HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: CACO1 (Q9P1Z2)
Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3)
Gene: CALCOCO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.685

Property	Details
Experiments	25416956, 16189514, 33961781
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 642 Hs			1 691
+	Hs
		1127257 TGO1_HUMAN (195-642): 2.07e-29: 127: 15.45		TAXB1_HUMAN (15-680): 1.63e-57: 210: 24.60
+	Hs
		1201957 MRCKB_HUMAN (258-642): 1.73e-21: 102: 12.78		TAXB1_HUMAN (15-680): 1.63e-57: 210: 24.60
+	Hs
		1127294 TGO1_HUMAN (195-642): 2.07e-29: 127: 15.45		MIA2_HUMAN (123-650): 1.75e-28: 124: 13.29
+	Rn
		222476 MRCKA_RAT (181-627): 1.66e-21: 102: 10.82		MRCKB_RAT (78-654): 1.52e-32: 137: 14.79
+	Rn
		1186812 MRCKB_RAT (266-642): 2.4e-19: 95.2: 10.61		MRCKB_RAT (78-654): 1.52e-32: 137: 14.79
+	Hs
		725002 UACA_HUMAN (191-641): 1.51e-30: 130: 13.88		MYH9_HUMAN (201-686): 9.8e-21: 100: 12.25
+	Hs
		1137917 MRCKB_HUMAN (258-642): 1.73e-21: 102: 12.78		MRCKA_HUMAN (100-672): 4.1e-26: 117: 14.89
+	Hs
		1137871 MRCKA_HUMAN (140-627): 3.84e-19: 94.5: 11.42		MRCKA_HUMAN (100-672): 4.1e-26: 117: 14.89
+	Hs
		1127261 TGO1_HUMAN (195-642): 2.07e-29: 127: 15.45		CTGE4_HUMAN (194-658): 3.64e-13: 74.9: 14.14
+	Hs
		724687 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH10_HUMAN (19-516): 9.32e-23: 106: 11.80
+	Hs
		725097 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		MYH10_HUMAN (19-516): 9.32e-23: 106: 11.80
+	Hs
		724686 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH9_HUMAN (201-686): 9.8e-21: 100: 12.25
+	Hs
		725095 MYH10_HUMAN (171-636): 1.34e-15: 83.3: 12.84		MYH10_HUMAN (19-516): 9.32e-23: 106: 11.80
+	Rn
		222472 MRCKA_RAT (181-627): 1.66e-21: 102: 10.82		MRCKA_RAT (308-676): 3.17e-15: 82: 10.40
+	Hs
		724805 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		CACO2_HUMAN (260-475): 1.2e-10: 66: 16.67
+	Mm
		93570 DESP_MOUSE (190-642): 1.18e-15: 83.5: 15.27		MYH9_MOUSE (316-691): 7.15e-12: 71.2: 10.08