Protein: CLD4
Claudin-4 (Clostridium perfringens enterotoxin receptor) (CPE-R) (CPE-receptor) (Williams-Beuren syndrome chromosomal region 8 protein)

Gene: CLD4, CLDN4
Organism: Homo sapiens
Interactions: 71
UniProt ID: O14493

Gene Ontology (top 5):
GO:0004888 - transmembrane signaling receptor activity
GO:0005198 - structural molecule activity
GO:0005254 - chloride channel activity
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154469

MUC18
Cell surface glycoprotein MUC18

1

1

Small-scale

0.618

High

154449

FFAR2
Free fatty acid receptor 2

2

3

High-throughput

0.606

High

154468

ICAM3
Intercellular adhesion molecule 3

2

2

High-throughput

0.606

High

154471

CXA8
Gap junction alpha-8 protein

2

1

High-throughput

0.606

High

154501

GOLM1
Golgi membrane protein 1

2

1

High-throughput

0.606

High

154473

CXAR
Coxsackievirus and adenovirus receptor

1

0

Small-scale

0.586

High

154493

TSPO2
Translocator protein 2

2

0

High-throughput

0.580

High

154500

SYT2
Synaptotagmin-2

2

0

High-throughput

0.580

High

154506

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

154483

AQP6
Aquaporin-6

2

4

High-throughput

0.553

High

154489

AR13B
ADP-ribosylation factor-like protein 13B

2

2

High-throughput

0.553

High

154490

TM52B
Transmembrane protein 52B

2

1

High-throughput

0.553

High

154491

F209A
Protein FAM209A

2

2

High-throughput

0.553

High

154494

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

2

High-throughput

0.553

High

154495

CLC14
C-type lectin domain family 14 member A

2

2

High-throughput

0.553

High

154452

IGSF3
Immunoglobulin superfamily member 3

1

1

Small-scale

0.553

High

154478

ZO1
Tight junction protein 1

1

20

Small-scale

0.501

High

154448

YKT6
Synaptobrevin homolog YKT6

1

1

Small-scale

0.479

High

154451

CTND1
Catenin delta-1

1

1

Small-scale

0.479

High

154454

EGFR
Epidermal growth factor receptor

1

2

Small-scale

0.479

High

154457

ITB1
Integrin beta-1

1

1

Small-scale

0.479

High

154458

YES
Tyrosine-protein kinase Yes

1

2

Small-scale

0.479

High

154461

PLAK
Junction plakoglobin

1

1

Small-scale

0.479

High

154462

ITB5
Integrin beta-5

1

1

Small-scale

0.479

High

154463

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

1

Small-scale

0.479

High

154465

EPHA2
Ephrin type-A receptor 2

1

1

Small-scale

0.479

High

154466

EPHB2
Ephrin type-B receptor 2

1

2

Small-scale

0.479

High

154467

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

Small-scale

0.479

High

154470

NOTC1
Neurogenic locus notch homolog protein 1

1

1

Small-scale

0.479

High

154475

DSC2
Desmocollin-2

1

1

Small-scale

0.479

High

154477

NOTC2
Neurogenic locus notch homolog protein 2

1

2

Small-scale

0.479

High

154482

DLG1
Disks large homolog 1

1

1

Small-scale

0.479

High

154484

DSG2
Desmoglein-2

1

1

Small-scale

0.479

High

123940

SNP23
Synaptosomal-associated protein 23

1

0

Small-scale

0.458

High

154446

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

0

Small-scale

0.458

High

154450

E41L2
Band 4.1-like protein 2

1

0

Small-scale

0.458

High

154453

CBPD
Carboxypeptidase D

1

0

Small-scale

0.458

High

154456

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

Small-scale

0.458

High

154459

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.458

High

154460

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

Small-scale

0.458

High

154464

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

Small-scale

0.458

High

154472

RAB7A
Ras-related protein Rab-7a

1

0

Small-scale

0.458

High

154474

LAT1
Large neutral amino acids transporter small subunit 1

1

0

Small-scale

0.458

High

154476

AKA12
A-kinase anchor protein 12

1

0

Small-scale

0.458

High

154479

S20A2
Sodium-dependent phosphate transporter 2

1

0

Small-scale

0.458

High

154480

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

Small-scale

0.458

High

154487

AAAT
Neutral amino acid transporter B(0)

1

0

Small-scale

0.458

High

154488

OCLN
Occludin

1

0

Small-scale

0.458

High

154496

LIPB1
Liprin-beta-1

1

0

Small-scale

0.458

High

154497

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

Small-scale

0.458

High

154503

FERM2
Fermitin family homolog 2

1

0

Small-scale

0.458

High

154504

KIRR1
Kin of IRRE-like protein 1

1

0

Small-scale

0.458

High

154505

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

1

0

Small-scale

0.458

High

154507

ERBIN
Erbin

1

0

Small-scale

0.458

High

154508

EHD1
EH domain-containing protein 1

1

0

Small-scale

0.458

High

154509

ADDG
Gamma-adducin

1

0

Small-scale

0.458

High

154510

CEIP2
Cell surface hyaluronidase CEMIP2

1

0

Small-scale

0.458

High

154511

LCAP
Leucyl-cystinyl aminopeptidase

1

0

Small-scale

0.458

High

154512

S39AA
Zinc transporter ZIP10

1

0

Small-scale

0.458

High

154513

BAIP2
BAR/IMD domain-containing adapter protein 2

1

0

Small-scale

0.458

High

154515

S4A7
Sodium bicarbonate cotransporter 3

1

0

Small-scale

0.458

High

154481

AP1B1
AP-1 complex subunit beta-1

1

1

Small-scale

0.437

High

154486

TRIPB
Thyroid receptor-interacting protein 11

1

1

Small-scale

0.437

High

154499

PHAR4
Phosphatase and actin regulator 4

1

2

Small-scale

0.437

High

154502

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

154492

MF14B
Hippocampus abundant transcript-like protein 1

2

0

High-throughput

0.316

High

154498

TRI59
Tripartite motif-containing protein 59

2

0

High-throughput

0.316

High

154455

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.251

Low

154447

PGRC2
Membrane-associated progesterone receptor component 2

1

0

Small-scale

0.249

Low

154485

GOGB1
Golgin subfamily B member 1

1

0

Small-scale

0.249

Low

154514

MAN1
Inner nuclear membrane protein Man1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025