HitPredict

Interactor 1: Q9VKW8 (Q9VKW8)
U6 snRNA-associated Sm-like protein LSm4
Gene: CG5356

Interactor 2: Q9VTW6 (Q9VTW6)
U6 snRNA-associated Sm-like protein LSm2
Gene: DmelCG10418

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0000932 - P-body GO:0005681 - spliceosomal complex GO:0005688 - U6 snRNP GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 154 Dm			1 95
+	Hs
		1491049 LSM4_HUMAN (1-88): 1.04e-40: 134: 88.64		LSM2_HUMAN (1-95): 1.9e-35: 117: 91.58
+	Zm
		38968 A0A1D6MPT6_MAIZE (1-112): 9.41e-41: 136: 68.75		A0A1D6MPT6_MAIZE (1-92): 2.44e-33: 115: 27.17
+	Hs
		974498 LSM4_HUMAN (1-88): 1.04e-40: 134: 88.64		SMD1_HUMAN (1-95): 8.67e-28: 99.2: 28.42
+	Hs
		974495 SMD1_HUMAN (1-90): 1.11e-29: 106: 27.96		LSM2_HUMAN (1-95): 1.9e-35: 117: 91.58
+	Hs
		974878 LSM4_HUMAN (1-88): 1.04e-40: 134: 88.64		SMD3_HUMAN (2-88): 5.93e-23: 86.9: 21.84
+	Hs
		974094 LSM4_HUMAN (1-88): 1.04e-40: 134: 88.64		RUXF_HUMAN (3-71): 1.13e-22: 85: 31.43
+	Sp
		153961 LSM4_SCHPO (1-88): 3.94e-33: 115: 61.80		LSM4_SCHPO (1-89): 1.53e-27: 98.5: 28.09
+	Dm
		232190 SMD3_DROME (2-105): 1.46e-29: 107: 29.81		SMD1_DROME (1-94): 5.29e-28: 99.6: 29.79
+	Hs
		974353 SMD3_HUMAN (2-105): 3.33e-30: 107: 31.73		SMD1_HUMAN (1-95): 8.67e-28: 99.2: 28.42
+	Dm
		232172 SMD3_DROME (2-105): 1.46e-29: 107: 29.81		RUXF_DROME (3-84): 1.06e-23: 87.7: 26.83
+	Dm
		1173252 SMD1_DROME (1-90): 8.29e-30: 106: 25.81		RUXF_DROME (3-84): 1.06e-23: 87.7: 26.83
+	Hs
		973874 SMD3_HUMAN (2-105): 3.33e-30: 107: 31.73		RUXF_HUMAN (3-71): 1.13e-22: 85: 31.43
+	Hs
		973872 SMD1_HUMAN (1-90): 1.11e-29: 106: 27.96		RUXF_HUMAN (3-71): 1.13e-22: 85: 31.43
+	Hs
		974806 SMD3_HUMAN (2-105): 3.33e-30: 107: 31.73		LSM10_HUMAN (3-87): 1.41e-21: 83.4: 25.88
+	Hs
		974087 LSM2_HUMAN (1-88): 2.36e-28: 102: 34.78		RUXF_HUMAN (3-71): 1.13e-22: 85: 31.43