HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 30166453, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 1298
+	Hs
		146646 SOCS2_HUMAN (3-221): 1.16e-46: 154: 28.31		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		1319011 CISH_HUMAN (13-221): 1.55e-45: 153: 30.62		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		147558 SOCS6_HUMAN (15-220): 4.58e-39: 143: 22.64		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		181893 SOCS1_HUMAN (19-221): 4.01e-37: 130: 25.98		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		412300 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		SNR40_HUMAN (45-329): 6.16e-55: 197: 11.75
+	Hs
		181906 SOCS1_HUMAN (19-221): 4.01e-37: 130: 25.98		WSB1_HUMAN (57-256): 4.52e-15: 81.3: 13.51