Protein: ZUP1
Zinc finger-containing ubiquitin peptidase 1 (EC 3.4.19.12) (Lys-63-specific deubiquitinase ZUFSP) (DUB) (Zinc finger with UFM1-specific peptidase domain protein)

Gene: ZUP1
Organism: Homo sapiens
Interactions: 169
UniProt ID: Q96AP4

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476161

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

4

Small-scale

0.926

High

651896

RFA1
Replication protein A 70 kDa DNA-binding subunit

4

1

Small-scale

0.676

High

1069214

TCAL1
Transcription elongation factor A protein-like 1

4

0

Small-scale

0.664

High

304283

UBR5
E3 ubiquitin-protein ligase UBR5

3

2

Small-scale

0.640

High

553381

RFA2
Replication protein A 32 kDa subunit

3

1

Small-scale

0.640

High

721107

RFA3
Replication protein A 14 kDa subunit

3

2

Small-scale

0.640

High

803683

BAG6
Large proline-rich protein BAG6

1

3

Small-scale

0.618

High

924379

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

1

Small-scale

0.618

High

1268316

HMHA1
Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1

2

6

High-throughput

0.606

High

838536

MMP14
Matrix metalloproteinase-14

2

0

High-throughput

0.580

High

850140

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

0

Small-scale

0.559

High

790843

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

High-throughput

0.541

High

529527

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

153750

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.486

High

929237

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.481

High

127337

IPO5
Importin-5

1

2

Small-scale

0.479

High

163106

XPO1
Exportin-1

1

2

Small-scale

0.479

High

241794

CCD22
Coiled-coil domain-containing protein 22

1

2

High-throughput

0.479

High

359396

K1C14
Keratin, type I cytoskeletal 14

1

8

Small-scale

0.479

High

359523

K2C6A
Keratin, type II cytoskeletal 6A

1

7

Small-scale

0.479

High

380509

K2C6B
Keratin, type II cytoskeletal 6B

1

7

Small-scale

0.479

High

380664

K2C1
Keratin, type II cytoskeletal 1

1

7

Small-scale

0.479

High

381267

TBB4A
Tubulin beta-4A chain

1

3

Small-scale

0.479

High

382098

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.479

High

428353

TBB5
Tubulin beta chain

1

3

Small-scale

0.479

High

443708

VIME
Vimentin

1

6

Small-scale

0.479

High

445100

K1C16
Keratin, type I cytoskeletal 16

1

8

Small-scale

0.479

High

502408

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.479

High

504535

HSP7C
Heat shock cognate 71 kDa protein

1

3

Small-scale

0.479

High

517776

K2C3
Keratin, type II cytoskeletal 3

1

6

Small-scale

0.479

High

531407

K1C10
Keratin, type I cytoskeletal 10

1

9

Small-scale

0.479

High

531504

K1C13
Keratin, type I cytoskeletal 13

1

8

Small-scale

0.479

High

531615

K2C5
Keratin, type II cytoskeletal 5

1

6

Small-scale

0.479

High

535510

GFAP
Glial fibrillary acidic protein

1

6

Small-scale

0.479

High

542405

PLAK
Junction plakoglobin

1

3

Small-scale

0.479

High

611309

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

Small-scale

0.479

High

681553

DNJA1
DnaJ homolog subfamily A member 1

1

1

Small-scale

0.479

High

714041

HS71L
Heat shock 70 kDa protein 1-like

1

3

Small-scale

0.479

High

724120

K1C9
Keratin, type I cytoskeletal 9

1

10

Small-scale

0.479

High

729151

K22E
Keratin, type II cytoskeletal 2 epidermal

1

7

Small-scale

0.479

High

794293

MSH2
DNA mismatch repair protein Msh2

1

2

High-throughput

0.479

High

809153

UTRN
Utrophin

1

1

High-throughput

0.479

High

826028

FAS
Fatty acid synthase

1

1

Small-scale

0.479

High

831019

CTCF
Transcriptional repressor CTCF

1

4

High-throughput

0.479

High

833153

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

3

High-throughput

0.479

High

855526

MSH6
DNA mismatch repair protein Msh6

1

2

High-throughput

0.479

High

871717

HSP72
Heat shock-related 70 kDa protein 2

1

3

Small-scale

0.479

High

874557

XPO2
Exportin-2

1

9

Small-scale

0.479

High

891958

ACTB
Actin, cytoplasmic 1

1

2

Small-scale

0.479

High

897101

ACTZ
Alpha-centractin

1

3

High-throughput

0.479

High

915469

ACTA
Actin, aortic smooth muscle

1

2

Small-scale

0.479

High

970826

DSG1
Desmoglein-1

1

2

Small-scale

0.479

High

980307

K1C17
Keratin, type I cytoskeletal 17

1

8

Small-scale

0.479

High

990907

ZO1
Tight junction protein ZO-1

1

1

High-throughput

0.479

High

1029711

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.479

High

1037347

TBB3
Tubulin beta-3 chain

1

3

Small-scale

0.479

High

1046540

TBB2A
Tubulin beta-2A chain

1

3

Small-scale

0.479

High

1051635

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

Small-scale

0.479

High

1082320

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.479

High

1133453

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

Small-scale

0.479

High

1147633

FTM
Protein fantom

1

1

High-throughput

0.479

High

1154021

K2C80
Keratin, type II cytoskeletal 80

1

5

Small-scale

0.479

High

1175082

TBA1A
Tubulin alpha-1A chain

1

1

Small-scale

0.479

High

1192455

K2C1B
Keratin, type II cytoskeletal 1b

1

7

Small-scale

0.479

High

1202038

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

Small-scale

0.479

High

1205716

HOME1
Homer protein homolog 1

1

2

High-throughput

0.479

High

1231028

K2C78
Keratin, type II cytoskeletal 78

1

8

Small-scale

0.479

High

1265884

DDB2
DNA damage-binding protein 2

1

1

High-throughput

0.479

High

1271992

RAD50
DNA repair protein RAD50

1

1

High-throughput

0.479

High

1284379

DHRS4
Dehydrogenase/reductase SDR family member 4

1

2

High-throughput

0.479

High

1284383

PECR
Peroxisomal trans-2-enoyl-CoA reductase

1

2

High-throughput

0.479

High

1284386

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

Small-scale

0.479

High

1284388

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

3

High-throughput

0.479

High

1284390

TBB1
Tubulin beta-1 chain

1

4

Small-scale

0.479

High

1284392

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1

2

High-throughput

0.479

High

1284394

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

3

High-throughput

0.479

High

1284398

ZO2
Tight junction protein ZO-2

1

1

High-throughput

0.479

High

1284400

INO80
Chromatin-remodeling ATPase INO80

1

1

High-throughput

0.479

High

1261252

Q8WVC2
40S ribosomal protein S21

1

1

High-throughput

0.470

High

64549

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.458

High

237999

EXOC3
Exocyst complex component 3

1

0

High-throughput

0.458

High

254992

DEPD5
GATOR1 complex protein DEPDC5

1

0

High-throughput

0.458

High

274370

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

0

High-throughput

0.458

High

345126

CYTA
Cystatin-A

1

0

Small-scale

0.458

High

351765

SOMA
Somatotropin

1

0

Small-scale

0.458

High

373410

CATA
Catalase

1

0

Small-scale

0.458

High

396273

ARGI1
Arginase-1

1

0

Small-scale

0.458

High

427636

ANXA2
Annexin A2

1

0

Small-scale

0.458

High

474579

CTF8
Chromosome transmission fidelity protein 8 homolog

1

0

High-throughput

0.458

High

598509

NF1
Neurofibromin

1

0

High-throughput

0.458

High

620405

GATA2
Endothelial transcription factor GATA-2

1

0

High-throughput

0.458

High

637507

PSA1
Proteasome subunit alpha type-1

1

0

Small-scale

0.458

High

653335

PYR1
Multifunctional protein CAD

1

0

Small-scale

0.458

High

676958

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.458

High

683123

CASPE
Caspase-14

1

0

Small-scale

0.458

High

726530

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.458

High

787539

MTOR
Serine/threonine-protein kinase mTOR

1

0

High-throughput

0.458

High

789322

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.458

High

853025

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

Small-scale

0.458

High

867628

BLM
RecQ-like DNA helicase BLM

1

0

High-throughput

0.458

High

880351

DPOE2
DNA polymerase epsilon subunit 2

1

0

High-throughput

0.458

High

892871

IF4A1
Eukaryotic initiation factor 4A-I

1

0

Small-scale

0.458

High

942224

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

943397

TCPB
T-complex protein 1 subunit beta

1

0

Small-scale

0.458

High

946586

DCD
Dermcidin

1

0

Small-scale

0.458

High

958990

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

992296

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.458

High

1046243

BLMH
Bleomycin hydrolase

1

0

Small-scale

0.458

High

1059783

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1137545

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.458

High

1137634

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.458

High

1159225

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

Small-scale

0.458

High

1160263

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.458

High

1161593

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1163784

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1192161

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.458

High

1205943

C2CD5
C2 domain-containing protein 5

1

0

High-throughput

0.458

High

1230503

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.458

High

1230691

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

0

High-throughput

0.458

High

1261207

CTF18
Chromosome transmission fidelity protein 18 homolog

1

0

High-throughput

0.458

High

1284378

FNBP1
Formin-binding protein 1

1

0

High-throughput

0.458

High

1284380

DCC1
Sister chromatid cohesion protein DCC1

1

0

High-throughput

0.458

High

1284381

LST8
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.458

High

1284384

HELZ2
3'-5' exoribonuclease HELZ2

1

0

High-throughput

0.458

High

1284385

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

0

High-throughput

0.458

High

1284391

DPOE4
DNA polymerase epsilon subunit 4

1

0

High-throughput

0.458

High

1284393

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.458

High

1284399

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.458

High

1284401

TIM
Protein timeless homolog

1

0

High-throughput

0.458

High

1284402

CBPC1
Cytosolic carboxypeptidase 1

1

0

High-throughput

0.458

High

246474

DTNB
Dystrobrevin beta

1

1

High-throughput

0.437

High

993993

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

Small-scale

0.437

High

996000

DSC1
Desmocollin-1

1

3

Small-scale

0.437

High

1121537

EIPR1
EARP and GARP complex-interacting protein 1

1

1

High-throughput

0.437

High

1125337

FILA2
Filaggrin-2

1

5

Small-scale

0.437

High

1168108

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

3

High-throughput

0.437

High

1206179

HORN
Hornerin

1

5

Small-scale

0.437

High

1255057

DMXL2
DmX-like protein 2

1

1

High-throughput

0.437

High

1284373

VPS39
Vam6/Vps39-like protein

1

3

High-throughput

0.437

High

1284374

IFT74
Intraflagellar transport protein 74 homolog

1

2

High-throughput

0.437

High

1243288

SHCBP
SHC SH2 domain-binding protein 1

1

0

High-throughput

0.282

High

1284397

CLN8
Protein CLN8

1

0

Small-scale

0.251

Low

161230

VP26C
Vacuolar protein sorting-associated protein 26C

1

0

High-throughput

0.249

Low

203309

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.249

Low

300496

FRYL
Protein furry homolog-like

1

0

High-throughput

0.249

Low

363870

ALBU
Albumin

1

0

Small-scale

0.249

Low

551801

DESP
Desmoplakin

1

0

Small-scale

0.249

Low

794070

MATR3
Matrin-3

1

0

Small-scale

0.249

Low

873464

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.249

Low

981357

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

Small-scale

0.249

Low

1101519

KIF7
Kinesin-like protein KIF7

1

0

High-throughput

0.249

Low

1122601

CCD93
Coiled-coil domain-containing protein 93

1

0

High-throughput

0.249

Low

1132334

SZT2
KICSTOR complex protein SZT2

1

0

High-throughput

0.249

Low

1132666

FKB15
FK506-binding protein 15

1

0

High-throughput

0.249

Low

1134390

KPRP
Keratinocyte proline-rich protein

1

0

Small-scale

0.249

Low

1203415

IT70A
Intraflagellar transport protein 70A

1

0

High-throughput

0.249

Low

1224765

ASPM
Abnormal spindle-like microcephaly-associated protein

1

0

Small-scale

0.249

Low

1284371

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

1284372

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.249

Low

1284375

KICS2
KICSTOR subunit 2

1

0

High-throughput

0.249

Low

1284376

SPB12
Serpin B12

1

0

Small-scale

0.249

Low

1284377

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.249

Low

1284382

AFG2B
ATPase family gene 2 protein homolog B

1

0

High-throughput

0.249

Low

1284387

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.249

Low

1284389

CPVL
Probable serine carboxypeptidase CPVL

1

0

Small-scale

0.249

Low

1284395

RELCH
RAB11-binding protein RELCH

1

0

Small-scale

0.249

Low

1284396

IFT80
Intraflagellar transport protein 80 homolog

1

0

High-throughput

0.249

Low

1284403

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

0

High-throughput

0.249

Low

1284404

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024