HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.966

Property	Details
Experiments	26186194, 28514442, 28883622, 33961781, 21030588, 31253590, 21145461
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 780
+	Mm
		1322060 SOCS6_MOUSE (1-535): 0: 677: 84.39		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		146692 SOCS7_HUMAN (370-535): 6e-45: 168: 53.57		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1257617 SOCS7_MOUSE (370-535): 3.92e-45: 169: 53.57		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		146642 SOCS2_HUMAN (344-535): 7.98e-46: 161: 30.81		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		256856 SOCS5_HUMAN (370-535): 5.17e-40: 154: 36.53		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		411713 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		1274062 CISH_HUMAN (329-535): 6.59e-42: 152: 24.68		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		181885 SOCS1_HUMAN (379-535): 5.8e-42: 151: 26.75		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		1263831 SOCS4_HUMAN (370-535): 2.52e-39: 150: 36.53		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		193366 SOCS2_MOUSE (344-535): 5.68e-44: 156: 29.29		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		1143676 CISH_MOUSE (321-535): 7.54e-43: 155: 24.69		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		222648 SOCS5_MOUSE (370-535): 1.02e-39: 153: 36.53		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		1265273 SOCS4_MOUSE (370-535): 1.24e-39: 151: 36.53		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		193357 SOCS1_MOUSE (379-535): 2.14e-41: 149: 26.75		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		1042817 VAV3_HUMAN (284-484): 7.2e-44: 168: 21.23		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		1043054 TENS3_HUMAN (161-475): 7.47e-45: 171: 18.08		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		1028467 SLAP1_HUMAN (302-531): 1.48e-45: 163: 15.16		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		146625 SOCS2_HUMAN (344-535): 7.98e-46: 161: 30.81		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		1041477 CISH_HUMAN (329-535): 6.59e-42: 152: 24.68		CUL2_HUMAN (6-780): 0: 699: 26.36
+	Hs
		181856 SOCS1_HUMAN (379-535): 5.8e-42: 151: 26.75		CUL2_HUMAN (6-780): 0: 699: 26.36