Interactor 1: CHK1 (O14757)
Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
Gene: CHEK1

Interactor 2: CHK1 (O14757)
Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
Gene: CHEK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.865

The method score is based on:

Property Details
Experiments 22184239, 20639859, 23068608
Identification Methods affinity chromatography technology, pull down, protein kinase assay
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000077 - DNA damage checkpoint signaling
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000785 - chromatin
GO:0000794 - condensed nuclear chromosome
GO:0001833 - inner cell mass cell proliferation
and 39 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 476
Hs

1 476
+ At
+ Zm
+ At
+ Rn
+ At
+ Zm
+ At
+ At
+ Gm
+ At
+ At
+ At
+ Dm
+ At
+ At
+ At
+ At

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Last updated: 15 Jul 2024