HitPredict

Interactor 1: GOSR2 (O14653)
Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin)
Gene: GOSR2

Interactor 2: VAMP4 (O75379)
Vesicle-associated membrane protein 4 (VAMP-4)
Gene: VAMP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~V-SNARE_C
Common GO terms	GO:0000139 - Golgi membrane GO:0005794 - Golgi apparatus GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Hs			1 141
+	Hs
		261703 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00
+	Dm
		1178131 GOSR2_DROME (1-211): 5.02e-53: 171: 41.12		Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42
+	At
		221565 VTI11_ARATH (1-191): 2.81e-50: 164: 14.36		VA711_ARATH (7-138): 8.21e-36: 124: 23.49
+	Dm
		577252 GOSR2_DROME (1-211): 5.02e-53: 171: 41.12		SYB_DROME (24-135): 9.5e-32: 112: 26.79
+	Hs
		261737 VTI1B_HUMAN (2-190): 7.6e-44: 148: 14.36		VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00
+	Mm
		291513 VTI1B_MOUSE (2-210): 1.26e-49: 162: 14.88		VAMP7_MOUSE (15-139): 2.4e-33: 118: 28.00
+	Dm
		1178140 Q9W0N6_DROME (1-212): 7.2e-45: 150: 17.89		Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42
+	Rn
		1144366 VTI1A_RAT (2-211): 8.36e-52: 168: 12.09		VAMP1_RAT (32-125): 5.09e-29: 103: 31.92
+	Hs
		151537 GOSR2_HUMAN (1-212): 5.78e-61: 191: 100.00		VAMP5_HUMAN (52-118): 5.78e-18: 75.8: 31.34
+	Hs
		850604 VTI1B_HUMAN (2-190): 7.6e-44: 148: 14.36		VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20
+	Hs
		1079397 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10
+	Hs
		1284295 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		VAMP8_HUMAN (41-120): 1.87e-25: 94.3: 27.50
+	Dm
		577264 Q9W0N6_DROME (1-212): 7.2e-45: 150: 17.89		SYB_DROME (24-135): 9.5e-32: 112: 26.79
+	Hs
		306842 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		VAMP5_HUMAN (52-118): 5.78e-18: 75.8: 31.34
+	Hs
		1079465 VTI1B_HUMAN (2-190): 7.6e-44: 148: 14.36		VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10
+	Hs
		1313462 VTI1B_HUMAN (2-190): 7.6e-44: 148: 14.36		VAMP8_HUMAN (41-120): 1.87e-25: 94.3: 27.50
+	Sc
		979398 VTI1_YEAST (3-194): 1.99e-36: 128: 10.55		NYV1_YEAST (11-136): 5.27e-27: 102: 25.00
+	Sc
		605872 VTI1_YEAST (3-194): 1.99e-36: 128: 10.55		SEC22_YEAST (23-133): 3.08e-25: 97: 17.12
+	Hs
		306885 VTI1B_HUMAN (2-190): 7.6e-44: 148: 14.36		VAMP5_HUMAN (52-118): 5.78e-18: 75.8: 31.34
+	Sc
		704536 VTI1_YEAST (3-194): 1.99e-36: 128: 10.55		SNC2_YEAST (42-120): 1.73e-25: 95.1: 30.38