Protein: MKRN1
E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1)

Gene: MKRN1
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q9UHC7

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0003723 - RNA binding
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1459796

MKRN1
E3 ubiquitin-protein ligase makorin-1

2

7

Small-scale

0.799

High

906815

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

14

High-throughput

0.783

High

931612

RD23A
UV excision repair protein RAD23 homolog A

2

2

High-throughput

0.783

High

931718

RD23B
UV excision repair protein RAD23 homolog B

2

2

High-throughput

0.783

High

1459810

UB2D4
Ubiquitin-conjugating enzyme E2 D4

2

14

High-throughput

0.783

High

1429243

MKRN2
E3 ubiquitin-protein ligase makorin-2

2

8

High-throughput

0.754

High

1009360

PRR3
Proline-rich protein 3

1

3

High-throughput

0.691

High

550506

PABP1
Polyadenylate-binding protein 1

3

10

Small-scale

0.670

High

957229

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

14

High-throughput

0.656

High

1383943

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

15

High-throughput

0.656

High

1102126

PABP4
Polyadenylate-binding protein 4

3

10

Small-scale

0.656

High

414787

P53
Cellular tumor antigen p53

2

1

Small-scale

0.641

High

473160

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

19

High-throughput

0.628

High

1211524

CELF3
CUGBP Elav-like family member 3

2

17

High-throughput

0.628

High

1453458

NOP53
Ribosome biogenesis protein NOP53

2

2

High-throughput

0.628

High

508784

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

Small-scale

0.618

High

1093735

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

8

High-throughput

0.618

High

1420984

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

14

High-throughput

0.618

High

135377

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

2

16

Small-scale

0.611

High

994855

YBOX1
Y-box-binding protein 1

2

10

Small-scale

0.611

High

1111892

TRA2A
Transformer-2 protein homolog alpha

2

13

High-throughput

0.611

High

1140048

RRS1
Ribosome biogenesis regulatory protein homolog

2

1

High-throughput

0.611

High

1459811

LC7L2
Putative RNA-binding protein Luc7-like 2

2

2

High-throughput

0.611

High

1446682

LUC7L
Putative RNA-binding protein Luc7-like 1

3

2

High-throughput

0.609

High

943826

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

2

High-throughput

0.606

High

1028722

U2AF1
Splicing factor U2AF 35 kDa subunit

1

0

Small-scale

0.586

High

808189

CDN1A
Cyclin-dependent kinase inhibitor 1

2

0

Small-scale

0.585

High

1346973

SNIP1
Smad nuclear-interacting protein 1

2

0

High-throughput

0.585

High

810446

RL3
Large ribosomal subunit protein uL3

2

1

Small-scale

0.584

High

1152669

ELAV1
ELAV-like protein 1

2

11

Small-scale

0.584

High

1245760

LARP1
La-related protein 1

2

9

Small-scale

0.584

High

1453305

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

2

10

Small-scale

0.584

High

140474

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

833696

NAA10
N-alpha-acetyltransferase 10

2

0

High-throughput

0.580

High

1119023

BYST
Bystin

2

0

High-throughput

0.580

High

1185335

F161A
Protein FAM161A

2

0

High-throughput

0.580

High

1218688

OTU1
Ubiquitin thioesterase OTU1

2

0

High-throughput

0.580

High

1459001

DAXX
Death domain-associated protein 6

2

0

High-throughput

0.580

High

397157

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

668744

APC
Adenomatous polyposis coli protein

1

4

Small-scale

0.561

High

842882

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

3

Small-scale

0.561

High

1096937

FADD
FAS-associated death domain protein

1

1

Small-scale

0.561

High

162976

TERT
Telomerase reverse transcriptase

2

0

Small-scale

0.559

High

1458467

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

4

High-throughput

0.541

High

861004

RS10
Small ribosomal subunit protein eS10

1

2

Small-scale

0.536

High

192657

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

256699

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

12

High-throughput

0.536

High

301252

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.536

High

462693

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

16

High-throughput

0.536

High

1016663

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.536

High

1148820

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

18

High-throughput

0.536

High

1168915

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

4

High-throughput

0.536

High

1252543

LN28B
Protein lin-28 homolog B

1

10

High-throughput

0.536

High

1314850

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

4

High-throughput

0.536

High

1387908

PABP5
Polyadenylate-binding protein 5

1

10

High-throughput

0.536

High

1429470

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

3

High-throughput

0.536

High

1451152

RFOX1
RNA binding protein fox-1 homolog 1

1

15

High-throughput

0.536

High

1453111

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

High-throughput

0.536

High

1459797

PURG
Purine-rich element-binding protein gamma

1

2

High-throughput

0.536

High

1459799

ZN346
Zinc finger protein 346

1

3

High-throughput

0.536

High

1459808

YBOX2
Y-box-binding protein 2

1

10

High-throughput

0.536

High

890906

TSC2
Tuberin

1

0

High-throughput

0.518

High

156366

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.513

High

584877

NQO1
NAD(P)H dehydrogenase [quinone] 1

1

0

High-throughput

0.513

High

1316801

SELH
Selenoprotein H

1

0

High-throughput

0.513

High

332271

KCNH1
Voltage-gated delayed rectifier potassium channel KCNH1

1

2

Small-scale

0.512

High

1415395

DUS23
Dual specificity protein phosphatase 23

1

2

High-throughput

0.508

High

1428406

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.508

High

1459800

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

2

High-throughput

0.489

High

1384045

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.486

High

1439395

KC1G1
Casein kinase I isoform gamma-1

1

0

High-throughput

0.486

High

250880

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

15

Small-scale

0.479

High

460654

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

542685

TOP2A
DNA topoisomerase 2-alpha

1

2

High-throughput

0.479

High

576844

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

581600

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

4

Small-scale

0.479

High

586939

RS2
Small ribosomal subunit protein uS5

1

1

Small-scale

0.479

High

599898

YBOX3
Y-box-binding protein 3

1

10

Small-scale

0.479

High

615451

SON
Protein SON

1

1

High-throughput

0.479

High

616038

RL17
Large ribosomal subunit protein uL22

1

1

Small-scale

0.479

High

624169

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

4

Small-scale

0.479

High

655368

SFPQ
Splicing factor, proline- and glutamine-rich

1

13

High-throughput

0.479

High

685759

U2AF2
Splicing factor U2AF 65 kDa subunit

1

13

Small-scale

0.479

High

789588

PPARG
Peroxisome proliferator-activated receptor gamma

1

5

Small-scale

0.479

High

834553

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

842589

RL35
Large ribosomal subunit protein uL29

1

1

Small-scale

0.479

High

854370

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.479

High

860397

RS9
Small ribosomal subunit protein uS4

1

1

Small-scale

0.479

High

868274

SYQ
Glutamine--tRNA ligase

1

2

High-throughput

0.479

High

910721

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

8

Small-scale

0.479

High

960289

RL26
Large ribosomal subunit protein uL24

1

2

Small-scale

0.479

High

969508

RS8
Small ribosomal subunit protein eS8

1

1

Small-scale

0.479

High

973620

RS11
Small ribosomal subunit protein uS17

1

2

Small-scale

0.479

High

977404

RS4X
Small ribosomal subunit protein eS4, X isoform

1

2

Small-scale

0.479

High

978777

RL23A
Large ribosomal subunit protein uL23

1

2

Small-scale

0.479

High

985053

RL31
Large ribosomal subunit protein eL31

1

1

Small-scale

0.479

High

1025766

PURA
Transcriptional activator protein Pur-alpha

1

2

Small-scale

0.479

High

1027827

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

Small-scale

0.479

High

1029048

TIAR
Nucleolysin TIAR

1

8

Small-scale

0.479

High

1059989

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

4

High-throughput

0.479

High

1089912

ILF3
Interleukin enhancer-binding factor 3

1

4

Small-scale

0.479

High

1120377

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

15

Small-scale

0.479

High

1125251

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

7

Small-scale

0.479

High

1129529

PUM1
Pumilio homolog 1

1

3

Small-scale

0.479

High

1130211

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.479

High

1130504

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.479

High

1139696

SYK
Lysine--tRNA ligase

1

1

High-throughput

0.479

High

1148184

PUM3
Pumilio homolog 3

1

3

High-throughput

0.479

High

1233965

Q6ICH2
single-stranded DNA cytosine deaminase

1

7

High-throughput

0.479

High

1271598

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.479

High

1280576

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1351498

BRX1
Ribosome biogenesis protein BRX1 homolog

1

2

High-throughput

0.479

High

1359615

ATX2L
Ataxin-2-like protein

1

5

Small-scale

0.479

High

1365694

LAR4B
La-related protein 4B

1

8

Small-scale

0.479

High

1367516

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1370149

RENT1
Regulator of nonsense transcripts 1

1

5

Small-scale

0.479

High

1402793

STRBP
Spermatid perinuclear RNA-binding protein

1

6

Small-scale

0.479

High

1404479

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.479

High

1406515

ATX2
Ataxin-2

1

5

Small-scale

0.479

High

1418164

RM13
Large ribosomal subunit protein uL13m

1

1

High-throughput

0.479

High

1428575

DDX24
ATP-dependent RNA helicase DDX24

1

2

High-throughput

0.479

High

1438883

MOV10
Helicase MOV-10

1

5

Small-scale

0.479

High

1449868

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

7

Small-scale

0.479

High

1454634

SYLC
Leucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

1459798

AGO2
Protein argonaute-2

1

3

Small-scale

0.479

High

1459801

FZR1
Fizzy-related protein homolog

1

5

High-throughput

0.479

High

1459802

PRP19
Pre-mRNA-processing factor 19

1

4

High-throughput

0.479

High

1459803

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

3

Small-scale

0.479

High

1459805

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

1

Small-scale

0.479

High

1459806

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

1459809

TR150
Thyroid hormone receptor-associated protein 3

1

8

High-throughput

0.479

High

1459813

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

13

Small-scale

0.479

High

139631

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

181189

AXIN1
Axin-1

1

0

Small-scale

0.458

High

229098

AKAP8
A-kinase anchor protein 8

1

0

Small-scale

0.458

High

286101

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.458

High

694052

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.458

High

859493

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

926555

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

933751

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.458

High

935250

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

973340

RS13
Small ribosomal subunit protein uS15

1

0

Small-scale

0.458

High

983223

RS26
Small ribosomal subunit protein eS26

1

0

Small-scale

0.458

High

1089361

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

0

High-throughput

0.458

High

1119913

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.458

High

1198686

NCBP3
Nuclear cap-binding protein subunit 3

1

0

Small-scale

0.458

High

1241834

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1277960

NUFP2
FMR1-interacting protein NUFIP2

1

0

Small-scale

0.458

High

1332247

KRI1
Protein KRI1 homolog

1

0

High-throughput

0.458

High

1429637

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

1435618

RPF2
Ribosome production factor 2 homolog

1

0

High-throughput

0.458

High

1459807

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.458

High

1459812

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.458

High

73470

B2CML4
single-stranded DNA cytosine deaminase

1

7

High-throughput

0.445

High

106800

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

298112

SPF27
Pre-mRNA-splicing factor SPF27

1

1

High-throughput

0.437

High

373419

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.437

High

406770

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.437

High

1129775

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

High-throughput

0.437

High

1359717

PHIP
PH-interacting protein

1

3

High-throughput

0.437

High

1325123

MTURN
Maturin

2

0

High-throughput

0.316

High

1387346

OTUB2
Ubiquitin thioesterase OTUB2

2

0

High-throughput

0.316

High

1403987

SCN2A
Sodium channel protein type 2 subunit alpha

1

0

High-throughput

0.279

Low

1420295

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

65827

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.249

Low

243760

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

0

High-throughput

0.249

Low

1459804

TUTLB
Protein turtle homolog B

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025