HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12650946
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription GO:0007411 - axon guidance GO:0035556 - intracellular signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 552
+	Mm
		844412 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD4_MOUSE (1-552): 0: 688: 98.37
+	Mm
		844410 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD1_MOUSE (20-546): 0: 544: 34.72
+	Hs
		150710 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD1_HUMAN (20-546): 0: 542: 34.91
+	Hs
		150693 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22
+	Mm
		844423 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD2_MOUSE (19-549): 1.86e-167: 485: 28.65
+	Hs
		150709 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD2_HUMAN (19-549): 1.81e-166: 482: 28.65
+	Hs
		150947 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22
+	Hs
		1035517 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD4_HUMAN (1-552): 0: 696: 100.00
+	Hs
		876396 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		SMAD2_HUMAN (19-549): 1.81e-166: 482: 28.65
+	Mm
		192484 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD7_MOUSE (33-137): 2.38e-25: 110: 28.45
+	Hs
		1078635 NEB2_HUMAN (75-423): 2.81e-47: 181: 15.34		SMAD2_HUMAN (19-549): 1.81e-166: 482: 28.65
+	Hs
		150650 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD7_HUMAN (33-137): 4.06e-26: 112: 28.45
+	Hs
		1078579 RIMS1_HUMAN (8-675): 6.11e-45: 175: 14.18		SMAD2_HUMAN (19-549): 1.81e-166: 482: 28.65
+	Hs
		1078732 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD1_HUMAN (20-546): 0: 542: 34.91
+	Hs
		950340 GRIP1_HUMAN (163-625): 8.94e-21: 99: 12.70		SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22
+	Hs
		950226 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22
+	Hs
		1078596 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD2_HUMAN (19-549): 1.81e-166: 482: 28.65
+	Mm
		1164093 NEB2_MOUSE (75-423): 2.88e-48: 184: 15.62		PCLO_MOUSE (130-306): 7.33e-12: 70.7: 10.99
+	Hs
		1200041 RIMS1_HUMAN (8-675): 6.11e-45: 175: 14.18		PCLO_HUMAN (133-321): 1.93e-09: 63: 14.73
+	Hs
		167376 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD7_HUMAN (33-137): 4.06e-26: 112: 28.45