HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: GRWD1 (Q9BQ67)
Glutamate-rich WD repeat-containing protein 1
Gene: GRWD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34933446
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 446
+	Hs
		152622 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		152663 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		WDR5B_HUMAN (348-445): 9.02e-15: 76.9: 16.33
+	Hs
		903444 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		203735 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		DAW1_HUMAN (135-445): 2.87e-69: 227: 15.82
+	Mm
		1141954 EHMT2_MOUSE (4917-5533): 2.26e-101: 361: 18.29		RBBP4_MOUSE (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		997734 ITSN1_HUMAN (3410-4271): 7.27e-97: 353: 13.54		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Mm
		1141960 Q6AXH7_MOUSE (5194-5519): 2.35e-94: 327: 19.48		RBBP7_MOUSE (66-247): 3.22e-20: 94.3: 10.42
+	Mm
		1141935 Q6AXH7_MOUSE (5194-5519): 2.35e-94: 327: 19.48		RBBP4_MOUSE (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		1083337 EZH1_HUMAN (5124-5519): 8.8e-93: 322: 16.90		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Mm
		1141957 EZH2_MOUSE (5194-5519): 1.01e-92: 322: 19.48		RBBP7_MOUSE (66-247): 3.22e-20: 94.3: 10.42
+	Mm
		936647 EZH1_MOUSE (5186-5519): 1.6e-92: 322: 18.49		RBBP7_MOUSE (66-247): 3.22e-20: 94.3: 10.42
+	Mm
		1141929 EZH2_MOUSE (5194-5519): 1.01e-92: 322: 19.48		RBBP4_MOUSE (62-247): 7.65e-20: 93.1: 10.71
+	Mm
		936646 EZH1_MOUSE (5186-5519): 1.6e-92: 322: 18.49		RBBP4_MOUSE (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		997839 EZH1_HUMAN (5124-5519): 8.8e-93: 322: 16.90		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		1079986 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Hs
		997735 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Dm
		785628 EZ_DROME (5224-5516): 2.4e-89: 313: 18.75		CAF1_DROME (62-247): 5.03e-21: 96.6: 10.71
+	Hs
		203695 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Hs
		203672 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	At
		186920 MEDEA_ARATH (5122-5520): 1.15e-93: 323: 15.67		MSI1_ARATH (307-445): 6.04e-14: 75.4: 16.89