HitPredict

Interactor 1: GOSR2 (O14653)
Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin)
Gene: GOSR2

Interactor 2: STX12 (Q86Y82)
Syntaxin-12
Gene: STX12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~V-SNARE_C
Common GO terms	GO:0000139 - Golgi membrane GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0005654 - nucleoplasm GO:0005794 - Golgi apparatus and 2 others more... GO:0006906 - vesicle fusion GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Hs			1 276
+	Hs
		151576 GOSR2_HUMAN (1-212): 5.78e-61: 191: 100.00		STX1A_HUMAN (17-273): 6.81e-67: 211: 23.19
+	Ce
		183452 GOSR2_CAEEL (1-210): 3.97e-58: 184: 32.70		STX1A_CAEEL (4-276): 2.41e-67: 212: 23.38
+	Hs
		1205352 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		STX12_HUMAN (1-257): 2.32e-67: 212: 100.00
+	Mm
		292714 VTI1A_MOUSE (2-211): 6.63e-55: 176: 12.38		Q8BH40_MOUSE (8-272): 2.98e-63: 201: 51.70
+	Dm
		1098107 GOSR2_DROME (1-211): 5.02e-53: 171: 41.12		STX1A_DROME (4-273): 6.4e-64: 204: 22.10
+	Hs
		151531 GOSR2_HUMAN (1-212): 5.78e-61: 191: 100.00		STX7_HUMAN (8-272): 1.12e-55: 181: 51.70
+	Hs
		151566 GOSR2_HUMAN (1-212): 5.78e-61: 191: 100.00		STX4_HUMAN (6-272): 1.25e-53: 177: 24.27
+	At
		1352079 VTI12_ARATH (1-210): 7.47e-53: 171: 14.87		SYP42_ARATH (2-273): 1.6e-59: 193: 21.79
+	At
		955689 VTI12_ARATH (1-210): 7.47e-53: 171: 14.87		SYP22_ARATH (1-258): 1.52e-59: 191: 24.43
+	At
		249589 VTI12_ARATH (1-210): 7.47e-53: 171: 14.87		SYP41_ARATH (2-273): 4.62e-58: 189: 21.07
+	Hs
		152170 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		STX16_HUMAN (6-250): 1.6e-56: 186: 25.00
+	At
		955690 VTI11_ARATH (1-191): 2.81e-50: 164: 14.36		SYP22_ARATH (1-258): 1.52e-59: 191: 24.43
+	At
		1352078 VTI12_ARATH (1-210): 7.47e-53: 171: 14.87		SYP43_ARATH (2-273): 2.11e-55: 183: 20.00
+	At
		249590 VTI11_ARATH (1-191): 2.81e-50: 164: 14.36		SYP41_ARATH (2-273): 4.62e-58: 189: 21.07
+	Hs
		178716 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		STX7_HUMAN (8-272): 1.12e-55: 181: 51.70
+	Dm
		1178794 GOSR2_DROME (1-211): 5.02e-53: 171: 41.12		Q7K0X9_DROME (21-274): 3.74e-54: 178: 31.84
+	At
		1352080 VTI11_ARATH (1-191): 2.81e-50: 164: 14.36		SYP43_ARATH (2-273): 2.11e-55: 183: 20.00
+	At
		1107361 VTI11_ARATH (1-191): 2.81e-50: 164: 14.36		SYP21_ARATH (1-258): 7.63e-55: 180: 27.88
+	Dm
		1373152 GOSR2_DROME (1-211): 5.02e-53: 171: 41.12		Q9VU45_DROME (13-269): 2.95e-49: 166: 28.41
+	Dm
		1372996 GOSR2_DROME (1-211): 5.02e-53: 171: 41.12		Q9VR90_DROME (166-256): 7.07e-11: 63.5: 36.26