HitPredict

Interactor 1: MEIS2 (O14770)
Homeobox protein Meis2 (Meis1-related protein 1)
Gene: MEIS2

Interactor 2: LMX1B (O60663)
LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B)
Gene: LMX1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 477 Hs			1 402
+	Hs
		129961 MEIS1_HUMAN (1-382): 4.49e-97: 299: 83.51		LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00
+	Hs
		238116 PKNX2_HUMAN (14-417): 1.74e-52: 185: 33.86		LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00
+	Hs
		238100 PBX1_HUMAN (196-462): 3.75e-48: 173: 20.44		LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00
+	Hs
		238101 PBX2_HUMAN (277-412): 3.48e-36: 140: 31.45		LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00
+	Hs
		1255789 LMX1A_HUMAN (98-426): 1.1e-51: 181: 12.46		LMX1A_HUMAN (24-402): 5.5e-86: 268: 62.60
+	Hs
		238102 PBX3_HUMAN (277-396): 7.83e-29: 119: 30.15		LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00
+	Hs
		899927 LMX1A_HUMAN (98-426): 1.1e-51: 181: 12.46		ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61
+	Hs
		1251444 MEIS3_HUMAN (1-393): 7.66e-88: 275: 63.50		LMO3_HUMAN (53-171): 8.74e-26: 103: 40.32
+	Mm
		839895 LHX3_MOUSE (115-462): 2.68e-45: 164: 13.03		ISL1_MOUSE (49-389): 3.38e-62: 205: 28.61
+	Hs
		238099 LMX1B_HUMAN (76-432): 1.8e-53: 186: 13.89		RBTN1_HUMAN (56-171): 2.5e-48: 163: 40.50
+	Ce
		447572 UNC62_CAEEL (200-412): 1.02e-31: 129: 35.40		MEC3_CAEEL (47-291): 1.81e-55: 187: 25.73
+	Dm
		773239 EXD_DROME (277-409): 2.61e-32: 128: 30.37		Q9VJ37_DROME (49-388): 2.14e-50: 179: 23.90
+	Hs
		238113 LMX1B_HUMAN (76-432): 1.8e-53: 186: 13.89		LMO3_HUMAN (53-171): 8.74e-26: 103: 40.32
+	Hs
		1255791 LMX1A_HUMAN (98-426): 1.1e-51: 181: 12.46		LHX3_HUMAN (1-109): 1.24e-20: 94.6: 18.58
+	Hs
		238115 LMX1B_HUMAN (76-432): 1.8e-53: 186: 13.89		ISL2_HUMAN (9-108): 1.16e-14: 76.5: 20.19
+	Hs
		238123 LMX1B_HUMAN (76-432): 1.8e-53: 186: 13.89		LHX6_HUMAN (8-110): 1.83e-14: 76.1: 16.98
+	Hs
		822689 LHX1_HUMAN (107-469): 1.35e-45: 165: 16.06		LHX3_HUMAN (1-109): 1.24e-20: 94.6: 18.58
+	Hs
		822660 LHX1_HUMAN (107-469): 1.35e-45: 165: 16.06		ISL2_HUMAN (9-108): 1.16e-14: 76.5: 20.19
+	Ce
		589698 UNC62_CAEEL (200-412): 1.02e-31: 129: 35.40		LIN11_CAEEL (1-114): 5.74e-16: 80.8: 16.95