2B

1

20

Small-scale

0.501

High

299750

OR3A1
Olfactory receptor 3A1

1

3

Small-scale

0.501

High

299798

CLTR2
Cysteinyl leukotriene receptor 2

1

20

High-throughput

0.501

High

299728

P53
Cellular tumor antigen p53

1

4

Small-scale

0.500

High

66782

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

1

High-throughput

0.489

High

299740

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.489

High

299759

GOGA2
Golgin subfamily A member 2

1

14

High-throughput

0.489

High

299768

F124A
Protein FAM124A

1

2

High-throughput

0.489

High

299771

ZN664
Zinc finger protein 664

1

4

High-throughput

0.489

High

299774

RASF8
Ras association domain-containing protein 8

1

7

High-throughput

0.489

High

299776

RN138
E3 ubiquitin-protein ligase RNF138

1

20

High-throughput

0.489

High

299778

WASF1
Actin-binding protein WASF1

1

7

High-throughput

0.489

High

299745

DRD3
D(3) dopamine receptor

1

20

Small-scale

0.481

High

298994

FLOT1
Flotillin-1

1

9

High-throughput

0.479

High

299721

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

299724

ABCA1
Phospholipid-transporting ATPase ABCA1

1

3

Small-scale

0.479

High

299725

LATS1
Serine/threonine-protein kinase LATS1

1

20

High-throughput

0.479

High

299734

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

20

High-throughput

0.479

High

299737

GCSP
Glycine dehydrogenase

1

3

High-throughput

0.479

High

299744

CTNB1
Catenin beta-1

1

20

High-throughput

0.479

High

299753

GSK3A
Glycogen synthase kinase-3 alpha

1

7

High-throughput

0.479

High

299754

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.479

High

299755

VASP
Vasodilator-stimulated phosphoprotein

1

15

High-throughput

0.479

High

299756

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

299757

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

299758

PRDX1
Peroxiredoxin-1

1

3

High-throughput

0.479

High

299762

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

299779

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

299786

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

299789

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.479

High

299796

E41LA
Band 4.1-like protein 4A

1

19

High-throughput

0.479

High

299800

RN146
E3 ubiquitin-protein ligase RNF146

1

5

Small-scale

0.479

High

299805

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

299809

DUS10
Dual specificity protein phosphatase 10

1

5

High-throughput

0.479

High

299803

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

299773

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.445

High

299780

CSN5
COP9 signalosome complex subunit 5

1

6

Small-scale

0.445

High

273245

T22D2
TSC22 domain family protein 2

1

4

Small-scale

0.439

High

299727

ALDOA
Fructose-bisphosphate aldolase A

1

5

High-throughput

0.437

High

299729

ALDOC
Fructose-bisphosphate aldolase C

1

5

High-throughput

0.437

High

299736

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

20

High-throughput

0.437

High

299781

CK052
Uncharacterized protein C11orf52

1

7

High-throughput

0.437

High

299807

MAFB
Transcription factor MafB

1

1

High-throughput

0.437

High

65667

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.279

Low

299792

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

0

Small-scale

0.251

Low

299752

CEBPD
CCAAT/enhancer-binding protein delta

1

0

Small-scale

0.249

Low

299783

KTI12
Protein KTI12 homolog

1

0

Small-scale

0.249

Low

299730

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025