Protein: CAF40
Protein CAF40 (40 kDa CCR4-associated factor)

Gene: CAF40
Organism: Saccharomyces cerevisiae S288C
Interactions: 83
UniProt ID: P53829

Gene Ontology (top 5):
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 - P-body
GO:0005634 - nucleus
GO:0017148 - negative regulation of translation
GO:0030015 - CCR4-NOT core complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678987

NOT1
General negative regulator of transcription subunit 1

14

3

Small-scale

0.982

High

923737

CAF40
Protein CAF40

2

2

Small-scale

0.793

High

809055

POP2
Poly(A) ribonuclease POP2

12

5

Small-scale

0.760

High

726235

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

11

5

Small-scale

0.759

High

761129

NOT4
General negative regulator of transcription subunit 4

14

2

Small-scale

0.758

High

438159

NOT2
General negative regulator of transcription subunit 2

9

7

Small-scale

0.751

High

923751

NOT5
General negative regulator of transcription subunit 5

9

4

Small-scale

0.751

High

438324

NOT3
General negative regulator of transcription subunit 3

7

4

Small-scale

0.747

High

919289

CF130
Protein CAF130

8

0

Small-scale

0.717

High

923738

NST1
Stress response protein NST1

3

0

High-throughput

0.632

High

545784

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.601

High

776626

DEF1
RNA polymerase II degradation factor 1

2

0

High-throughput

0.588

High

677276

MET14
Karyogamy protein KAR4

2

0

High-throughput

0.587

High

757747

PIN4
RNA-binding protein PIN4

2

0

High-throughput

0.587

High

923745

WHI4
Protein WHI4

2

1

High-throughput

0.555

High

707805

TF2B
Transcription initiation factor IIB

2

0

High-throughput

0.551

High

672117

PUF4
Pumilio homology domain family member 4

1

5

High-throughput

0.541

High

809467

MPT5
Suppressor protein MPT5

1

5

High-throughput

0.541

High

812095

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.541

High

923750

PUF2
mRNA-binding protein PUF2

1

5

High-throughput

0.541

High

722140

XPO1
Exportin-1

1

2

High-throughput

0.536

High

740428

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.518

High

818030

LSM4
LSM complex subunit LSM4

1

0

High-throughput

0.518

High

921123

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.518

High

645961

DBF2
Cell cycle protein kinase DBF2

1

1

Small-scale

0.508

High

794325

PBP2
PAB1-binding protein 2

1

1

High-throughput

0.508

High

923741

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

1

Small-scale

0.508

High

923744

CDD
Cytidine deaminase

1

1

High-throughput

0.508

High

733674

GLNA
Glutamine synthetase

1

0

High-throughput

0.493

High

673117

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.486

High

923743

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.486

High

923748

RPIA
Ribose-5-phosphate isomerase

1

0

High-throughput

0.486

High

574724

KSS1
Mitogen-activated protein kinase KSS1

1

0

High-throughput

0.480

High

741041

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

1

High-throughput

0.479

High

745828

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

803156

ECM29
Proteasome component ECM29

1

1

High-throughput

0.479

High

822213

NACB2
Nascent polypeptide-associated complex subunit beta-2

1

1

Small-scale

0.479

High

864489

MTR4
ATP-dependent RNA helicase DOB1

1

1

Small-scale

0.479

High

616440

SEC18
Vesicular-fusion protein SEC18

1

2

High-throughput

0.464

High

636679

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.458

High

721396

MCM4
DNA replication licensing factor MCM4

1

0

Small-scale

0.458

High

735947

PSA5
Proteasome subunit alpha type-5

1

0

High-throughput

0.458

High

747974

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

750744

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

798568

HSM3
DNA mismatch repair protein HSM3

1

0

High-throughput

0.458

High

800855

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.458

High

849942

BLM10
Proteasome activator BLM10

1

0

High-throughput

0.458

High

922167

PAP2
Poly(A) RNA polymerase protein 2

1

0

Small-scale

0.458

High

923742

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

923749

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

760658

WHI3
Protein WHI3

1

1

High-throughput

0.457

High

524739

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

527332

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

742913

HSP79
Heat shock protein homolog SSE2

1

2

High-throughput

0.445

High

803636

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.445

High

819412

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

721647

RENT1
ATP-dependent helicase NAM7

1

1

Small-scale

0.439

High

918261

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.438

High

531370

METK1
S-adenosylmethionine synthase 1

1

1

Small-scale

0.437

High

621389

METK2
S-adenosylmethionine synthase 2

1

1

Small-scale

0.437

High

824760

MLP2
Protein MLP2

1

1

Small-scale

0.437

High

923739

MLP1
Protein MLP1

1

1

Small-scale

0.437

High

486272

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

670979

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

806484

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.426

High

811364

CAJ1
Protein CAJ1

1

0

High-throughput

0.426

High

807833

SSN2
Mediator of RNA polymerase II transcription subunit 13

2

0

Small-scale

0.313

High

736580

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.282

High

803231

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.265

Low

923747

HUA2
Protein HUA2

1

0

High-throughput

0.265

Low

623911

MYO2
Myosin-2

1

0

Small-scale

0.251

Low

753257

MFT1
THO complex subunit MFT1

1

0

Small-scale

0.249

Low

850330

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

0

High-throughput

0.249

Low

865215

YJY1
Uncharacterized protein YJR011C

1

0

High-throughput

0.249

Low

923740

NU100
Nucleoporin NUP100/NSP100

1

0

Small-scale

0.249

Low

923746

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.249

Low

386813

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

453722

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

579835

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.232

Low

592410

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

755140

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.232

Low

836822

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025