Protein: MTR4
ATP-dependent RNA helicase DOB1 (EC 3.6.4.13) (mRNA transport regulator MTR4)

Gene: MTR4
Organism: Saccharomyces cerevisiae S288C
Interactions: 219
UniProt ID: P47047

Gene Ontology (top 5):
GO:0000292 - RNA fragment catabolic process
GO:0000460 - maturation of 5.8S rRNA
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003724 - RNA helicase activity
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

864553

RRP6
Exosome complex exonuclease RRP6

8

5

Small-scale

0.960

High

864510

DHR1
Probable ATP-dependent RNA helicase DHR1

4

19

Small-scale

0.873

High

864559

DBP10
ATP-dependent RNA helicase DBP10

3

19

Small-scale

0.827

High

864507

HAS1
ATP-dependent RNA helicase HAS1

2

18

Small-scale

0.776

High

823352

UTP18
U3 small nucleolar RNA-associated protein 18

2

0

Small-scale

0.773

High

864485

PAP2
Poly(A) RNA polymerase protein 2

14

6

Small-scale

0.762

High

864470

TRF5
Poly(A) RNA polymerase protein 1

8

6

Small-scale

0.754

High

782078

RL1D1
Ribosome biogenesis protein UTP30

2

4

Small-scale

0.754

High

793493

MAK5
ATP-dependent RNA helicase MAK5

2

17

Small-scale

0.754

High

804723

RRP4
Exosome complex component RRP4

2

11

Small-scale

0.754

High

817590

UTP7
U3 small nucleolar RNA-associated protein 7

2

20

Small-scale

0.754

High

864490

CSL4
Exosome complex component CSL4

2

3

High-throughput

0.754

High

864511

UTP15
U3 small nucleolar RNA-associated protein 15

2

19

Small-scale

0.754

High

864520

UTP13
U3 small nucleolar RNA-associated protein 13

2

20

Small-scale

0.754

High

864528

UTP4
U3 small nucleolar RNA-associated protein 4

2

20

Small-scale

0.754

High

864562

AIR2
Protein AIR2

8

9

Small-scale

0.751

High

864549

NOP53
Ribosome biogenesis protein NOP53

6

3

Small-scale

0.736

High

825617

AIR1
Protein AIR1

4

8

Small-scale

0.687

High

444560

DED1
ATP-dependent RNA helicase DED1

1

13

High-throughput

0.665

High

864464

MTR4
ATP-dependent RNA helicase DOB1

1

16

High-throughput

0.665

High

864476

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

16

High-throughput

0.665

High

782369

RPF2
Ribosome biogenesis protein RPF2

3

1

Small-scale

0.650

High

798254

ENP1
Essential nuclear protein 1

3

3

High-throughput

0.640

High

844517

UTP10
U3 small nucleolar RNA-associated protein 10

3

1

Small-scale

0.640

High

864482

PESC
Pescadillo homolog

3

4

Small-scale

0.640

High

864503

NOG1
Nucleolar GTP-binding protein 1

3

4

Small-scale

0.640

High

864514

UTP14
U3 small nucleolar RNA-associated protein 14

3

2

Small-scale

0.640

High

808761

NAB3
Nuclear polyadenylated RNA-binding protein 3

2

1

High-throughput

0.621

High

594447

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.618

High

632573

DBP3
ATP-dependent RNA helicase DBP3

1

14

Small-scale

0.618

High

666494

DBP2
ATP-dependent RNA helicase DBP2

1

10

Small-scale

0.618

High

678414

PWP2
Periodic tryptophan protein 2

1

18

High-throughput

0.618

High

682328

SPB4
ATP-dependent rRNA helicase SPB4

1

17

Small-scale

0.618

High

746641

DRS1
ATP-dependent RNA helicase DRS1

1

17

Small-scale

0.618

High

754300

DCA13
Protein SOF1

1

20

High-throughput

0.618

High

781629

DBP7
ATP-dependent RNA helicase DBP7

1

17

Small-scale

0.618

High

792123

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.618

High

803882

CIC1
Proteasome-interacting protein CIC1

1

4

Small-scale

0.618

High

829943

PRP17
Pre-mRNA-processing factor 17

1

20

Small-scale

0.618

High

852572

ROK1
ATP-dependent RNA helicase ROK1

1

14

High-throughput

0.618

High

864487

DBP6
ATP-dependent RNA helicase DBP6

1

15

Small-scale

0.618

High

864491

SQS1
Protein SQS1

1

1

Small-scale

0.618

High

864504

UTP17
NET1-associated nuclear protein 1

1

13

High-throughput

0.618

High

864515

ERB1
Ribosome biogenesis protein ERB1

1

13

Small-scale

0.618

High

864522

DBP9
ATP-dependent RNA helicase DBP9

1

17

Small-scale

0.618

High

864525

RRP9
Ribosomal RNA-processing protein 9

1

20

High-throughput

0.618

High

864537

RRP40
Exosome complex component RRP40

1

4

High-throughput

0.618

High

864547

YTM1
Ribosome biogenesis protein YTM1

1

20

Small-scale

0.618

High

864561

RUVB2
RuvB-like protein 2

1

5

High-throughput

0.618

High

672909

RRP43
Exosome complex component RRP43

2

3

High-throughput

0.601

High

864556

MAK21
Ribosome biogenesis protein MAK21

2

2

Small-scale

0.601

High

617407

GBB
Guanine nucleotide-binding protein subunit beta

1

20

High-throughput

0.595

High

677466

KRR1
KRR1 small subunit processome component

2

4

High-throughput

0.584

High

758385

UTP11
U3 small nucleolar RNA-associated protein 11

2

1

Small-scale

0.584

High

864478

LSG1
Large subunit GTPase 1

2

7

Small-scale

0.584

High

864480

UTP22
U3 small nucleolar RNA-associated protein 22

2

1

Small-scale

0.584

High

864481

RRP46
Exosome complex component RRP46

2

17

Small-scale

0.584

High

864488

NOG2
Nucleolar GTP-binding protein 2

2

7

Small-scale

0.584

High

864492

NOP13
Nucleolar protein 13

2

15

Small-scale

0.584

High

864500

UTP6
U3 small nucleolar RNA-associated protein 6

2

5

Small-scale

0.584

High

864509

UTP5
U3 small nucleolar RNA-associated protein 5

2

16

Small-scale

0.584

High

864518

RRP45
Exosome complex component RRP45

2

16

Small-scale

0.584

High

864521

UTP21
U3 small nucleolar RNA-associated protein 21

2

16

Small-scale

0.584

High

864526

NOC4
Nucleolar complex protein 4

2

2

High-throughput

0.584

High

392968

HSP82
ATP-dependent molecular chaperone HSP82

2

12

High-throughput

0.571

High

579655

HSC82
ATP-dependent molecular chaperone HSC82

2

12

High-throughput

0.571

High

670879

SIS1
Protein SIS1

2

9

High-throughput

0.571

High

763585

UTP20
U3 small nucleolar RNA-associated protein 20

2

0

Small-scale

0.559

High

806537

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

Small-scale

0.559

High

864483

UTP8
U3 small nucleolar RNA-associated protein 8

2

0

Small-scale

0.559

High

864486

MPP6
M-phase phosphoprotein 6 homolog

2

0

Small-scale

0.559

High

792856

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.554

High

513522

RL1A
Large ribosomal subunit protein uL1A

1

7

High-throughput

0.553

High

864471

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.553

High

527049

HSP72
Heat shock protein SSA2

2

15

High-throughput

0.552

High

819134

SSB2
Ribosome-associated molecular chaperone SSB2

2

15

High-throughput

0.552

High

755126

GCN1
eIF-2-alpha kinase activator GCN1

2

11

High-throughput

0.537

High

545396

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.536

High

742887

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.536

High

864472

RL4B
Large ribosomal subunit protein uL4B

1

5

High-throughput

0.536

High

864484

NRD1
Protein NRD1

1

2

High-throughput

0.536

High

747451

RSSA1
Small ribosomal subunit protein uS2A

2

4

High-throughput

0.521

High

403562

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

15

High-throughput

0.515

High

864473

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.515

High

864474

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

19

High-throughput

0.515

High

864541

RRS1
Regulator of ribosome biosynthesis

1

2

High-throughput

0.515

High

864555

YRA1
RNA annealing protein YRA1

1

15

High-throughput

0.515

High

712607

RL8B
Large ribosomal subunit protein eL8B

1

10

High-throughput

0.514

High

720949

PSO2
DNA cross-link repair protein PSO2/SNM1

1

0

High-throughput

0.493

High

740806

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

High-throughput

0.493

High

864502

RPM2
Ribonuclease P protein component, mitochondrial

1

0

Small-scale

0.480

High

435195

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

438150

NOT2
General negative regulator of transcription subunit 2

1

3

Small-scale

0.479

High

438726

SC160
Protein SCP160

1

20

High-throughput

0.479

High

441992

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

512522

RS6A
Small ribosomal subunit protein eS6A

1

6

High-throughput

0.479

High

534121

MAK16
Protein MAK16

1

1

Small-scale

0.479

High

676744

GBP2
Serine/arginine

1

13

Small-scale

0.479

High

689068

RL16A
Large ribosomal subunit protein uL13A

1

4

High-throughput

0.479

High

689540

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.479

High

694150

CDC15
Cell division control protein 15

1

10

High-throughput

0.479

High

694582

SPT5
Transcription elongation factor SPT5

1

5

High-throughput

0.479

High

707504

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

735051

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

739985

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

4

High-throughput

0.479

High

747025

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

5

High-throughput

0.479

High

750105

MRT4
Ribosome assembly factor MRT4

1

5

Small-scale

0.479

High

761123

NOT4
General negative regulator of transcription subunit 4

1

1

Small-scale

0.479

High

780281

EBP2
rRNA-processing protein EBP2

1

2

Small-scale

0.479

High

802255

RS20
Small ribosomal subunit protein uS10

1

5

High-throughput

0.479

High

804936

LRP1
Exosome complex protein LRP1

1

1

High-throughput

0.479

High

805061

RPF1
Ribosome production factor 1

1

1

Small-scale

0.479

High

807676

HRB1
Serine/arginine

1

13

Small-scale

0.479

High

814338

NOC2
Nucleolar complex protein 2

1

1

Small-scale

0.479

High

816856

NUG1
Nuclear GTP-binding protein NUG1

1

7

Small-scale

0.479

High

826623

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

827543

RLP7
Ribosome biogenesis protein RLP7

1

5

Small-scale

0.479

High

863109

RRP41
Exosome complex component SKI6

1

20

High-throughput

0.479

High

864466

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

2

High-throughput

0.479

High

864468

MTR3
Exosome complex component MTR3

1

1

High-throughput

0.479

High

864477

NSA1
Ribosome biogenesis protein NSA1

1

1

Small-scale

0.479

High

864489

CAF40
Protein CAF40

1

1

Small-scale

0.479

High

864494

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.479

High

864495

NOP15
Ribosome biogenesis protein 15

1

18

High-throughput

0.479

High

864496

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

4

High-throughput

0.479

High

864498

NOP3
Serine/arginine

1

20

Small-scale

0.479

High

864501

MLP1
Protein MLP1

1

13

High-throughput

0.479

High

864505

ESP1
Separin

1

1

High-throughput

0.479

High

864506

TOM1
E3 ubiquitin-protein ligase TOM1

1

14

High-throughput

0.479

High

864508

ARX1
Probable metalloprotease ARX1

1

3

Small-scale

0.479

High

864516

RRP5
rRNA biogenesis protein RRP5

1

20

High-throughput

0.479

High

864517

FCF1
rRNA-processing protein FCF1

1

2

High-throughput

0.479

High

864531

RLP24
Ribosome biogenesis protein RLP24

1

2

Small-scale

0.479

High

864532

RCL1
rRNA processing protein RCL1

1

1

High-throughput

0.479

High

864533

RRP44
Exosome complex exonuclease DIS3

1

9

High-throughput

0.479

High

864534

NOP12
Nucleolar protein 12

1

20

Small-scale

0.479

High

864535

BRX1
Ribosome biogenesis protein BRX1

1

6

Small-scale

0.479

High

864542

NCBP2
Nuclear cap-binding protein subunit 2

1

18

High-throughput

0.479

High

864544

BMS1
Ribosome biogenesis protein BMS1

1

5

High-throughput

0.479

High

864545

TMA46
Translation machinery-associated protein 46

1

3

High-throughput

0.479

High

864546

MDN1
Midasin

1

2

Small-scale

0.479

High

864551

SAS10
Something about silencing protein 10

1

1

High-throughput

0.479

High

864554

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

864557

UTP12
U3 small nucleolar RNA-associated protein 12

1

17

High-throughput

0.479

High

864558

RRP42
Exosome complex component RRP42

1

16

High-throughput

0.479

High

864560

NOP56
Nucleolar protein 56

1

7

High-throughput

0.479

High

864563

NOP58
Nucleolar protein 58

1

7

High-throughput

0.479

High

864565

NOP14
Nucleolar complex protein 14

1

1

High-throughput

0.479

High

619367

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.470

High

510975

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.458

High

627802

PYRC
Dihydroorotase

1

0

High-throughput

0.458

High

673197

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

780688

RRP14
Ribosomal RNA-processing protein 14

1

0

Small-scale

0.458

High

795727

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

806629

RIX1
Pre-rRNA-processing protein RIX1

1

0

Small-scale

0.458

High

818244

NSA2
Ribosome biogenesis protein NSA2

1

0

Small-scale

0.458

High

818315

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

825059

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

825533

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

826192

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

836182

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.458

High

864467

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

864523

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

864524

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

864527

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

864530

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

864539

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

864543

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

Small-scale

0.458

High

864548

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

864550

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

864564

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

864566

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

864536

RBX1
RING-box protein HRT1

1

5

High-throughput

0.457

High

453667

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

524400

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

676124

MAS5
Mitochondrial protein import protein MAS5

1

10

High-throughput

0.445

High

741876

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

752446

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.445

High

779553

LHS1
Heat shock protein 70 homolog LHS1

1

16

High-throughput

0.445

High

807103

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.445

High

810718

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.445

High

810840

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.445

High

816277

HSP7E
Heat shock protein SSC3, mitochondrial

1

9

High-throughput

0.445

High

864465

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.445

High

864475

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.445

High

864497

H3
Histone H3

1

15

High-throughput

0.445

High

864519

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

20

High-throughput

0.445

High

410213

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.437

High

455140

RS19A
Small ribosomal subunit protein eS19A

1

7

High-throughput

0.437

High

503124

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504292

RL31A
Large ribosomal subunit protein eL31A

1

7

High-throughput

0.437

High

513092

RS8A
Small ribosomal subunit protein eS8A

1

4

High-throughput

0.437

High

514022

RL18B
Large ribosomal subunit protein eL18B

1

2

High-throughput

0.437

High

558787

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

570063

RL3
Large ribosomal subunit protein uL3

1

3

Small-scale

0.437

High

762922

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

4

High-throughput

0.437

High

778408

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.437

High

808520

TEM1
Protein TEM1

1

1

High-throughput

0.437

High

812444

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

824906

TM108
Protein TMA108

1

3

High-throughput

0.437

High

864499

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.437

High

864512

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.437

High

864529

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.437

High

864538

SKI7
Superkiller protein 7

1

3

High-throughput

0.437

High

864540

RS10A
Small ribosomal subunit protein eS10A

1

6

High-throughput

0.437

High

864552

ATG9
Autophagy-related protein 9

1

2

High-throughput

0.437

High

427341

RLA0
Large ribosomal subunit protein uL10

1

5

High-throughput

0.407

High

577167

SEC63
Protein translocation protein SEC63

1

8

High-throughput

0.407

High

671658

SCJ1
DnaJ-related protein SCJ1

1

6

High-throughput

0.407

High

863628

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

864469

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.407

High

864479

JAC1
J-type co-chaperone JAC1, mitochondrial

1

4

High-throughput

0.407

High

864493

PFD4
Prefoldin subunit 4

1

2

High-throughput

0.407

High

864513

PFD5
Prefoldin subunit 5

1

2

High-throughput

0.407

High

635973

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.269

Low

361002

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.249

Low

723619

MLS1
Malate synthase 1

1

0

High-throughput

0.249

Low

793618

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025