HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: LMTK1 (Q6ZMQ8)
Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)
Gene: AATK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0016020 - membrane GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Hs			1 1374
+	Hs
		960298 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		LMTK1_HUMAN (1-1374): 0: 976: 100.00
+	Hs
		960307 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		LMTK2_HUMAN (9-1366): 0: 690: 29.74
+	Hs
		609180 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		FGFR3_HUMAN (29-448): 5.82e-123: 403: 23.42
+	Hs
		507863 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		FGFR1_HUMAN (28-460): 6.26e-120: 396: 21.00
+	Hs
		414738 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		FGFR3_HUMAN (29-448): 5.82e-123: 403: 23.42
+	Hs
		414702 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		FGFR1_HUMAN (28-460): 6.26e-120: 396: 21.00
+	Hs
		414934 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		NTRK3_HUMAN (24-398): 5.5e-110: 369: 25.54
+	Hs
		433583 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		LYN_HUMAN (109-410): 9.62e-106: 347: 24.75
+	Hs
		411675 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		LCK_HUMAN (98-410): 1.51e-107: 352: 24.20
+	Hs
		411546 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		LCK_HUMAN (98-410): 1.51e-107: 352: 24.20
+	Hs
		414685 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		LYN_HUMAN (109-410): 9.62e-106: 347: 24.75
+	Hs
		411938 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		FYN_HUMAN (104-408): 1.36e-104: 344: 30.07
+	Hs
		411301 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		INSR_HUMAN (111-395): 4.12e-41: 167: 36.27
+	Hs
		435611 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		IGF1R_HUMAN (119-391): 2.65e-38: 159: 34.51
+	Hs
		414687 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		IGF1R_HUMAN (119-391): 2.65e-38: 159: 34.51
+	Hs
		384287 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		NTRK1_HUMAN (120-398): 5.02e-34: 143: 32.77
+	Hs
		384094 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		NTRK1_HUMAN (120-398): 5.02e-34: 143: 32.77
+	Hs
		414781 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		RYK_HUMAN (96-403): 1.66e-31: 134: 30.56
+	Hs
		384655 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		NTRK1_HUMAN (120-398): 5.02e-34: 143: 32.77
+	Hs
		337309 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		ABL1_HUMAN (588-1118): 4.91e-10: 66.4: 13.32