Protein: OXSR1
Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)

Gene: OXSR1
Organism: Homo sapiens
Interactions: 143
UniProt ID: O95747

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

343644

WNK1
Serine/threonine-protein kinase WNK1

4

20

Small-scale

0.909

High

343537

OXSR1
Serine/threonine-protein kinase OSR1

3

18

Small-scale

0.839

High

343633

WNK4
Serine/threonine-protein kinase WNK4

2

19

Small-scale

0.799

High

343662

WNK2
Serine/threonine-protein kinase WNK2

2

19

High-throughput

0.799

High

240391

PRKN
E3 ubiquitin-protein ligase parkin

2

16

High-throughput

0.754

High

158392

RFXK
DNA-binding protein RFXANK

1

9

High-throughput

0.691

High

343541

LGI1
Leucine-rich glioma-inactivated protein 1

1

4

High-throughput

0.691

High

343563

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.691

High

343567

FRK
Tyrosine-protein kinase FRK

1

20

High-throughput

0.691

High

343568

BAG6
Large proline-rich protein BAG6

1

11

High-throughput

0.691

High

343571

RBM25
RNA-binding protein 25

1

7

High-throughput

0.691

High

343639

WNK3
Serine/threonine-protein kinase WNK3

1

19

High-throughput

0.691

High

343653

DNJB9
DnaJ homolog subfamily B member 9

1

8

High-throughput

0.691

High

343655

DNJ5B
DnaJ homolog subfamily C member 5B

1

7

High-throughput

0.691

High

343629

TR19L
Tumor necrosis factor receptor superfamily member 19L

4

5

High-throughput

0.691

High

343597

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.681

High

343616

RELL2
RELT-like protein 2

5

5

High-throughput

0.662

High

343561

AKT1
RAC-alpha serine/threonine-protein kinase

1

19

Small-scale

0.647

High

343623

TITIN
Titin

1

1

High-throughput

0.647

High

343661

CAB39
Calcium-binding protein 39

1

6

Small-scale

0.647

High

343540

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

2

High-throughput

0.628

High

343544

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

3

High-throughput

0.628

High

74425

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

5

High-throughput

0.618

High

343599

CEA16
Cell adhesion molecule CEACAM16

1

4

High-throughput

0.618

High

343606

DEFI8
Differentially expressed in FDCP 8 homolog

1

12

High-throughput

0.618

High

343659

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

3

High-throughput

0.618

High

156809

CTRO
Citron Rho-interacting kinase

1

18

High-throughput

0.618

High

343543

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

343545

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

343565

TGFR1
TGF-beta receptor type-1

1

14

Small-scale

0.618

High

343566

TGFR2
TGF-beta receptor type-2

1

14

Small-scale

0.618

High

343575

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

343576

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

343589

SQSTM
Sequestosome-1

1

5

High-throughput

0.618

High

343595

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

2

High-throughput

0.618

High

343605

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.618

High

343608

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

343622

SSH1
Protein phosphatase Slingshot homolog 1

1

6

High-throughput

0.618

High

343645

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.618

High

343562

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

343596

ELOB
Elongin-B

1

0

High-throughput

0.586

High

343559

PML
Protein PML

2

9

High-throughput

0.584

High

231544

PRKY
Putative serine/threonine-protein kinase PRKY

1

18

High-throughput

0.575

High

343548

ACM4
Muscarinic acetylcholine receptor M4

1

1

High-throughput

0.575

High

343600

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

13

High-throughput

0.575

High

343612

FXL16
F-box/LRR-repeat protein 16

1

5

High-throughput

0.575

High

343624

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.575

High

343610

RELL1
RELT-like protein 1

2

5

High-throughput

0.574

High

343621

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

1

High-throughput

0.574

High

343551

HSP7C
Heat shock cognate 71 kDa protein

2

13

High-throughput

0.571

High

343602

A16L1
Autophagy-related protein 16-1

2

18

High-throughput

0.571

High

144219

ACACB
Acetyl-CoA carboxylase 2

1

10

High-throughput

0.536

High

238998

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.536

High

343539

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

343542

DYR
Dihydrofolate reductase

1

1

High-throughput

0.536

High

343552

PRG2
Bone marrow proteoglycan

1

2

High-throughput

0.536

High

343556

GSTM3
Glutathione S-transferase Mu 3

1

1

High-throughput

0.536

High

343557

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.536

High

343570

ARL4D
ADP-ribosylation factor-like protein 4D

1

12

High-throughput

0.536

High

343572

HSP72
Heat shock-related 70 kDa protein 2

1

13

High-throughput

0.536

High

343581

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

9

High-throughput

0.536

High

343583

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

4

High-throughput

0.536

High

343586

ACACA
Acetyl-CoA carboxylase 1

1

10

High-throughput

0.536

High

343587

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

343611

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

4

High-throughput

0.536

High

343615

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.536

High

343619

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

9

High-throughput

0.536

High

343626

DPF1
Zinc finger protein neuro-d4

1

5

High-throughput

0.536

High

343630

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

343634

TCPQM
T-complex protein 1 subunit theta-like 2

1

20

High-throughput

0.536

High

343635

CDC5L
Cell division cycle 5-like protein

1

10

High-throughput

0.536

High

343640

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

343646

BAFL
Barrier-to-autointegration factor-like protein

1

1

High-throughput

0.536

High

343650

ARL15
ADP-ribosylation factor-like protein 15

1

9

High-throughput

0.536

High

343658

TRI35
E3 ubiquitin-protein ligase TRIM35

1

9

High-throughput

0.536

High

343663

WIF1
Wnt inhibitory factor 1

1

3

High-throughput

0.536

High

343591

CUL4A
Cullin-4A

1

7

Small-scale

0.527

High

343592

CUL4B
Cullin-4B

1

7

Small-scale

0.527

High

343647

WDR6
tRNA

1

16

Small-scale

0.527

High

343555

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

343594

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.513

High

343604

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

343609

RIP
RPA-interacting protein

1

0

High-throughput

0.513

High

343627

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

343628

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

343648

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

185321

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

343546

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.501

High

343593

S12A1
Solute carrier family 12 member 1

1

11

High-throughput

0.501

High

164755

GDF8
Growth/differentiation factor 8

1

2

High-throughput

0.489

High

325246

OR2A4
Olfactory receptor 2A4

1

1

High-throughput

0.489

High

343577

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.489

High

343578

HXC5
Homeobox protein Hox-C5

1

2

High-throughput

0.489

High

343590

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.489

High

343613

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

343614

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

1

High-throughput

0.489

High

343631

ESPB1
Epididymal sperm-binding protein 1

1

2

High-throughput

0.489

High

343636

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.489

High

343637

KCD14
BTB/POZ domain-containing protein KCTD14

1

10

High-throughput

0.489

High

343641

DNAI2
Dynein axonemal intermediate chain 2

1

4

High-throughput

0.489

High

343642

TSN10
Tetraspanin-10

1

1

High-throughput

0.489

High

343643

KLK15
Kallikrein-15

1

7

High-throughput

0.489

High

343660

NTNG1
Netrin-G1

1

2

High-throughput

0.489

High

343664

RM42
Large ribosomal subunit protein mL42

1

1

High-throughput

0.489

High

343657

WDR3
WD repeat-containing protein 3

1

6

Small-scale

0.481

High

259265

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

343538

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

343573

S12A2
Solute carrier family 12 member 2

1

10

Small-scale

0.479

High

343580

KIF23
Kinesin-like protein KIF23

1

7

High-throughput

0.479

High

343582

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

343584

EP300
Histone acetyltransferase p300

1

10

High-throughput

0.479

High

343617

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

343625

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

158077

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

343560

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

343601

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

343649

TRM1
tRNA

1

0

High-throughput

0.458

High

343654

TRM7
tRNA

1

0

High-throughput

0.458

High

343547

HEPS
Serine protease hepsin

1

4

High-throughput

0.445

High

343550

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

343554

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

1

High-throughput

0.445

High

343574

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

7

High-throughput

0.445

High

343579

IL5RA
Interleukin-5 receptor subunit alpha

1

7

High-throughput

0.445

High

343603

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.445

High

343656

STRP2
Striatin-interacting protein 2

1

10

High-throughput

0.445

High

343553

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.437

High

343558

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.437

High

343564

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

343569

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

343588

TIF1B
Transcription intermediary factor 1-beta

1

9

High-throughput

0.437

High

330010

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.407

High

343607

PKHG7
Pleckstrin homology domain-containing family G member 7

1

10

High-throughput

0.407

High

343618

GMCL2
Germ cell-less protein-like 2

1

9

High-throughput

0.407

High

254260

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

2

0

High-throughput

0.328

High

343549

CFC1
Cryptic protein

1

0

High-throughput

0.279

Low

343585

SCRN3
Secernin-3

1

0

High-throughput

0.279

Low

343598

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.279

Low

343620

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.279

Low

343632

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.279

Low

343638

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.279

Low

343651

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.279

Low

343652

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025