Interactor 1: TNF11 (O14788)
Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
Gene: TNFSF11

Interactor 2: TNR11 (Q9Y6Q6)
Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265)
Gene: TNFRSF11A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.812

The method score is based on:

Property Details
Experiments 23333834, 22664871
Identification Methods enzyme linked immunosorbent assay, surface plasmon resonance, pull down
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains RANK_CRD_2~TNF, TNF~TNFR_c6
Common GO terms GO:0001503 - ossification
GO:0002548 - monocyte chemotaxis
GO:0005886 - plasma membrane
GO:0030316 - osteoclast differentiation
GO:0033209 - tumor necrosis factor-mediated signaling pathway
and 7 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 317
Hs

1 616
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024