HitPredict

Interactor 1: UTY (O14607)
Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY)
Gene: UTY

Interactor 2: ASH2L (Q9UBL3)
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
Gene: ASH2L

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24981860, 37974198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0044666 - MLL3/4 complex GO:0046872 - metal ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1347 Hs			1 628
+	Hs
		183170 KDM6A_HUMAN (1-1347): 0: 1425: 83.29		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		183162 KDM6A_HUMAN (1-1347): 0: 1425: 83.29		CSR2B_HUMAN (61-327): 3.08e-65: 230: 17.75
+	Hs
		165879 KDM6B_HUMAN (391-1345): 0: 859: 38.61		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		175277 OGT1_HUMAN (165-614): 1.63e-32: 139: 10.07		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		1057010 MDC1_HUMAN (457-1023): 4.41e-15: 83.1: 11.02		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Dm
		114489 M9PCJ7_DROME (9-155): 3.25e-10: 67: 17.69		ASH2_DROME (87-621): 0: 541: 48.07
+	Hs
		1056849 MDC1_HUMAN (457-1023): 4.41e-15: 83.1: 11.02		HNRL2_HUMAN (270-581): 8.58e-54: 198: 19.41