Protein: STK25
Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1)

Gene: STK25
Organism: Homo sapiens
Interactions: 111
UniProt ID: O00506

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

138868

PDC10
Programmed cell death protein 10

16

5

Small-scale

0.990

High

138898

STK24
Serine/threonine-protein kinase 24

10

16

High-throughput

0.975

High

138883

STK26
Serine/threonine-protein kinase 26

8

15

High-throughput

0.970

High

138842

TAOK1
Serine/threonine-protein kinase TAO1

6

16

High-throughput

0.949

High

138830

SLMAP
Sarcolemmal membrane-associated protein

5

20

High-throughput

0.925

High

138887

TAOK2
Serine/threonine-protein kinase TAO2

5

18

High-throughput

0.925

High

138894

CAB39
Calcium-binding protein 39

5

7

Small-scale

0.919

High

138809

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

4

14

High-throughput

0.909

High

138810

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

3

14

High-throughput

0.871

High

138859

CTTB2
Cortactin-binding protein 2

3

20

High-throughput

0.855

High

138803

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.789

High

138825

GOGA2
Golgin subfamily A member 2

13

20

Small-scale

0.763

High

138795

STRN
Striatin

8

20

High-throughput

0.753

High

138827

STRN3
Striatin-3

8

20

High-throughput

0.753

High

138884

CT2NL
CTTNBP2 N-terminal-like protein

8

20

High-throughput

0.753

High

138836

STRP1
Striatin-interacting protein 1

7

12

High-throughput

0.749

High

138876

STRN4
Striatin-4

5

20

High-throughput

0.720

High

138895

PHOCN
MOB-like protein phocein

5

18

High-throughput

0.716

High

138792

STK25
Serine/threonine-protein kinase 25

2

15

Small-scale

0.712

High

138847

ZDH17
Palmitoyltransferase ZDHHC17

1

14

High-throughput

0.698

High

138888

STRP2
Striatin-interacting protein 2

4

12

High-throughput

0.697

High

138897

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

15

High-throughput

0.692

High

138802

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

138872

TAOK3
Serine/threonine-protein kinase TAO3

1

16

High-throughput

0.691

High

138877

LATS2
Serine/threonine-protein kinase LATS2

1

18

High-throughput

0.691

High

138878

UBQL4
Ubiquilin-4

1

5

High-throughput

0.691

High

138866

SIKE1
Suppressor of IKBKE 1

4

13

High-throughput

0.691

High

138824

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

3

20

High-throughput

0.675

High

138796

KI20A
Kinesin-like protein KIF20A

3

16

High-throughput

0.667

High

138865

GORS1
Golgi reassembly-stacking protein 1

3

1

High-throughput

0.667

High

138889

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

3

5

High-throughput

0.667

High

138896

HBS1L
HBS1-like protein

3

3

High-throughput

0.667

High

138880

FGOP2
FGFR1 oncogene partner 2

5

13

High-throughput

0.657

High

138797

CCDB1
Cyclin-D1-binding protein 1

3

1

High-throughput

0.654

High

138834

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

12

Small-scale

0.647

High

138804

TRI27
Zinc finger protein RFP

2

9

High-throughput

0.646

High

138846

PRSR2
Proline and serine-rich protein 2

4

2

High-throughput

0.636

High

138813

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

4

High-throughput

0.618

High

138800

MOS
Proto-oncogene serine/threonine-protein kinase mos

1

5

High-throughput

0.618

High

138874

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

138891

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

16

High-throughput

0.618

High

138833

AR13B
ADP-ribosylation factor-like protein 13B

3

11

High-throughput

0.609

High

138844

ZN598
E3 ubiquitin-protein ligase ZNF598

3

9

High-throughput

0.609

High

138849

PGKA1
PDCD10 and GCKIII kinases-associated protein 1

3

2

High-throughput

0.609

High

138799

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

17

High-throughput

0.575

High

138851

FXL14
F-box/LRR-repeat protein 14

1

4

High-throughput

0.575

High

138886

TNIK
TRAF2 and NCK-interacting protein kinase

1

18

High-throughput

0.575

High

138812

PBX2
Pre-B-cell leukemia transcription factor 2

2

1

High-throughput

0.574

High

138899

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.561

High

64980

GG6L9
Golgin subfamily A member 6-like protein 9

2

17

High-throughput

0.553

High

138817

EVA1C
Protein eva-1 homolog C

2

1

High-throughput

0.549

High

138793

ACACB
Acetyl-CoA carboxylase 2

1

13

High-throughput

0.536

High

138807

TCPA
T-complex protein 1 subunit alpha

1

17

High-throughput

0.536

High

138815

CLCN7
H(+)/Cl(-) exchange transporter 7

1

1

High-throughput

0.536

High

138818

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

1

High-throughput

0.536

High

138819

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

20

High-throughput

0.536

High

138821

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

20

High-throughput

0.536

High

138823

DYL1
Dynein light chain 1, cytoplasmic

1

13

High-throughput

0.536

High

138828

ACACA
Acetyl-CoA carboxylase 1

1

13

High-throughput

0.536

High

138829

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.536

High

138831

ANGP1
Angiopoietin-1

1

8

High-throughput

0.536

High

138839

RIPR1
Rho family-interacting cell polarization regulator 1

1

6

High-throughput

0.536

High

138848

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

138854

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.536

High

138855

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

1

High-throughput

0.536

High

138864

AKAP9
A-kinase anchor protein 9

1

20

High-throughput

0.536

High

138873

CPVL
Probable serine carboxypeptidase CPVL

1

2

High-throughput

0.536

High

138875

TRI45
E3 ubiquitin-protein ligase TRIM45

1

20

High-throughput

0.536

High

138879

LIN7C
Protein lin-7 homolog C

1

14

High-throughput

0.536

High

138882

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

4

High-throughput

0.536

High

138853

FXL16
F-box/LRR-repeat protein 16

1

4

High-throughput

0.514

High

138835

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

138837

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.513

High

138820

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

3

High-throughput

0.508

High

138794

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

11

High-throughput

0.501

High

138801

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.501

High

138814

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

18

High-throughput

0.501

High

138806

KCNA6
Potassium voltage-gated channel subfamily A member 6

1

2

High-throughput

0.489

High

138840

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.489

High

138843

MILR1
Allergin-1

1

7

High-throughput

0.489

High

138893

SGT1
Protein SGT1 homolog

1

12

High-throughput

0.489

High

138808

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

3

High-throughput

0.479

High

138811

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

138832

CL16A
Protein CLEC16A

1

4

High-throughput

0.479

High

138838

RICTR
Rapamycin-insensitive companion of mTOR

1

4

High-throughput

0.479

High

138841

ACD11
Acyl-CoA dehydrogenase family member 11

1

4

High-throughput

0.479

High

138845

TAXB1
Tax1-binding protein 1

1

20

High-throughput

0.479

High

138856

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

138860

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

138863

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

138867

CCM2
Cerebral cavernous malformations 2 protein

1

1

Small-scale

0.479

High

138869

TOLIP
Toll-interacting protein

1

2

High-throughput

0.479

High

138881

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

1

High-throughput

0.479

High

138885

XPO7
Exportin-7

1

12

High-throughput

0.479

High

138871

ARV1
Protein ARV1

1

0

High-throughput

0.458

High

138822

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.445

High

138826

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

9

Small-scale

0.445

High

138852

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

3

High-throughput

0.445

High

138858

WDR48
WD repeat-containing protein 48

1

13

High-throughput

0.445

High

104814

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

138805

TIMP2
Metalloproteinase inhibitor 2

1

2

High-throughput

0.437

High

138798

CBX6
Chromobox protein homolog 6

1

4

High-throughput

0.407

High

138890

T3JAM
TRAF3-interacting JNK-activating modulator

1

20

High-throughput

0.407

High

138850

IHO1
Interactor of HORMAD1 protein 1

1

0

High-throughput

0.299

High

138857

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.299

High

138816

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.279

Low

138861

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.279

Low

138862

KBP
KIF-binding protein

1

0

High-throughput

0.279

Low

138892

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.279

Low

138870

TLRN1
Talin rod domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025