Protein: NRG1
Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]

Gene: NRG1
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q02297

Gene Ontology (top 5):
GO:0003222 - ventricular trabecula myocardium morphogenesis
GO:0003712 - transcription coregulator activity
GO:0005102 - signaling receptor binding
GO:0005125 - cytokine activity
GO:0005178 - integrin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

641575

ERBB3
Receptor tyrosine-protein kinase erbB-3

10

20

Small-scale

0.978

High

363153

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.884

High

321760

AGRL1
Adhesion G protein-coupled receptor L1

3

1

High-throughput

0.861

High

1036208

TMTC4
Protein O-mannosyl-transferase TMTC4

3

2

High-throughput

0.861

High

1036218

ZDH17
Palmitoyltransferase ZDHHC17

3

8

High-throughput

0.861

High

1036205

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

20

Small-scale

0.792

High

1036247

CNTP3
Contactin-associated protein-like 3

2

7

High-throughput

0.789

High

455966

ASGR2
Asialoglycoprotein receptor 2

2

7

High-throughput

0.783

High

641461

CD72
B-cell differentiation antigen CD72

2

8

High-throughput

0.783

High

1036235

S67A1
Solute carrier family 67 member A1

2

0

High-throughput

0.748

High

1036222

LARG2
Xylosyl- and glucuronyltransferase LARGE2

3

0

High-throughput

0.720

High

908961

NEK4
Serine/threonine-protein kinase Nek4

2

2

High-throughput

0.705

High

410779

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.692

High

1036246

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

4

High-throughput

0.691

High

775757

ATP7B
Copper-transporting ATPase 2

3

1

High-throughput

0.667

High

1036203

SRBP2
Sterol regulatory element-binding protein 2

3

2

High-throughput

0.667

High

1036265

POMT1
Protein O-mannosyl-transferase 1

3

1

High-throughput

0.667

High

239488

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

3

0

High-throughput

0.638

High

1036207

TM63B
Mechanosensitive cation channel TMEM63B

3

0

High-throughput

0.638

High

1036215

LSR
Lipolysis-stimulated lipoprotein receptor

3

0

High-throughput

0.638

High

1036223

CISD2
CDGSH iron-sulfur domain-containing protein 2

3

0

High-throughput

0.638

High

1036230

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

3

0

High-throughput

0.638

High

1036248

TM39B
Transmembrane protein 39B

3

0

High-throughput

0.638

High

1036255

INT7
Integrator complex subunit 7

3

0

High-throughput

0.638

High

1036211

TMTC3
Protein O-mannosyl-transferase TMTC3

1

2

High-throughput

0.618

High

409571

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

2

5

High-throughput

0.611

High

1036263

MAN1
Inner nuclear membrane protein Man1

2

1

High-throughput

0.611

High

322720

RHBT3
Rho-related BTB domain-containing protein 3

3

17

High-throughput

0.609

High

593585

GDC
Solute carrier family 25 member 16

3

2

High-throughput

0.609

High

1036228

GLT11
Polypeptide N-acetylgalactosaminyltransferase 11

3

2

High-throughput

0.609

High

1036244

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

3

2

High-throughput

0.609

High

1036245

SFXN3
Sideroflexin-3

3

1

High-throughput

0.609

High

1036256

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

3

2

High-throughput

0.609

High

1036209

TM164
Transmembrane protein 164

2

0

High-throughput

0.585

High

1036220

K2013
Uncharacterized protein KIAA2013

2

0

High-throughput

0.585

High

1036232

GLMN
Glomulin

2

0

High-throughput

0.585

High

1036239

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

2

0

High-throughput

0.585

High

1036243

TM2D3
TM2 domain-containing protein 3

2

0

High-throughput

0.585

High

949236

MYPR
Myelin proteolipid protein

2

0

High-throughput

0.580

High

1036214

LAP4B
Lysosomal-associated transmembrane protein 4B

2

0

High-throughput

0.580

High

1036234

TMM54
Transmembrane protein 54

2

0

High-throughput

0.580

High

1036238

M4A4A
Membrane-spanning 4-domains subfamily A member 4A

2

0

High-throughput

0.580

High

922246

LIMK1
LIM domain kinase 1

1

8

Small-scale

0.573

High

1036227

B3GL2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

2

2

High-throughput

0.558

High

211916

SPIT1
Kunitz-type protease inhibitor 1

1

3

High-throughput

0.536

High

316493

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

2

High-throughput

0.536

High

520817

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.536

High

551992

ADT1
ADP/ATP translocase 1

1

1

High-throughput

0.536

High

788526

SCNNA
Epithelial sodium channel subunit alpha

1

1

High-throughput

0.536

High

907896

PLXA3
Plexin-A3

1

3

High-throughput

0.536

High

1036241

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1036262

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

2

High-throughput

0.536

High

1036264

ORNT1
Mitochondrial ornithine transporter 1

1

3

High-throughput

0.536

High

1036233

H2B1H
Histone H2B type 1-H

1

13

High-throughput

0.515

High

61101

T131L
Transmembrane protein 131-like

1

0

High-throughput

0.513

High

166902

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.513

High

219807

CHSTA
Carbohydrate sulfotransferase 10

1

0

High-throughput

0.513

High

963557

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.513

High

1036206

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

0

High-throughput

0.513

High

1036221

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.513

High

1036249

SEM6B
Semaphorin-6B

1

0

High-throughput

0.513

High

1036260

B4GT7
Beta-1,4-galactosyltransferase 7

1

0

High-throughput

0.513

High

686805

S10A4
Protein S100-A4

1

3

Small-scale

0.501

High

1036204

TBB3
Tubulin beta-3 chain

1

5

High-throughput

0.489

High

1036213

GALT5
Polypeptide N-acetylgalactosaminyltransferase 5

1

2

High-throughput

0.489

High

1036219

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

2

High-throughput

0.489

High

1036240

SFXN2
Sideroflexin-2

1

1

High-throughput

0.489

High

373890

RASN
GTPase NRas

1

13

High-throughput

0.479

High

990117

1433Z
14-3-3 protein zeta/delta

1

9

High-throughput

0.479

High

1036216

GOLI
E3 ubiquitin-protein ligase RNF130

1

7

High-throughput

0.479

High

1036237

MYO19
Unconventional myosin-XIX

1

7

High-throughput

0.479

High

1036242

ABCA3
Phospholipid-transporting ATPase ABCA3

1

2

High-throughput

0.479

High

1036258

MTCH1
Mitochondrial carrier homolog 1

1

3

High-throughput

0.479

High

60714

F234B
Protein FAM234B

1

0

High-throughput

0.458

High

178624

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.458

High

230782

EXTL3
Exostosin-like 3

1

0

High-throughput

0.458

High

483901

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.458

High

687100

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

0

High-throughput

0.458

High

1036210

TM205
Transmembrane protein 205

1

0

High-throughput

0.458

High

1036226

NETO2
Neuropilin and tolloid-like protein 2

1

0

High-throughput

0.458

High

1036250

PIGU
GPI-anchor transamidase component PIGU

1

0

High-throughput

0.458

High

1036252

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.458

High

1036257

CALY
Neuron-specific vesicular protein calcyon

1

0

Small-scale

0.458

High

1036259

TM181
Transmembrane protein 181

1

0

High-throughput

0.458

High

380535

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

5

High-throughput

0.445

High

105783

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

1036229

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

1036231

RDH11
Retinol dehydrogenase 11

1

1

High-throughput

0.437

High

1036236

C1GLC
C1GALT1-specific chaperone 1

1

1

High-throughput

0.437

High

1036212

PGAP1
GPI inositol-deacylase

3

0

High-throughput

0.347

High

1036217

DAAF5
Dynein axonemal assembly factor 5

3

0

High-throughput

0.347

High

1036261

DSE
Dermatan-sulfate epimerase

3

0

High-throughput

0.347

High

1036225

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

2

0

High-throughput

0.318

High

1036251

OPA3
Optic atrophy 3 protein

2

0

High-throughput

0.318

High

1036224

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.316

High

1036253

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.279

Low

168981

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.249

Low

184982

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.249

Low

328238

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.249

Low

1036254

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025