HitPredict

Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	11046132
Identification Methods	far western blotting, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005902 - microvillus GO:0016020 - membrane GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Hs			1 1089
+	Hs
		153861 NHRF1_HUMAN (1-358): 2.51e-82: 256: 100.00		PGFRB_HUMAN (29-1089): 0: 650: 43.33
+	Hs
		452428 NHRF2_HUMAN (5-358): 2.98e-67: 216: 49.44		PGFRB_HUMAN (29-1089): 0: 650: 43.33
+	Hs
		452421 SNTB1_HUMAN (5-347): 5.96e-41: 152: 16.07		PGFRB_HUMAN (29-1089): 0: 650: 43.33
+	Hs
		280015 MPDZ_HUMAN (1-187): 6.93e-14: 75.1: 22.45		KIT_HUMAN (18-978): 0: 559: 33.64
+	Hs
		609282 SNTB1_HUMAN (5-347): 5.96e-41: 152: 16.07		FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74
+	Hs
		280018 MPDZ_HUMAN (1-187): 6.93e-14: 75.1: 22.45		FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74
+	Hs
		153881 NHRF1_HUMAN (1-358): 2.51e-82: 256: 100.00		UFO_HUMAN (13-225): 2.38e-15: 83.4: 14.71
+	Hs
		153863 NHRF1_HUMAN (1-358): 2.51e-82: 256: 100.00		FGFR1_HUMAN (3-177): 1.39e-14: 80.7: 10.71
+	Mm
		404019 NHRF2_MOUSE (5-358): 6.2e-68: 218: 48.59		PGFRB_MOUSE (4-571): 7.37e-24: 111: 11.66
+	Mm
		546303 DLG4_MOUSE (88-235): 4.07e-14: 75.5: 19.36		NTRK2_MOUSE (53-776): 3.36e-53: 202: 13.62
+	Hs
		942352 DLG4_HUMAN (88-235): 4.14e-14: 75.5: 19.36		NTRK2_HUMAN (48-776): 2.93e-51: 197: 14.04
+	Hs
		607963 SNTB1_HUMAN (5-347): 5.96e-41: 152: 16.07		FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36
+	Hs
		729276 SNTB1_HUMAN (5-347): 5.96e-41: 152: 16.07		VGFR3_HUMAN (128-609): 7.49e-19: 94.9: 11.28
+	Hs
		507990 SNTB1_HUMAN (5-347): 5.96e-41: 152: 16.07		FGFR1_HUMAN (3-177): 1.39e-14: 80.7: 10.71
+	Hs
		607966 SCRIB_HUMAN (7-337): 1.45e-29: 122: 19.83		FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36
+	Hs
		674422 SCRIB_HUMAN (7-337): 1.45e-29: 122: 19.83		UFO_HUMAN (13-225): 2.38e-15: 83.4: 14.71
+	Hs
		507995 SCRIB_HUMAN (7-337): 1.45e-29: 122: 19.83		FGFR1_HUMAN (3-177): 1.39e-14: 80.7: 10.71
+	Hs
		1049964 SCRIB_HUMAN (7-337): 1.45e-29: 122: 19.83		NTRK3_HUMAN (28-227): 3.23e-13: 76.1: 9.01
+	Hs
		169176 SCRIB_HUMAN (7-337): 1.45e-29: 122: 19.83		MUSK_HUMAN (2-127): 4.82e-12: 72.6: 12.98
+	Hs
		674412 DLG1_HUMAN (55-238): 9.08e-13: 71.6: 18.85		UFO_HUMAN (13-225): 2.38e-15: 83.4: 14.71