Protein: LSM4
U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)

Gene: LSM4
Organism: Homo sapiens
Interactions: 154
UniProt ID: Q9Y4Z0

Gene Ontology (top 5):
GO:0000387 - spliceosomal snRNP assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0000932 - P-body
GO:0000956 - nuclear-transcribed mRNA catabolic process
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1460921

LSM7
U6 snRNA-associated Sm-like protein LSm7

9

20

Small-scale

0.972

High

178060

LSM1
U6 snRNA-associated Sm-like protein LSm1

7

20

Small-scale

0.957

High

1137209

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

6

20

High-throughput

0.945

High

974350

LSM6
U6 snRNA-associated Sm-like protein LSm6

6

19

Small-scale

0.940

High

344583

LSM8
U6 snRNA-associated Sm-like protein LSm8

6

20

Small-scale

0.940

High

215217

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

5

8

High-throughput

0.919

High

974301

LSM3
U6 snRNA-associated Sm-like protein LSm3

5

20

Small-scale

0.912

High

1491049

LSM2
U6 snRNA-associated Sm-like protein LSm2

5

16

Small-scale

0.912

High

1287163

PATL1
Protein PAT1 homolog 1

5

6

Small-scale

0.908

High

1491471

LSM5
U6 snRNA-associated Sm-like protein LSm5

4

20

High-throughput

0.892

High

974705

SMD2
Small nuclear ribonucleoprotein Sm D2

3

20

High-throughput

0.861

High

991277

RSMN
Small nuclear ribonucleoprotein-associated protein N

3

19

High-throughput

0.861

High

973858

RUXE
Small nuclear ribonucleoprotein E

3

15

High-throughput

0.858

High

926252

ICLN
Methylosome subunit pICln

2

10

High-throughput

0.811

High

974094

RUXF
Small nuclear ribonucleoprotein F

2

20

High-throughput

0.789

High

473220

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

13

High-throughput

0.754

High

1138815

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

12

High-throughput

0.754

High

209361

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

5

20

High-throughput

0.718

High

286512

WBP4
WW domain-binding protein 4

1

6

High-throughput

0.691

High

480366

RU1C
U1 small nuclear ribonucleoprotein C

1

6

High-throughput

0.691

High

574533

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

17

High-throughput

0.691

High

974878

SMD3
Small nuclear ribonucleoprotein Sm D3

1

14

High-throughput

0.691

High

162746

ANM5
Protein arginine N-methyltransferase 5

4

4

Small-scale

0.683

High

1095865

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

4

0

High-throughput

0.675

High

220824

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

3

1

High-throughput

0.675

High

1271938

MEPCE
7SK snRNA methylphosphate capping enzyme

3

5

High-throughput

0.656

High

1410417

MEP50
Methylosome protein WDR77

3

20

High-throughput

0.650

High

974498

SMD1
Small nuclear ribonucleoprotein Sm D1

1

14

High-throughput

0.618

High

1241870

PRP8
Pre-mRNA-processing-splicing factor 8

1

8

High-throughput

0.618

High

321707

PRP6
Pre-mRNA-processing factor 6

2

17

High-throughput

0.611

High

478273

SNRPA
U1 small nuclear ribonucleoprotein A

2

20

High-throughput

0.611

High

1109255

PRP4K
Serine/threonine-protein kinase PRP4 homolog

2

4

High-throughput

0.611

High

1491260

RBGP1
Rab GTPase-activating protein 1

2

3

High-throughput

0.611

High

1491398

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

4

Small-scale

0.611

High

1384055

EXOS8
Exosome complex component RRP43

2

4

High-throughput

0.606

High

542298

TOP1
DNA topoisomerase 1

2

3

Small-scale

0.602

High

1411780

RIOK1
Serine/threonine-protein kinase RIO1

2

3

High-throughput

0.601

High

1434920

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

2

2

High-throughput

0.601

High

1446875

COPRS
Coordinator of PRMT5 and differentiation stimulator

2

1

High-throughput

0.601

High

1491406

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

2

4

High-throughput

0.601

High

85324

RBG10
Rab GTPase-activating protein 1-like, isoform 10

3

1

Small-scale

0.599

High

1160631

SMN
Survival motor neuron protein

2

8

Small-scale

0.595

High

216300

PPIH
Peptidyl-prolyl cis-trans isomerase H

2

6

High-throughput

0.584

High

1387663

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

2

14

High-throughput

0.584

High

1316496

XRN1
5'-3' exoribonuclease 1

2

2

High-throughput

0.576

High

91664

PATL2
Protein PAT1 homolog 2

1

5

Small-scale

0.575

High

1104707

IKZF1
DNA-binding protein Ikaros

1

1

High-throughput

0.573

High

1462252

RHG26
Rho GTPase-activating protein 26

2

1

High-throughput

0.571

High

258398

GAS7
Growth arrest-specific protein 7

2

1

High-throughput

0.553

High

1208999

RBG1L
Rab GTPase-activating protein 1-like

2

2

High-throughput

0.552

High

1387866

ZBT10
Zinc finger and BTB domain-containing protein 10

1

0

High-throughput

0.549

High

1395267

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

0

High-throughput

0.549

High

212355

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

2

High-throughput

0.536

High

274401

SIN3B
Paired amphipathic helix protein Sin3b

1

1

High-throughput

0.536

High

286123

SF3B1
Splicing factor 3B subunit 1

1

5

High-throughput

0.536

High

471953

RU2B
U2 small nuclear ribonucleoprotein B''

1

16

High-throughput

0.536

High

483280

CLCA
Clathrin light chain A

1

3

High-throughput

0.536

High

483423

CLCB
Clathrin light chain B

1

3

High-throughput

0.536

High

775394

FUS
RNA-binding protein FUS

1

16

High-throughput

0.536

High

1065514

SSRP1
FACT complex subunit SSRP1

1

7

High-throughput

0.536

High

1094665

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

High-throughput

0.536

High

1127284

RBM39
RNA-binding protein 39

1

10

High-throughput

0.536

High

1136517

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

1148680

SF3A2
Splicing factor 3A subunit 2

1

7

High-throughput

0.536

High

1149238

SF3A1
Splicing factor 3A subunit 1

1

7

High-throughput

0.536

High

1160357

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

10

High-throughput

0.536

High

1287910

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

4

High-throughput

0.536

High

1359966

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

9

High-throughput

0.536

High

1387321

TMCO6
Transmembrane and coiled-coil domain-containing protein 6

1

1

High-throughput

0.536

High

1413436

RBM42
RNA-binding protein 42

1

13

High-throughput

0.536

High

1438958

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

4

High-throughput

0.536

High

183987

S22A2
Solute carrier family 22 member 2

1

0

High-throughput

0.518

High

1332976

ZN511
Zinc finger protein 511

1

0

High-throughput

0.513

High

1180267

SMU1
WD40 repeat-containing protein SMU1

1

12

High-throughput

0.508

High

1392119

TOE1
Target of EGR1 protein 1

1

2

High-throughput

0.508

High

508896

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

1101250

NMI
N-myc-interactor

1

0

High-throughput

0.486

High

1410998

RHXF2
Rhox homeobox family member 2

1

0

High-throughput

0.486

High

1437693

PKHA5
Pleckstrin homology domain-containing family A member 5

1

3

High-throughput

0.481

High

158032

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

163853

TCRG1
Transcription elongation regulator 1

1

7

High-throughput

0.479

High

173609

XPO1
Exportin-1

1

6

High-throughput

0.479

High

257288

PQBP1
Polyglutamine-binding protein 1

1

1

High-throughput

0.479

High

260652

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

289739

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

20

High-throughput

0.479

High

316216

RECQ4
ATP-dependent DNA helicase Q4

1

13

High-throughput

0.479

High

325193

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

373610

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

406848

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

482567

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

535710

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

684447

DDX6
Probable ATP-dependent RNA helicase DDX6

1

10

Small-scale

0.479

High

696971

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

769613

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

791874

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

800191

COIL
Coilin

1

2

High-throughput

0.479

High

831713

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

872937

SOX2
Transcription factor SOX-2

1

7

Small-scale

0.479

High

914007

RBM5
RNA-binding protein 5

1

4

High-throughput

0.479

High

965372

WDR5
WD repeat-containing protein 5

1

20

High-throughput

0.479

High

980607

H4
Histone H4

1

4

High-throughput

0.479

High

981200

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1111391

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.479

High

1142041

EEA1
Early endosome antigen 1

1

5

High-throughput

0.479

High

1159061

RBBP7
Histone-binding protein RBBP7

1

6

Small-scale

0.479

High

1194490

LARP7
La-related protein 7

1

12

High-throughput

0.479

High

1199486

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

3

High-throughput

0.479

High

1206587

PRC2B
Protein PRRC2B

1

5

High-throughput

0.479

High

1241531

EDC4
Enhancer of mRNA-decapping protein 4

1

1

Small-scale

0.479

High

1290205

THOC4
THO complex subunit 4

1

6

High-throughput

0.479

High

1290862

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.479

High

1324933

RHG18
Rho GTPase-activating protein 18

1

5

High-throughput

0.479

High

1327487

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

7

Small-scale

0.479

High

1336340

LS14A
Protein LSM14 homolog A

1

6

Small-scale

0.479

High

1360318

GEMI6
Gem-associated protein 6

1

4

High-throughput

0.479

High

1361269

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.479

High

1367685

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1367766

PRCC
Proline-rich protein PRCC

1

1

High-throughput

0.479

High

1393986

FUBP3
Far upstream element-binding protein 3

1

1

High-throughput

0.479

High

1397602

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1414636

DDX23
Probable ATP-dependent RNA helicase DDX23

1

13

High-throughput

0.479

High

1421042

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

1436585

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1451594

GEMI8
Gem-associated protein 8

1

3

High-throughput

0.479

High

1453193

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

1453886

AKA7G
A-kinase anchor protein 7 isoform gamma

1

5

High-throughput

0.479

High

1459448

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1459964

DDX20
Probable ATP-dependent RNA helicase DDX20

1

15

High-throughput

0.479

High

1461942

FZR1
Fizzy-related protein homolog

1

14

High-throughput

0.479

High

1462408

RL26L
Ribosomal protein uL24-like

1

1

High-throughput

0.479

High

1462516

PHF8
Histone lysine demethylase PHF8

1

1

High-throughput

0.479

High

1490652

FBW1A
F-box/WD repeat-containing protein 1A

1

14

High-throughput

0.479

High

1490969

WBP11
WW domain-binding protein 11

1

1

High-throughput

0.479

High

1491182

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

6

High-throughput

0.479

High

1311801

HOMEZ
Homeobox and leucine zipper protein Homez

1

0

High-throughput

0.460

High

168346

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

Small-scale

0.458

High

352613

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

601919

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

938000

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

985590

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.458

High

1089079

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1210564

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.458

High

1244851

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1435721

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

1448132

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1449603

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

3683

NBDY
Negative regulator of P-body association

1

1

Small-scale

0.445

High

530660

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

931627

RD23A
UV excision repair protein RAD23 homolog A

1

1

High-throughput

0.445

High

1119390

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

2

High-throughput

0.445

High

1420783

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

224433

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

5

High-throughput

0.407

High

1400956

SIM14
Small integral membrane protein 14

1

0

High-throughput

0.265

Low

528533

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025