HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: WDR5B (Q86VZ2)
WD repeat-containing protein 5B
Gene: WDR5B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	16603732
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 330
+	Hs
		152622 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		WDR5_HUMAN (2-286): 4.02e-95: 287: 29.21
+	Hs
		152678 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		FBXW7_HUMAN (1-319): 1.47e-88: 281: 28.40
+	Hs
		903444 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		WDR5_HUMAN (2-286): 4.02e-95: 287: 29.21
+	Hs
		1281314 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		FBXW7_HUMAN (1-319): 1.47e-88: 281: 28.40
+	Hs
		1080207 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		FBXW7_HUMAN (1-319): 1.47e-88: 281: 28.40
+	Dm
		1129076 SET1_DROME (5244-5537): 1.28e-75: 284: 28.49		WDS_DROME (2-286): 9.88e-95: 286: 29.90
+	At
		1319861 ATX1_ARATH (5318-5537): 4.41e-68: 255: 33.20		WDR5A_ARATH (77-329): 3.23e-75: 235: 31.03
+	Hs
		209441 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		PLRG1_HUMAN (158-328): 2.42e-40: 149: 28.66
+	Hs
		203735 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		DAW1_HUMAN (202-330): 2.71e-32: 126: 29.46
+	Hs
		903149 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		WDR5_HUMAN (2-286): 4.02e-95: 287: 29.21
+	Hs
		975303 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		FBXW7_HUMAN (1-319): 1.47e-88: 281: 28.40
+	Hs
		903604 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		WDR5_HUMAN (2-286): 4.02e-95: 287: 29.21
+	Hs
		165657 SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15		WDR5_HUMAN (2-286): 4.02e-95: 287: 29.21
+	Hs
		903609 SET1B_HUMAN (5404-5537): 1.82e-21: 106: 48.89		WDR5_HUMAN (2-286): 4.02e-95: 287: 29.21
+	Sc
		744551 SET1_YEAST (5160-5537): 1.76e-83: 303: 27.25		SWD3_YEAST (30-205): 2.08e-14: 74.7: 28.21
+	Sp
		195053 SET1_SCHPO (5320-5537): 5.36e-66: 247: 34.30		SWD3_SCHPO (162-326): 1.98e-12: 69.3: 30.30
+	Hs
		975304 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		SNR40_HUMAN (197-329): 1.9e-28: 114: 27.61
+	Hs
		1288387 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		SNR40_HUMAN (197-329): 1.9e-28: 114: 27.61
+	Hs
		1288292 NSD3_HUMAN (175-329): 6.17e-23: 111: 17.79		SNR40_HUMAN (197-329): 1.9e-28: 114: 27.61
+	Hs
		331862 NSD2_HUMAN (175-334): 9.23e-17: 91: 17.37		SNR40_HUMAN (197-329): 1.9e-28: 114: 27.61