Protein: CBS
Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) (Sulfur transfer protein 4)

Gene: CBS, CYS4
Organism: Saccharomyces cerevisiae S288C
Interactions: 116
UniProt ID: P32582

Gene Ontology (top 5):
GO:0003729 - mRNA binding
GO:0004122 - cystathionine beta-synthase activity
GO:0004124 - cysteine synthase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

365997

HSP82
ATP-dependent molecular chaperone HSP82

3

9

Small-scale

0.633

High

478023

HSP77
Import motor subunit, mitochondrial

2

5

High-throughput

0.611

High

693770

HSP7F
Heat shock protein homolog SSE1

2

9

High-throughput

0.601

High

543408

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.584

High

693802

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

693769

CBS
Cystathionine beta-synthase

1

19

Small-scale

0.575

High

680543

HS104
Heat shock protein 104

2

5

High-throughput

0.571

High

493487

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

693798

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.552

High

627834

SIS1
Protein SIS1

2

3

High-throughput

0.549

High

339522

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.536

High

539325

KSS1
Mitogen-activated protein kinase KSS1

1

4

High-throughput

0.536

High

560604

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

614583

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.536

High

693825

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.536

High

367872

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.515

High

439999

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.515

High

454250

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.515

High

555912

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.515

High

693818

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

3

High-throughput

0.515

High

416292

SIR3
Regulatory protein SIR3

1

0

High-throughput

0.513

High

599963

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.513

High

664404

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

680014

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

High-throughput

0.513

High

693793

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.500

High

693794

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

2

High-throughput

0.500

High

360807

TBB
Tubulin beta chain

1

0

High-throughput

0.493

High

693778

SLD2
DNA replication regulator SLD2

1

0

High-throughput

0.493

High

693787

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.493

High

693801

ERR3
Enolase-related protein 3

1

0

High-throughput

0.493

High

693820

WAR1
Weak acid resistance protein 1

1

0

High-throughput

0.493

High

693834

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.479

High

141227

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

406897

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

482154

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

524228

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

631751

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

693773

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

693774

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.479

High

693779

TCTP
Translationally-controlled tumor protein homolog

1

1

High-throughput

0.479

High

693780

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

693783

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

693806

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

693813

HST2
NAD-dependent protein deacetylase HST2

1

1

High-throughput

0.479

High

693819

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

636041

CSM1
Monopolin complex subunit CSM1

1

1

High-throughput

0.464

High

693814

RHO5
GTP-binding protein RHO5

1

0

Small-scale

0.460

High

340640

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

413388

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

420048

TYSY
Thymidylate synthase

1

0

High-throughput

0.458

High

634233

GID7
Glucose-induced degradation protein 7

1

0

High-throughput

0.458

High

693772

TCA17
TRAPP-associated protein TCA17

1

0

Small-scale

0.458

High

693775

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

693791

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

693795

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

693797

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.458

High

693800

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

693807

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.458

High

693809

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

693811

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.458

High

693817

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

693785

TCD1
tRNA threonylcarbamoyladenosine dehydratase 1

1

2

High-throughput

0.457

High

539964

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.457

High

586380

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.457

High

449965

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.445

High

490675

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

510655

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

541651

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.445

High

633054

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

693786

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

693796

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

693803

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

693804

DPH4
Diphthamide biosynthesis protein 4

1

2

High-throughput

0.445

High

693816

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.445

High

693812

YG3A
Uncharacterized protein YGR130C

1

0

High-throughput

0.438

High

693833

RTN2
Reticulon-like protein 2

1

0

High-throughput

0.438

High

357955

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

383025

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

405508

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

470940

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

472091

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

645332

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

661675

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

693792

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

693821

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.437

High

693827

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

693828

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

693805

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

693815

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

693822

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.426

High

693831

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

693790

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.407

High

693830

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.288

High

693777

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

0

High-throughput

0.282

High

419320

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.279

Low

420557

SPT2
Protein SPT2

1

0

High-throughput

0.279

Low

550531

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.279

Low

644792

RFA3
Replication factor A protein 3

1

0

High-throughput

0.279

Low

693789

TEM1
Protein TEM1

1

0

High-throughput

0.279

Low

693799

SEC24
Protein transport protein SEC24

1

0

High-throughput

0.279

Low

693808

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

693823

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

495811

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.269

Low

693771

STH1
Nuclear protein STH1/NPS1

1

0

High-throughput

0.269

Low

629543

CDC10
Cell division control protein 10

1

0

High-throughput

0.261

Low

693832

ATG5
Autophagy protein 5

1

0

High-throughput

0.261

Low

693776

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

693781

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

693782

GID4
Vacuolar import and degradation protein 24

1

0

High-throughput

0.249

Low

693784

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.249

Low

693788

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

693810

DRN1
CWF19-like protein DRN1

1

0

High-throughput

0.249

Low

693824

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

693826

EXP1
ER export of PMA1 protein 1

1

0

High-throughput

0.249

Low

693829

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024