Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.917

The method score is based on:

Property Details
Experiments 15070904, 11046132, 11533036, 19446522, 34189428
Identification Methods pull down, far western blotting, nuclear magnetic resonance, blue native page
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EBP50_C~PDZ, PDZ~PDZ
Common GO terms GO:0001726 - ruffle
GO:0002009 - morphogenesis of an epithelium
GO:0003096 - renal sodium ion transport
GO:0005102 - signaling receptor binding
GO:0005737 - cytoplasm
and 70 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 358
Hs

1 358
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+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Rn
+ Mm
+ Rn
+ Rn
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024